Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * SR ONE CAPITAL MANAGEMENT, LLC 2. Issuer Name and Ticker or Trading Symbol Odyssey Therapeutics, Inc. [ODTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 929 MAIN STREET, SUITE 200 3. Date of Earliest Transaction (Month/Day/Year) 05/11/2026 (Street) REDWOOD CITY, CA 94063 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 05/11/2026 C 474,048 A (1) 474,048 I See Note 2(2) Common Stock 05/11/2026 C 139,366 A (3) 613,414 I See Note 2(2) Common Stock 05/11/2026 C 59,692 A (4) 673,106 I See Note 2(2) Common Stock 05/11/2026 C 61,762 A (5) 734,868 I See Note 2(2) Common Stock 05/11/2026 C 683,817 A (6) 1,418,685 I See Note 2(2) Common Stock 05/11/2026 X 191,541 A (7) 1,610,226 I See Note 2(2) Common Stock 05/11/2026 S(7) 1,065(8) D $18 1,609,161 I See Note 2(2) Common Stock 05/11/2026 P 222,222 A $18 1,831,383 I See Note 2(2) Common Stock 05/11/2026 C 118,512 A (1) 118,512 I See Note 9(9) Common Stock 05/11/2026 C 255,823 A (4) 374,335 I See Note 9(9) Common Stock 05/11/2026 C 204,658 A (4) 204,658 I See Note 10(10) Common Stock 05/11/2026 C 20,582 A (5) 225,240 I See Note 10(10) Common Stock 05/11/2026 C 166,168 A (6) 391,408 I See Note 10(10) Common Stock 05/11/2026 X 49,850 A (7) 441,258 I See Note 10(10) Common Stock 05/11/2026 S(7) 277(11) D $18 440,981 I See Note 10(10) Common Stock 05/11/2026 P 133,333 A $18 574,314 I See Note 10(10) Common Stock 05/11/2026 C 463,106 A (5) 463,106 I See Note 12(12) Common Stock 05/11/2026 C 273,527 A (6) 736,633 I See Note 12(12) Common Stock 05/11/2026 X 78,656 A (7) 815,289 I See Note 12(12) Common Stock 05/11/2026 S(7) 438(13) D $18 814,851 I See Note 12(12) Common Stock 05/11/2026 P 200,000 A $18 1,014,851 I See Note 12(12)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Convertible Preferred Stock	(1)	05/11/2026		C			4,606,320	(1)	(1)	Common Stock	474,048	(1)	0	I	See Note 2(2)
Series A-2 Convertible Preferred Stock	(3)	05/11/2026		C			1,299,842	(3)	(3)	Common Stock	139,366	(3)	0	I	See Note 2(2)
Series B Convertible Preferred Stock	(4)	05/11/2026		C			544,162	(4)	(4)	Common Stock	59,692	(4)	0	I	See Note 2(2)
Series C Convertible Preferred Stock	(5)	05/11/2026		C			600,142	(5)	(5)	Common Stock	61,762	(5)	0	I	See Note 2(2)
Series D Convertible Preferred Stock	(6)	05/11/2026		C			6,644,650	(6)	(6)	Common Stock	683,817	(6)	0	I	See Note 2(2)
Series D Warrants (Right to Buy)	$0.1	05/11/2026		X			1,861,211	(7)	(7)	Common Stock	191,541	(7)	0	I	See Note 2(2)
Series A Convertible Preferred Stock	(1)	05/11/2026		C			1,151,580	(1)	(1)	Common Stock	118,512	(1)	0	I	See Note 9(9)
Series B Convertible Preferred Stock	(4)	05/11/2026		C			2,374,981	(4)	(4)	Common Stock	255,823	(4)	0	I	See Note 9(9)
Series B Convertible Preferred Stock	(4)	05/11/2026		C			1,899,984	(4)	(4)	Common Stock	204,658	(4)	0	I	See Note 10(10)
Series C Convertible Preferred Stock	(5)	05/11/2026		C			200,000	(5)	(5)	Common Stock	20,582	(5)	0	I	See Note 10(10)
Series D Convertible Preferred Stock	(6)	05/11/2026		C			1,614,650	(6)	(6)	Common Stock	166,168	(6)	0	I	See Note 10(10)
Series D Warrants (Right to Buy)	$0.1	05/11/2026		X			484,395	(7)	(7)	Common Stock	49,850	(7)	0	I	See Note 10(10)
Series C Convertible Preferred Stock	(5)	05/11/2026		C			4,500,000	(5)	(5)	Common Stock	463,106	(5)	0	I	See Note 12(12)
Series D Convertible Preferred Stock	(6)	05/11/2026		C			2,657,860	(6)	(6)	Common Stock	273,527	(6)	0	I	See Note 12(12)
Series D Warrants (Right to Buy)	$0.1	05/11/2026		X			764,312	(7)	(7)	Common Stock	78,656	$ 0	0	I	See Note 12(12)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SR ONE CAPITAL MANAGEMENT, LLC 929 MAIN STREET SUITE 200 REDWOOD CITY, CA 94063		X
George Simeon 929 MAIN STREET SUITE 200 REDWOOD CITY, CA 94063		X

