04/04/2025 | Press release | Distributed by Public on 04/04/2025 14:17
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Filed by the Registrant ☒
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Filed by a Party other than the Registrant ☐
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☐
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Preliminary Proxy Statement
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☐
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Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
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☒
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Definitive Proxy Statement
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Definitive Additional Materials
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Soliciting Material Pursuant to ☐ 240.14a-11(c) or ☐ 240.14a-2
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☒
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No fee required.
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Fee paid previously with preliminary materials.
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Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.
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to elect three Class II directors to serve until our 2028 annual meeting of stockholders and until their successors are duly elected and qualified;
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to ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025; and
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to transact such other business as may properly come before the Annual Meeting or any adjournments or postponements thereof.
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By order of the Board of Directors,
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/s/ Jeffrey M. Dayno
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Dr. Jeffrey M. Dayno, President, Chief Executive
Officer and Director
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Plymouth Meeting, Pennsylvania
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April 4, 2025
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PAGE
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QUESTIONS AND ANSWERS ABOUT THE PROXY MATERIALS AND OUR ANNUAL MEETING
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1
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BOARD OF DIRECTORS AND CORPORATE GOVERNANCE
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7
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Considerations in Evaluating Director Nominees
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8
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Nominees for Director
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8
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Continuing Directors
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10
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Board Leadership Structure
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12
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Board Meetings and Committees
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13
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Compensation Committee Interlocks and Inside Participation
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14
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Stockholder Recommendations and Nominations to the Board of Directors
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14
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Anti-Hedging Policy
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15
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Communications with the Board of Directors
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15
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Corporate Governance Overview
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15
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Corporate Governance Guidelines and Code of Ethics and Conduct Policy
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Risk Management
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Succession Planning
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PROPOSAL NO. 1 ELECTION OF DIRECTORS
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18
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Nominees
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18
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Vote Required
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PROPOSAL NO. 2 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
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Fees Paid to the Independent Registered Public Accounting Firm
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Auditor Independence
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Pre-Approval Policies and Procedures
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Vote Required
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REPORT OF THE AUDIT COMMITTEE
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EXECUTIVE OFFICERS
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COMPENSATION COMMITTEE REPORT
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24
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COMPENSATION DISCUSSION AND ANALYSIS
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25
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General
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25
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Executive Summary
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25
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Elements of Compensation
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29
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Executive Compensation Tables
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34
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Director Compensation
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48
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Equity Compensation Plan Information Table
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53
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PAGE
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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
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54
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RELATED PERSON TRANSACTIONS
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56
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Policies and Procedures for Related Person Transactions
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57
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OTHER MATTERS
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58
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Delinquent Section 16(a) Reports
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58
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Fiscal Year 2024 Annual Report and SEC Filings
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58
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Special Note Regarding Forward-Looking Statements
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58
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PROPOSAL
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HARMONY BOARD
OF DIRECTORS
VOTING
RECOMMENDATION
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PAGE
REFERENCE
(FOR MORE
DETAIL)
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PROPOSAL NO. 1
The election of three Class II directors to serve until our 2028 annual meeting of stockholders and until their successors are duly elected and qualified.
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FOR each nominee
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18
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PROPOSAL NO. 2
Ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.
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FOR
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PROPOSAL
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VOTE NEEDED FOR APPROVAL AND EFFECT OF ABSTENTIONS AND BROKER NON-VOTES
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PROPOSAL NO. 1
The election of three Class II directors to serve until our 2028 annual meeting of stockholders and until their successors are duly elected and qualified.
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Our amended and restated Bylaws ("Bylaws") state that to be elected, a nominee must receive a plurality of the votes of the shares present or represented by proxy and entitled to vote on the election of directors. "Plurality" means that the three individuals who receive the largest number of votes cast "FOR" by the stockholders entitled to vote are elected as directors. Abstentions will have no effect on the outcome of this proposal. Broker non-votes will have no effect on the outcome of this proposal.
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PROPOSAL NO. 2
Ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.
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For this proposal to be approved, it must receive more votes "FOR" than "AGAINST" the proposal. Abstentions will have no effect on the outcome of this proposal. We do not anticipate broker non-votes on this proposal.
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by Internet before the annual meeting at www.proxyvote.com, 24 hours a day, seven days a week, until 11:59 p.m. Eastern Time on May 14, 2025 (have your Notice or proxy card in hand when you visit the website);
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by toll-free telephone at 1-800-690-6903 until 11:59 p.m. Eastern Time on May 14, 2025 (have your Notice or proxy card in hand when you call);
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by completing and mailing your proxy card (if you received printed proxy materials) to be received prior to the Annual Meeting; or
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by attending the virtual meeting by visiting www.virtualshareholdermeeting.com/HRMY2025, where you may vote and submit questions during the Annual Meeting. Please have your Notice or proxy card in hand when you visit the website. For more information on how to attend and vote at the Annual Meeting, please see the section titled "Questions and Answers About the Proxy Materials and Our Annual Meeting: What do I need to do to attend the Annual Meeting virtually?" on page 3.
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entering a new vote by Internet or by telephone;
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completing and returning a later-dated proxy card;
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notifying the General Counsel of Harmony Biosciences Holdings, Inc., in writing, at Harmony Biosciences Holdings, Inc., 630 W. Germantown Pike, Suite 215, Plymouth Meeting, Pennsylvania 19462; or
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virtually attending and voting at the Annual Meeting (although attendance at the Annual Meeting will not, by itself, revoke a proxy).
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not earlier than January 15, 2026; and
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not later than February 14, 2026.
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the 90th day prior to our 2026 annual meeting of stockholders; or, if later
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the 10th day following the day on which public announcement of the date of the 2026 annual meeting of stockholders is first made.
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CLASS
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AGE
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POSITION
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DIRECTOR
SINCE
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CURRENT
TERM
EXPIRES
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EXPIRATION
OF TERM
FOR WHICH
NOMINATED
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INDEPENDENT
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AUDIT
COMMITTEE
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COMP.
