Initial Statement of Beneficial Ownership (Form 3)

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Frazier Life Sciences Public Fund, L.P. 2. Date of Event Requiring Statement (Month/Day/Year) 11/25/2025 3. Issuer Name and Ticker or Trading Symbol Adverum Biotechnologies, Inc. [ADVM] (Last) (First) (Middle) C/O FRAZIER LIFE SCIENCES MANAGEMENT, L., 1001 PAGE MILL RD, BUILDING 4, SUITE B 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) 5. If Amendment, Date Original Filed (Month/Day/Year) (Street) PALO ALTO, CA 94304 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 4,288,949 D(1)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Frazier Life Sciences Public Fund, L.P. C/O FRAZIER LIFE SCIENCES MANAGEMENT, L. 1001 PAGE MILL RD, BUILDING 4, SUITE B PALO ALTO, CA 94304		X
FHMLSP, L.P. FRAZIER LIFE SCIENCES MANAGEMENT, L.P. 1001 PAGE MILL RD, BUILDING 4, SUITE B PALO ALTO, CA 94304		X
FHMLSP, L.L.C. FRAZIER LIFE SCIENCES MANAGEMENT, L.P 1001 PAGE MILL RD, BUILDING 4, SUITE B PALO ALTO, CA 94304		X

Signatures

/s/ Steve R. Bailey, CFO of FHMLSP, L.L.C., GP of FHMLSP, L.P., GP of Frazier Life Sciences Public Fund, L.P.		12/05/2025
**Signature of Reporting Person		Date
/s/ Steve R. Bailey, CFO of FHMLSP, L.L.C., GP of FHMLSP, L.P.		12/05/2025
**Signature of Reporting Person		Date
/s/ Steve R. Bailey, CFO of FHMLSP, L.L.C.		12/05/2025
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The shares are held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P.

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