Material Event (Form 8-K)

On August 11, 2025, the Company entered into an Underwriting Agreement (the "Underwriting Agreement"), between the Company and the underwriters named therein, for the issuance and sale by the Company of $850,000,000 aggregate principal amount of its 4.150% Senior Notes due 2028 (the "2028 Notes") and $1,000,000,000 aggregate principal amount of its 5.000% Senior Notes due 2035 (the "2035 Notes" and, together with the 2028 Notes, the "Notes"). The Notes were issued pursuant to an indenture, dated January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (the "Base Indenture"), as supplemented by the seventh supplemental indenture (the "Seventh Supplemental Indenture" and, together with the Base Indenture, the "Indenture") dated as of August 18, 2025, between Zoetis Inc. and Deutsche Bank Trust Company Americas, as trustee. The offering of the Notes was registered on a Registration Statement on Form S-3(File No. 333-289241).

The above description of the Underwriting Agreement, the Base Indenture and the Notes is qualified in its entirety by reference to the Underwriting Agreement, the Indenture, the Seventh Supplemental Indenture and the forms of the Notes filed as exhibits hereto, which exhibits are incorporated by reference herein.