COMMITTEE
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NOMINATING
AND
CORPORATE
GOVERNANCE
COMMITTEE
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Directors with Terms expiring at the Annual Meeting/Nominees
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Juan A. Sabater
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II
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60
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Director
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2017
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2025
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2028
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X
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Gary Sender
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II
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63
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Director
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2020
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2025
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2028
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X
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Linda Szyper
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II
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59
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Director
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2021
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2025
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2028
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X
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Continuing Directors
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Jeffrey S. Aronin
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Director, Chairman
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2017
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2027
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-
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R. Mark Graf
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60
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Director
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2020
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2027
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-
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X
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Jeffrey M. Dayno
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67
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President and Chief Executive Officer, Director
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2023
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2027
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-
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Antonio Gracias
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III
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54
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Director
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2017
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2026
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-
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X
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Andreas Wicki, Ph.D.
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III
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66
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Director
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2017
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2026
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-
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X
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Peter Anastasiou
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III
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54
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Director
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2023
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2026
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-
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Ron Philip
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III
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51
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Director
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2025
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2026
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-
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X
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Legend:
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Chair
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Member
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Audit committee financial expert
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*
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Effective April 7, 2025
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the candidate's experience in corporate management, such as serving as an officer or former officer of a publicly held company;
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the candidate's experience as a board member of another publicly held company;
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the candidate's professional and academic experience relevant to the Company's industry;
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the strength of the candidate's leadership skills;
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the candidate's experience in finance and accounting and / or executive compensation practices;
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whether the candidate has the time required for preparation, participation and attendance at Board meetings and committee meetings, if applicable; and
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the candidate's geographic background, gender, age and ethnicity.
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JUAN A. SABATER
President of Valor Management LLC
Director since 2017
Age 60
Committees: Nominating and Corporate Governance Committee (Chair)
Juan A. Sabaterhas served on our board of directors since 2017. Mr. Sabater has served in various roles at Valor since 2010, most recently as Partner and Co-President. Prior to joining Valor, Mr. Sabater was a Managing Director of Goldman Sachs & Co. in their Investment Banking Division, from 1998 to 2006. He also currently serves on the board of several private companies and organizations including The Frick Collection and Lenox Hill Neighborhood House in New York City. Mr. Sabater currently serves as the Co-Chairman of Augeo Affinity Marketing, Inc. and on the Financial Oversight & Management Board for Puerto Rico. He previously served on the Board of Visitors of the United States Military Academy. He received an A.B. in history from Princeton University and a J.D. from Stanford Law School. Mr. Sabater was also a former officer in the U.S. Army Reserve. We believe that Mr. Sabater is qualified to serve on our board of directors due to his expansive skillset including his management experience with a nationally recognized private equity firm and an investment banking company, along with his demonstrated business acumen.
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GARY SENDER
Former Chief Financial Officer of Nabriva Therapeutics
Director since 2020
Age 63
Committees: Audit Committee (Chair and Audit Committee Financial Expert), Compensation Committee
Gary Sender has served as a member of our board of directors since August 2020. Mr. Sender served as Chief Financial Officer of Nabriva Therapeutics plc, or Nabriva, a publicly traded biopharmaceutical company engaged in the commercialization and development of innovative anti-infective agents to treat serious infections, from May 2016 to March 2021. Prior to joining Nabriva, Mr. Sender served as Chief Financial Officer and Executive Vice President at Synergy Pharmaceuticals Inc., or Synergy, a publicly traded biopharmaceutical company, from November 2015 to April 2016. Prior to joining Synergy, from August 2009 to June 2015, Mr. Sender served as Senior Vice President, Finance at Shire plc, or Shire, a biopharmaceutical company since acquired by Takeda Pharmaceutical Company Limited, supporting its Specialty Pharmaceuticals business and subsequently its Global Commercial businesses. Prior to joining Shire, Mr. Sender served as founding Chief Financial Officer of Tengion, Inc., a regenerative medicine company, from August 2004 to July 2009. Mr. Sender also spent over 15 years in several leadership roles within Merck & Co., Inc., a publicly traded pharmaceutical company. Mr. Sender currently serves on the board of Schrödinger, Inc. and is the Chairman of their Audit and Compensation Committees. Mr. Sender also currently serves on the board of iBio, a publicly traded life sciences company, as Chairman of their Compensation Committee and Chairman of their Audit Committee. Mr. Sender received a B.S. in Finance from Boston University and an M.B.A. from Carnegie-Mellon University. We believe that Mr. Sender is qualified to serve on our board of directors because of his extensive finance and life sciences industry experience, as well as his demonstrated business acumen.
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LINDA SZYPER
Former Chief Operating Officer of McCann Health
Director since 2021
Age 59
Committees: Nominating and Corporate Governance Committee
Linda Szyper has served on our board of directors since November 2021. Ms. Szyper currently serves as an independent life sciences consultant. Previously, she served as the Chief Operating Officer of McCann Health, a global healthcare communications company, from January 2018 to October 2021. Prior to joining McCann Health, Ms. Szyper served as the Chief Commercial Officer of Circassia, a publicly traded biotechnology and medical device company headquartered in the United Kingdom, from October 2014 to March 2017, and as the Chief Development Officer of Publicis Healthcare Communications Group, a healthcare communications network, from January 2008 to October 2014. Ms. Syzper served on the board of Neos Therapeutics, a public pharmaceutical company, from March 2018 to March 2021. Ms. Szyper was selected to the Board because of her extensive experience in pharmaceutical marketing, medical communications, consumer health and payer and patient engagement, and we believe she will bring valuable experience and insight to the Board.