Signatures

/s/ Sasha Keough, attorney-in-fact for SR One Capital Management, LLC		05/11/2026
**Signature of Reporting Person		Date
/s/ Sasha Keough, attorney-in-fact for Simeon George		05/11/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The Series A Preferred Stock automatically converted into Common Stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-9.7170 basis for no additional consideration.
(2)	The securities are directly held by SR One Capital Fund I Aggregator, LP ("SR One Fund I Aggregator"). SR One Capital Partners I, LP ("SR One Partners I") is the sole general partner of SR One Fund I Aggregator, and SR One Capital Management, LLC ("SR One Capital Management") is the sole general partner of SR One Partners I. Simeon George, M.D. is the managing member of SR One Capital Management. Each of SR One Capital Partners I, SR One Capital Management and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(3)	The Series A-2 Preferred Stock automatically converted into Common Stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-9.3268 basis for no additional consideration.
(4)	The Series B Preferred Stock automatically converted into Common Stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-9.2837 basis for no additional consideration.
(5)	The Series C Preferred Stock automatically converted into Common Stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-9.7170 basis for no additional consideration.
(6)	The Series D Preferred Stock automatically converted into Common Stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-9.7170 basis for no additional consideration.
(7)	The warrants to purchase shares of common stock were automatically exercised into shares of Common Stock by their terms immediately prior to the closing of the Issuer's initial public offering on a net exercise basis.
(8)	Pursuant to the terms of the warrants, the Issuer withheld 1,065 warrant shares to pay the exercise price in connection with the net exercise.
(9)	The securities are directly held by SR One Co-Invest IV, LLC ("SR One Co-Invest IV"). SR One Co-Invest IV Manager, LLC ("SR One Co-Invest Manager") is the managing member of SR One-Co-Invest IV, and SR One Capital Management is the managing member of SR One Co-Invest Manager. Simeon George, M.D. is the managing member of SR One Capital Management. Each of SR One Co-Invest Manager, SR One Capital Management and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(10)	The securities are directly held by SR One Co-Invest IV-A, LLC ("SR One Co-Invest IV-A"). SR One Co-Invest IV Manager is the managing member of SR One-Co-Invest IV-A, and SR One Capital Management is the managing member of SR One Co-Invest Manager. Simeon George, M.D. is the managing member of SR One Capital Management. Each of SR One Co-Invest Manager, SR One Capital Management and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(11)	Pursuant to the terms of the warrants, the Issuer withheld 277 warrant shares to pay the exercise price in connection with the net exercise.
(12)	The reported securities are held directly by AMZL, LP ("AMZL"). SR One Capital SMA Partners, LP ("SR One SMA Partners") is the general partner of AMZL, and SR One Capital Management is the general partner of SR One SMA Partners. Simeon George, M.D. is the managing member of SR One Capital Management. Each of SR One SMA Partners, SR One Capital Management and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.
(13)	Pursuant to the terms of the warrants, the Issuer withheld 438 warrant shares to pay the exercise price in connection with the net exercise.

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