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JEFFREY S. ARONIN
Chairman and Chief Executive Officer of Paragon Biosciences and Founder of Harmony
Director since 2017
Age 57
Committees: None
Jeffrey S. Aroninfounded Harmony and has served on our board of directors since October 2017, and as Non-Executive Chairman since April 2023. Mr. Aronin previously served as Executive Chairman from January 2023 to April 2023, and as Non-executive Chairman from October 2017 to January 2023. In June 2017, Mr. Aronin founded Paragon Biosciences which he leads as Chairman and Chief Executive Officer. Paragon Biosciences is a life science innovator that invests in, builds, and advises a portfolio of bioscience companies. In addition to serving on our board, Mr. Aronin serves on the boards of other Paragon privately-held portfolio companies, including Evozyne, Inc., which uses generative AI to engineer novel proteins, Castle Creek Biosciences, Inc., which is dedicated to rare genetic dermatology, Emalex Biosciences Inc., which is dedicated to treating neurological conditions, and CIRC Biosciences, Inc., a regenerative medicine biotechnology company. From January 2011 to May 2017, Mr. Aronin was the Chairman and Chief Executive Officer of Marathon Pharmaceuticals, LLC, a private research-based biopharmaceutical company that developed drugs for rare diseases, which was subsequently acquired by PTC Therapeutics. Prior to that, Mr. Aronin founded Ovation Pharmaceuticals, Inc., or Ovation, where he served as President and Chief Executive Officer from 2000 to 2009. After Lundbeck A/S acquired Ovation in 2009, Mr. Aronin served as Chief Executive Officer of Lundbeck Inc. until 2011. Mr. Aronin previously served on the public board of directors of Discover Financial Services, Inc. from 2008 until 2024. Mr. Aronin also currently serves on the boards of several non-profit organizations including The Aspen Institute and MATTER, which Aronin founded to support life science innovation. Mr. Aronin received a B.S. in marketing from Northern Illinois University and an M.B.A. from DePaul University. We believe that Mr. Aronin is qualified to serve on our board of directors due to his vast skills and experience in biopharmaceutical strategy, innovation, business development, commercialization, lifecycle management, capital structure and finance.
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R. MARK GRAF
Former Chief Financial Officer of Discover Financial Services
Director since 2020
Age 60
Committees: Audit Committee
R. Mark Graf has served as a member of our board of directors since November 2020. Mr. Graf served as Chief Financial Officer of Discover Financial Services, a publicly traded financial services company, from April 2011 to September 2019. Prior to joining Discover, he served as an Investment Advisor at Aquiline Capital Partners from 2008 to 2011 and a Partner at Barrett Ellman Stoddard Capital Partners from 2006 to 2008. Mr. Graf served as Chief Financial Officer of Fifth Third Bancorp from 2004 to 2006, and was its Corporate Treasurer from 2001 to 2004. He also served in various roles at AmSouth Bancorporation from 1994 to 2001. Mr. Graf previously served on the board of directors of BNC Bancorp, formerly a publicly traded bank holding company, from 2010 to 2011 and currently serves on the board of directors of Marqeta, Inc. and Signet Jewelers Limited. Mr. Graf was selected to the Board because of his extensive business, capital analysis, risk management and financial management expertise, and we believe he will bring valuable experience and insight to the Board.
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JEFFREY M. DAYNO, M.D.
President and Chief Executive Officer of Harmony
Director since 2023
Age 67
Committees: None
Dr. Dayno's business background information is set forth under "Executive Officers" below.
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ANTONIO GRACIAS
Chief Executive Officer and Chief Investment Officer of Valor Management LLC
Director since 2017
Age 54
Committees: Compensation Committee (Chair)
Antonio J. Gracias has served on our board of directors since September 2017. Since September 2001, Mr. Gracias has been Chief Executive Officer and Chief Investment Officer of Valor Management LLC, or Valor, a private equity firm. Mr. Gracias has served as a director of Castle Creek Pharmaceuticals since September 2018. He also served as a director of Marathon Pharmaceuticals, LLC from November 2013 until its acquisition by PTC Therapeutics in May 2017, and SolarCity Corporation from 2012 to 2016. Mr. Gracias served on the board of directors of Tesla, Inc. from 2007 to 2021, including as Lead Independent Director from September 2010 to April 2019. Mr. Gracias also serves as director of SpaceX. He has over 20 years of experience investing in a variety of sectors including private equity, public equity, and real estate transactions. Mr. Gracias received a joint B.S. / M.S.F.S. degree in international finance and economics from Georgetown University School of Foreign Service and a J.D. from the University of Chicago Law School. We believe that Mr. Gracias is qualified to serve on our board of directors due to his skills and experience in investment strategy, portfolio company management and improvement, and finance in several industries, including pharmaceuticals and healthcare.
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ANDREAS WICKI, PH.D.
Chief Executive Officer of HBM Healthcare Investments AG
Director since 2017
Age 66
Committees: Audit Committee, Compensation Committee
Andreas Wicki, Ph.D.,has served on our board of directors since September 2017. Dr. Wicki has served as Chief Executive Officer of HBM Healthcare Investments AG (formerly HBM BioVentures AG) since July 2001. From 1998 to 2001, Dr. Wicki was the Senior Vice President of the European Analytical Operations at MDS Inc. From 1990 to 1998, he was co-owner and Chief Executive Officer of ANAWA Laboratorien AG and Clinserve AG, two life sciences contract research companies. Dr. Wicki currently serves on the board of directors of Buchler GmbH, HBM Healthcare Investments (Cayman) Ltd., HBM BioCapital Ltd., Viela Bio, Inc., a public clinical-stage biotechnology company, and Vitaeris, Inc., a private clinical-stage biopharmaceutical company. Dr. Wicki previously served on the board of Pacira BioSciences, Inc., a public pharmaceutical company from 2006 until January 2025. Dr. Wicki is a life sciences entrepreneur and investor with over 20 years of experience in the pharmaceutical and biotechnology industries. Dr. Wicki holds an M.Sc. and Ph.D. in chemistry from the University of Bern, Switzerland. We believe Dr. Wicki is qualified to serve on our board of directors due to his extensive experience with pharmaceutical companies, his financial expertise and his years of experience providing strategic and advisory services to pharmaceutical and biotechnology organizations.
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PETER ANASTASIOU
Chief Executive Officer of Capsida Biotherapeutics
Director since 2023
Age 54
Committees: Compensation Committee
Peter Anastasiou has served on our board of directors since November 2023. Mr. Anastasiou has served as Chief Executive Officer and as a member of the board of directors of Capsida Biotherapeutics, a next-generation integrated gene therapy company, since January 2022. Prior to Capsida, from November 2009 to December 2021, Mr. Anastasiou served in various roles at Lundbeck, a pharmaceutical company publicly traded on the Copenhagen Stock Exchange, including most recently as Executive Vice President and President of North America, and prior to that as Chief Commercial Officer for the U.S. and Vice President and General Manager for Psychiatry. In addition, he served as a member of the board of directors of Lundbeck from January 2016 to December 2021. Mr. Anastasiou currently serves on the Global Advisory Board of the Healthcare Businesswomen's Association and has previously served on the boards of several private organizations, including the Pharmaceutical Research and Manufacturers Association (PhRMA), Kids Above All and Bear Necessities Pediatric Cancer Foundation. Mr. Anastasiou received a B.A. in Economics and Management from Albion College and an M.B.A. from Kelley School of Business, Indiana University. We believe that Mr. Anastasiou is qualified to serve on our Board because of his extensive experience in the life sciences industry developing and leading multifaceted biotechnology organizations, as well as his demonstrated business acumen.
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RON PHILIP
Chief Executive Officer of Orbital Therapeutics
Director since 2025
Age 51
Committees (Effective April 7, 2025): Audit Committee, Nominating and Corporate Governance Committee
Ron Philiphas served on our board of directors since April 2025. Mr. Philip has served as Chief Executive Officer and as a member of the board of directors of Orbital Therapeutics, a biotech company focused on the development of RNA-based medicines, since September 2024. Prior to Orbital, from May 2017 to September 2024, Mr. Philip served in several roles for Spark Therapeutics, a gene therapy company, most recently as Chief Executive Officer. Mr. Philip also served in various roles for Pfizer from November 2009 to October 2016. Mr. Philip has also previously served on the boards of several private organizations, including the Academy of Natural Sciences of Drexel University, Cure Duchenne and the Chamber of Commerce for Greater Philadelphia. Mr. Philip received a B.S. in Computer Information Systems from Drexel University. We believe that Mr. Philip is qualified to serve on our Board because of his extensive experience in the life sciences industry developing and leading teams focused on novel treatments, as well as his demonstrated business acumen.
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appointing, compensating, retaining, evaluating, terminating and overseeing our independent registered public accounting firm;
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discussing with our independent registered public accounting firm their independence from management;
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reviewing with our independent registered public accounting firm the scope and results of their audit;
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approving all audit and permissible non-audit services to be performed by our independent registered public accounting firm;
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overseeing the financial reporting process and discussing with management and our independent registered public accounting firm the interim and annual financial statements that we file with the SEC;
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reviewing and monitoring our accounting principles, accounting policies, financial and accounting controls and compliance with legal and regulatory requirements;
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reviewing our policies on risk assessment and risk management;
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reviewing related party transactions; and
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establishing procedures for the confidential anonymous submission of concerns regarding questionable accounting, internal controls or auditing matters.
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reviewing and approving corporate goals and objectives with respect to the compensation of our Chief Executive Officer, evaluating our Chief Executive Officer's performance in light of these goals and objectives and setting compensation;
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reviewing and setting, or making recommendations to our board of directors regarding, the compensation of our other executive officers;
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reviewing and making recommendations to our board of directors regarding director compensation;
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reviewing and approving, or making recommendations to our board of directors regarding, our incentive compensation and equity-based plans and arrangements; and
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appointing and overseeing any compensation consultants.
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identifying qualified individuals to serve as members of our board of directors;
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reviewing the structure and membership of our board of directors and its committees;
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reviewing our Corporate Governance Guidelines; and
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overseeing self-evaluations of our board of directors and management.
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director qualifications and criteria;
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director orientation and continuing education;
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service on other boards;
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independence and separate sessions of independent directors;
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the potential for a lead director;
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board access to senior management and independent advisors;
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succession planning;
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board of director committees; and
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board of directors meetings.
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conflicts of interest;
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disclosures;
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compliance with laws, rules and regulations;
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insider trading;
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reporting, accountability and enforcement;
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corporate opportunities;
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confidentiality and protection and proper use of company assets;
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fair dealing;
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corporate loans and guarantees;
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gifts and favors and personal investments;
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retaliation, discrimination and harassment;
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political contributions; and
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personal conduct and social media.
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2024
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2023
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(IN THOUSANDS)
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Audit Fees(1)
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$ 1,470
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$ 1,460
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Audit-Related Fees
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$215
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$160
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Tax Fees
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$806
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$765
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All Other Fees(2)
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$-
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$2
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Total Fees
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$2,491
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$2,387
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(1)
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Audit Fees consist of fees for professional services rendered in connection with the audit of our annual financial statements, including audited financial statements presented in our Annual Report on Form 10-K, reviews of our unaudited quarterly financial statements and services that are normally provided by the independent registered public accounting firm in connection with statutory and regulatory filings or engagements for those fiscal years.
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(2)
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Represents annual subscription fee for access to Deloitte's accounting research tool.
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reviewed and discussed the audited financial statements with management and Deloitte;
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discussed with Deloitte the matters required to be discussed by the applicable requirements of the PCAOB and the SEC; and
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received the written disclosures and the letters from Deloitte required by applicable requirements of the PCAOB regarding the independent accountant's communications with the audit committee concerning independence, and has discussed with Deloitte its independence.
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NAME
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AGE
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POSITION
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Jeffrey Dayno, M.D.
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67
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President and Chief Executive Officer
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Sandip Kapadia
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55
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Chief Financial Officer and Chief Administrative Officer
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Andrew Serafin
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50
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Chief Strategy Officer
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Kumar Budur, M.D., M.S.
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54
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Chief Medical Officer
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Adam Zaeske
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52
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Chief Commercial Officer
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Respectfully submitted,
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THE COMPENSATION COMMITTEE
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Antonio Gracias (Chair)
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Gary Sender
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Andreas Wicki, Ph.D.
Peter Anastasiou
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Jeffrey Dayno, President and Chief Executive Officer;
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Sandip Kapadia, Executive Vice President, Chief Financial Officer and Chief Administrative Officer;
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Jeffrey Dierks, Executive Vice President and Chief Commercial Officer;
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Kumar Budur, Executive Vice President and Chief Medical & Scientific Officer; and
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Andrew Serafin, Executive Vice President and Chief Strategy Officer.
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Continued Strong Growth For WAKIX® (pitolisant) in Adult Narcolepsy:We saw another solid year of growth for WAKIX in 2024 with net revenue of $714.7 million, representing an increase of 23% year over year. Our strong results demonstrate the durability of the brand entering year five on the market.
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Strong Momentum in Advancing and Expanding the Pipeline:We are pleased with the progress we have made across all our pipeline/life cycle management programs. We are also advancing late-stage clinical programs exploring pitolisant in Prader-Willi syndrome and myotonic dystrophy type 1 and we have made progress in the development of two new formulations of pitolisant, Pitolisant GR and Pitolisant HD, with plans to initiate Phase 3 registrational trial for Pitsolisant HD in the fourth quarter of 2025. ZYN-002 is currently in a Phase 3 registrational trial for Fragile X Syndrome and data from our ZYN-002 Phase 3 study is anticipated in the third quarter of 2025. We expanded our pipeline and diversified our portfolio with the acquisition of Epygenix Therapeutics, Inc., adding global rights to develop, manufacture and commercialize EPX-100, which is currently in Phase 3 registrational clinical trial for Dravet Syndrome and Lennox-Gastaut Syndrome. Finally, in April 2024, we expanded into orexin science through a sublicense agreement with Bioprojet for an orexin 2 receptor agonist in preclinical development for narcolepsy and other potential indications.
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Disciplined Capital Allocation to Maximize Shareholder Value:We are a profitable and cash generating business, with $576.1 million in cash, cash equivalents and investments on the balance sheet as of December 31, 2024. We have a solid financial position and we remain well positioned to execute on our business development goal of building out a robust pipeline of assets.
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Objective
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Type of Compensation
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Key Features
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2024 Actions Taken
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Base Salary
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Provides fixed pay that attracts and retains talented executives in a competitive market, recognizes individual roles and level of responsibilities, and provides stable income
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Cash
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Reflects individual skills, experience, responsibilities and performance over time, as well as market practice
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In May 2024, we increased Dr. Budur's annual base salary to $575,000 in connection with his appointment as our EVP and Chief Medical & Scientific Officer.
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Short-Term Incentive-Annual Incentive Plan
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Motivate and retain employees and align incentives to near-term company objectives
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Promotes and reinforces the attainment of short-term performance objectives and rewards executives for their contributions toward achieving those objectives
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Cash
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Performance-based reward tied to achievement of short-term (annual) corporate financial and operational performance targets
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Effective January 1, 2024, we increased Dr. Budur's target annual bonus opportunity from 40% to 50% of his annual base salary in connection with his appointment as our EVP and Chief Medical Officer.
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In light of the achievement of each of the performance goals, annual bonuses were earned at 115% for Mr. Kapadia and 123% for each other NEO
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Long-Term Incentives
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Aligns executives' interests with our stockholders' interests, emphasizes long-term financial and operational performance, and helps retain executive talent
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Promotes retention and enhances executive stock ownership
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Equity
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Links value to stock price appreciation and directly aligns with stockholders' interests
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Rewards achievement of pre-specified performance objectives
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In 2024, we granted an award of stock options and restricted stock units ("RSUs") to each of our NEOs under our 2024 long-term incentive program
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We granted an additional award of stock options and RSUs to Dr. Budur in connection with his appointment as our EVP and Chief Medical & Scientific Officer in May 2024
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Objective
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Type of Compensation
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Key Features
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2024 Actions Taken
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Severance Protections
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Aid in attracting and retaining executive talent and help executives to remain focused and dedicated during potential transition periods due to a change in control
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Cash, equity award acceleration and healthcare benefits
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Facilitates an orderly transition in the event of management changes
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Helps ensure NEOs remain focused on creating sustainable performance in case of personal uncertainties or risk of job loss
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Severance
plan includes confidentiality, non-competition, non-solicitation and non-disparagement protections |
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No changes were made to our NEOs' severance protections in 2024.
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Other Benefits
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Provide programs for employees to pursue physical and financial wellbeing through retirement and health and welfare benefits
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We also provide certain other perquisites to our NEOs
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Benefits
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Broad-based benefits available to all employees
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Some executive perquisites
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No changes in 2024.
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What We Do
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What We Do Not Do
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✔
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Emphasize performance-based, at-risk compensation.
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✘
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Do not guarantee annual salary or target bonus increases.
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✔
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Emphasize the use of equity compensation to promote executive retention and reward long-term value creation.
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✘
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Do not grant uncapped annual cash incentives or guaranteed equity compensation.
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✔
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Weight the overall pay mix towards incentive compensation for senior executives.
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✘
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Do not provide significant or excessive perquisites.
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✔
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Prohibit all of our directors, officers and employees (including our NEOs) from engaging in hedging or monetization transactions in Company securities.
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✘
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Do not provide any compensation-related tax gross-ups.
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✔
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Maintain a clawback policy for recovery of any erroneously awarded incentive compensation in the
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✘
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Do not maintain any defined benefit pension plans or supplemental executive retirement plans.
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What We Do
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What We Do Not Do
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event of a financial restatement.
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Attract and retain talented and experienced executives in a competitive and dynamic market;
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Motivate our NEOs to help the Company achieve the best possible financial and operational results; and
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Align the long-term interests of our NEOs with those of our stockholders.
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•Acadia
•Axsome
•Ionis
•Neurocrine Biosciences
•Supernus
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•Alkermes
•Catalyst Pharma
•Jazz Pharmaceuticals
•PTC
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•Avadel
•Intra-Cellular
•Mariuns
•Sage Therapeutics
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Named Executive Officer
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2024 Annualized
Base Salary
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Jeffrey Dayno
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$715,000
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Sandip Kapadia
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$507,606
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Jeffrey Dierks
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$508,702
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Kumar Budur
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$575,000
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Andrew Serafin
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$420,294
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Named Executive Officer
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Target Annual Bonus
Opportunity
(as a Percentage of
Base Salary)
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Jeffrey Dayno
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75%
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Sandip Kapadia
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50%
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Jeffrey Dierks
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50%
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Kumar Budur(1)
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50%
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Andrew Serafin
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50%
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(1)
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Effective January 1, 2024, Dr. Budur's target annual bonus opportunity was increased from 40% to 50% of his annual base salary in connection with his appointment as our EVP and Chief Medical Officer.
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Performance Goal
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Weighting
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Net Product Revenue(1)
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25%
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Clinical Development Programs
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20%
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Corporate Transaction Goals
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25%
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Financial Health Goals(2)
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25%
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Talent and Culture Goals
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5%
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(1)
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Net Product Revenue means the gross sales of WAKIX less provisions for product sales discounts and allowances, which includes trade allowances, rebates to government and commercial entities, and discounts.
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(2)
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Consists of two subgoals relating to: (i) stock performance against our 2024 peer group and (ii) stock performance against the NASDAQ Biotechnology Index.
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Performance Level
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%of Performance Goal
Achieved
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% Payout
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Objective Not Completed
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< 100%
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(3)
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Meets Expectations
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100%(1)
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100%
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Exceeds Expectations
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(2)
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150%
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(1)
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With respect to the Net Product Revenue goal, this performance level would be achieved at $710 million (and up to $750 million).
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(2)
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With respect to the Net Product Revenue goal, this performance level would be achieved at above $750 million. With respect to the other goals, this performance level would be achieved if the Compensation Committee determines that actual performance exceeded expectations and had a material benefit to the Company.
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(3)
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With respect to this performance level, the payout percentage would be less than 100%, as determined by the Compensation Committee based upon the relative performance level achieved.
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Named Executive Officer
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% of Target Annual Bonus
Opportunity Earned in 2024
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Jeffrey Dayno
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123%
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Sandip Kapadia
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115%
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Jeffrey Dierks
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123%
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Kumar Budur
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123%
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Andrew Serafin
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123%
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Named Executive Officer
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Number of
Shares
Underlying
Stock Options
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Number of RSUs
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Jeffrey Dayno
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202,250
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42,000
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Sandip Kapadia
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74,250
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15,250
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Jeffrey Dierks
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52,500
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10,750
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Kumar Budur
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42,500
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8,750
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Andrew Serafin
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47,750
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10,000
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Position
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Ownership Requirement
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Chief Executive Officer
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5x annual base salary
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Other Executive Officers
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3x annual base salary
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Non-Employee Directors
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1.5x annual cash retainer*
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*
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Not including committee retainers or chairmanship retainers.
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Name and Principal Position
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Year
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Salary
($)
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Bonus
($)(1)
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Stock
Awards
($)(2)
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Option
Awards
($)(2)
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Non-Equity
Incentive Plan
Compensation
($)(3)
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All Other
Compensation
($)(4)
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Total
($)
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Jeffrey Dayno
President and Chief Executive Officer
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2024
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715,000
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300,000
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1,288,980
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4,189,508
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637,000
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14,683
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7,145,170
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2023
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612,500
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200,000
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-
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3,186,875
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437,000
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13,919
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4,450,294
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2022
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458,993
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-
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-
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-
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286,870
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16,289
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762,152
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Sandip Kapadia
EVP and Chief Financial Officer and Chief Administrative Officer
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2024
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507,606
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250,000
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468,023
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1,538,052
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291,873
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14,848
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3,070,401
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2023
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507,606
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-
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4,767,000
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-
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291,873
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14,045
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5,580,524
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2022
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476,625
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175,000
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-
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-
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297,891
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13,086
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962,602
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Jeffrey Dierks
EVP and Chief Commercial Officer
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2024
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508,702
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250,000
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329,918
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1,087,511
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279,908
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14,871
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2,470,910
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2023
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486,796
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50,000
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4,767,000
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-
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279,908
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14,045
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5,597,749
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2022
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412,072
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-
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-
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-
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236,941
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13,086
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662,099
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Kumar Budur
EVP and Chief Medical & Scientific Officer
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2024
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555,147
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-
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2,538,788
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2,420,116
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207,018
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11,636
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5,732,705
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2023
|
|
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440,251
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100,000
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|
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-
|
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-
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207,018
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|
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13,545
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760,813
|
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Andrew Serafin
EVP, Chief Strategy Officer
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2024
|
|
|
420,294
|
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125,000
|
|
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306,900
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|
989,117
|
|
|
231,262
|
|
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14,848
|
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|
2,087,422
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2023
|
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402,195
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|
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-
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-
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|
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-
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|
|
231,262
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|
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13,968
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|
647,425
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|
2022
|
|
|
375,673
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
216,012
|
|
|
13,737
|
|
|
605,422
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Amounts consist of a one-time cash retention bonus payable to each of Dr. Dayno and Messrs. Dierks, Kapadia and Serafin. We provide additional information regarding these bonuses in the section above titled "-Cash Incentive Compensation-Other Cash Compensation."
|
(2)
|
Amounts reflect the full grant-date fair value of options and RSUs granted during 2024 computed in accordance with ASC Topic 718, rather than the amounts paid to or realized by the named individual. We provide information regarding the assumptions used to calculate the value of all option and RSU awards made to our named executive officers in Note 15 to our financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2024.
|
(3)
|
Amounts reported include actual annual bonuses earned by our NEOs under our 2024 annual bonus program. We provide additional information regarding the annual bonuses in the section above titled "-Cash Incentive Compensation-Annual Bonus Program."
|
TABLE OF CONTENTS
(4)
|
Amounts reported for 2024 consist of the following:
|
|
|
|
|
|
|
|
|
|
|
Name
|
|
|
401(k) Plan
Matching
Contributions
($)
|
|
|
Life
Insurance
Premiums
($)
|
|
|
Long-Term
Disability
Premiums
($)
|
Jeffrey Dayno
|
|
|
13,800
|
|
|
294
|
|
|
588
|
Sandip Kapadia
|
|
|
13,800
|
|
|
483
|
|
|
565
|
Jeffrey Dierks
|
|
|
13,800
|
|
|
483
|
|
|
588
|
Kumar Budur
|
|
|
10,588
|
|
|
483
|
|
|
565
|
Andrew Serafin
|
|
|
13,800
|
|
|
483
|
|
|
565
|
|
|
|
|
|
|
|
|
|
|
TABLE OF CONTENTS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
Name
|
|
|
Grant Date
|
|
|
Approval Date
|
|
|
Estimated Possible Payouts
Under Non-Equity Incentive
Plan Awards(1)
|
|
|
All
Other
Stock
Awards:
Number
of
Shares
of Stock
or Units
(#)
|
|
|
All Other
Option
Awards:
Number of
Securities
Underlying
Options
(#)
|
|
|
Exercise
or Base
Price of
Option
Awards
($)
|
|
|
Grant Date
Fair Value
of Stock
and Option
Awards
($)(2)
|
||||||
|
Threshold
($)
|
|
|
Target
($)
|
|
|
Maximum
($)
|
|
|||||||||||||||||||
Jeffrey Dayno
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
536,250
|
|
|
804,375
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
202,250
|
|
|
30.69
|
|
|
4,189,508
|
||
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
42,000
|
|
|
-
|
|
|
-
|
|
|
1,288,980
|
||
Sandip Kapadia
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
253,803
|
|
|
380,705
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
74,250
|
|
|
30.69
|
|
|
1,538,052
|
||
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
15,250
|
|
|
-
|
|
|
-
|
|
|
468,023
|
||
Jeffrey Dierks
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
254,351
|
|
|
381,527
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
52,500
|
|
|
30.69
|
|
|
1,087,511
|
||
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
10,750
|
|
|
-
|
|
|
-
|
|
|
329,918
|
||
Kumar Budur
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
287,500
|
|
|
431,250
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
42,500
|
|
|
30.69
|
|
|
880,366
|
||
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
8,750
|
|
|
-
|
|
|
-
|
|
|
268,538
|
||
|
5/1/24
|
|
|
4/29/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
75,000
|
|
|
30.27
|
|
|
1,539,750
|
||
|
5/1/24
|
|
|
4/29/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
75,000
|
|
|
-
|
|
|
-
|
|
|
2,270,250
|
||
Andrew Serafin
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
210,147
|
|
|
315,221
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
47,750
|
|
|
30.69
|
|
|
989,117
|
||
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
10,000
|
|
|
-
|
|
|
-
|
|
|
306,900
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Amounts reflect potential payouts under our 2024 annual bonus program at threshold (or "Objective Not Completed"), target (or "Meets Expectations") and maximum (or "Exceeds Expectations") amounts based on 2024 base salaries. We provide additional information regarding the annual bonus program in the section above titled "-Cash Incentive Compensation-Annual Bonus Program."
|
(2)
|
Amounts reflect the full grant-date fair value of options and RSUs granted during 2024 computed in accordance with ASC Topic 718. We provide information regarding the assumptions used to calculate these values in Note 15 to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2024.
|
TABLE OF CONTENTS
TABLE OF CONTENTS
TABLE OF CONTENTS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||
|
|
|
|
|
|
|
|
Option Awards
|
|
|
Stock Awards
|
||||||||||||||||
Name
|
|
|
|
|
Grant
Date
|
|
|
Vesting
Commencement
Date
|
|
|
Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
|
|
|
Number of
Securities
Underlying
Unexercised
Options (#)
Unexercisable
|
|
|
Option
Exercise
Price ($)
|
|
|
Option
Expiration
Date
|
|
|
Number of
Shares or Units
of Stock That
Have Not
Vested (#)
|
|
|
Market Value
of Shares or
Units of Stock
That Have Not
Vested ($)(1)
|
|
Jeffrey Dayno
|
|
|
(2)
|
|
|
11/13/17
|
|
|
11/1/17
|
|
|
23,470
|
|
|
-
|
|
|
$8.22
|
|
|
11/13/27
|
|
|
-
|
|
|
-
|
|
(3)
|
|
|
1/7/19
|
|
|
1/1/19
|
|
|
6,086
|
|
|
-
|
|
|
$8.22
|
|
|
1/7/29
|
|
|
-
|
|
|
-
|
||
|
(3)
|
|
|
3/4/20
|
|
|
3/1/20
|
|
|
9,737
|
|
|
2,435
|
|
|
$8.22
|
|
|
3/4/30
|
|
|
-
|
|
|
-
|
||
|
(4)
|
|
|
8/18/20
|
|
|
8/21/20
|
|
|
105,808
|
|
|
26,452
|
|
|
$24.00
|
|
|
8/18/30
|
|
|
-
|
|
|
-
|
||
|
(5)
|
|
|
5/26/23
|
|
|
5/25/23
|
|
|
-
|
|
|
125,000
|
|
|
$35.56
|
|
|
5/25/33
|
|
|
-
|
|
|
-
|
||
|
(8)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
202,250
|
|
|
$30.69
|
|
|
1/24/34
|
|
|
-
|
|
|
-
|
||
|
(9)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
42,000
|
|
|
1,445,220
|
||
Sandip Kapadia
|
|
|
(5)
|
|
|
3/29/21
|
|
|
3/29/21
|
|
|
215,625
|
|
|
14,375
|
|
|
$29.03
|
|
|
3/29/31
|
|
|
-
|
|
|
-
|
|
(6)
|
|
|
3/29/21
|
|
|
3/29/23
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
15,000
|
|
|
516,150
|
||
|
(7)
|
|
|
10/4/23
|
|
|
9/30/23
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
90,000
|
|
|
3,096,900
|
||
|
(8)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
74,250
|
|
|
$30.69
|
|
|
1/24/34
|
|
|
-
|
|
|
-
|
||
|
(9)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
15,250
|
|
|
524,753
|
||
Jeffrey Dierks
|
|
|
(3)
|
|
|
3/4/20
|
|
|
3/1/20
|
|
|
-
|
|
|
4,869
|
|
|
$8.22
|
|
|
3/4/30
|
|
|
-
|
|
|
-
|
|
(4)
|
|
|
8/18/20
|
|
|
8/21/20
|
|
|
-
|
|
|
28,972
|
|
|
$24.00
|
|
|
8/18/30
|
|
|
-
|
|
|
-
|
||
|
(5)
|
|
|
6/1/21
|
|
|
6/1/21
|
|
|
47,162
|
|
|
6,738
|
|
|
$33.44
|
|
|
6/1/31
|
|
|
-
|
|
|
-
|
||
|
(7)
|
|
|
10/4/23
|
|
|
9/30/23
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
90,000
|
|
|
3,096,900
|
||
|
(8)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
52,500
|
|
|
$30.69
|
|
|
1/24/34
|
|
|
-
|
|
|
-
|
||
|
(9)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
10,750
|
|
|
369,908
|
||
Kumar Budur
|
|
|
(5)
|
|
|
3/21/22
|
|
|
3/21/22
|
|
|
51,562
|
|
|
23,438
|
|
|
$49.27
|
|
|
3/21/32
|
|
|
-
|
|
|
-
|
|
(8)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
42,500
|
|
|
$30.69
|
|
|
1/24/34
|
|
|
-
|
|
|
-
|
||
|
(9)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
8,750
|
|
|
301,088
|
||
|
(8)
|
|
|
5/1/24
|
|
|
5/1/24
|
|
|
-
|
|
|
75,000
|
|
|
$30.27
|
|
|
5/1/34
|
|
|
-
|
|
|
-
|
||
|
(9)
|
|
|
5/1/24
|
|
|
5/1/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
75,000
|
|
|
2,580,750
|
||
Andrew Serafin
|
|
|
(2)
|
|
|
10/1/17
|
|
|
10/1/17
|
|
|
83,729
|
|
|
-
|
|
|
$8.22
|
|
|
10/1/27
|
|
|
-
|
|
|
-
|
|
(2)
|
|
|
10/1/18
|
|
|
10/1/18
|
|
|
18,259
|
|
|
-
|
|
|
$8.22
|
|
|
10/1/28
|
|
|
-
|
|
|
-
|
||
|
(3)
|
|
|
3/4/20
|
|
|
3/1/20
|
|
|
2,920
|
|
|
731
|
|
|
$8.22
|
|
|
3/4/30
|
|
|
-
|
|
|
-
|
||
|
(4)
|
|
|
8/18/20
|
|
|
8/21/20
|
|
|
65,500
|
|
|
16,375
|
|
|
$24.00
|
|
|
8/18/30
|
|
|
-
|
|
|
-
|
||
|
(8)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
47,750
|
|
|
$30.69
|
|
|
1/24/34
|
|
|
-
|
|
|
-
|
||
|
(9)
|
|
|
1/24/24
|
|
|
1/24/24
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
10,000
|
|
|
344,100
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Amounts are calculated based on multiplying the number of shares shown in the table by the per share closing price of our common stock on December 31, 2024, which was $34.41.
|
(2)
|
Each of these option awards was granted under our Amended and Restated Equity Incentive Plan (the "Equity Incentive Plan") vested in full prior to December 31, 2024.
|
(3)
|
Each of these option awards was granted under the Equity Incentive Plan and vests and becomes exercisable with respect to 20% of the shares of our common stock underlying the option on each of the first five anniversaries of the applicable vesting commencement date, subject to continued employment through the applicable vesting date. In addition, each option will vest and become exercisable in full upon the occurrence of a "change in control" (as defined in the Equity Incentive Plan).
|
(4)
|
Each of these option awards was granted under the 2020 Plan and vests and becomes exercisable with respect to 20% of the shares of our common stock underlying the option on each of the first five anniversaries of the vesting commencement date, subject to continued employment through the applicable vesting date.
|
(5)
|
Each of these option awards was granted under the 2020 Plan and vests and becomes exercisable over four years (i) with respect to 50% of the total shares of our common stock underlying the option on the second anniversary of the vesting commencement date, and (ii) with respect to 1/48 of the total shares underlying the option on each of the first 24 monthly anniversaries of the vesting commencement date thereafter, subject to continued service through the applicable vesting date.
|
(6)
|
This RSU award was granted under the 2020 Plan and vests over four years (i) with respect to 50% of the total RSUs underlying the award on the applicable vesting commencement date, and (ii) with respect to 25% of the total RSUs underlying the award on each of the first and second anniversaries of the vesting commencement date thereafter, subject to continued employment through the applicable vesting date.
|
TABLE OF CONTENTS
(7)
|
Each of these RSU awards was granted under the 2020 Plan and vests over three years (i) with respect to 40% of the total RSUs underlying the award on the first anniversary of the vesting commencement date, and (ii) with respect to 30% of the total RSUs underlying the award on each of the second and third anniversaries of the vesting commencement date thereafter, subject to continued employment through the applicable vesting date.
|
(8)
|
Each of these option awards was granted under the 2020 Plan and vests and becomes exercisable over four years (i) with respect to 25% of the total shares of our common stock underlying the option on the first anniversary of the vesting commencement date, and (ii) with respect to 75% of the total shares of our common stock underlying the option on each of the first 12 quarterly anniversaries of the vesting commencement date thereafter, subject to continued employment through the applicable vesting date.
|
(9)
|
Each of these RSU awards was granted under the 2020 Plan and vests over four years with respect to 25% of the total RSUs underlying the award on the each of the first four anniversaries of the vesting commencement date, subject to continued employment through the applicable vesting date.
|
TABLE OF CONTENTS
|
|
|
|
|
|
|
||||||
Name
|
|
|
Option Awards
|
|
|
Stock Awards
|
||||||
|
Number of Shares
Acquired on
Exercise
(#)
|
|
|
Value
Realized
on Exercise(1)
($)
|
|
|
Number of Shares
Acquired on
Vesting
(#)
|
|
|
Value Realized
on Vesting(2)
($)
|
||
Jeffrey Dayno
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
Sandip Kapadia
|
|
|
-
|
|
|
-
|
|
|
75,000
|
|
|
2,903,700
|
Jeffrey Dierks
|
|
|
70,115
|
|
|
1,227,937
|
|
|
60,000
|
|
|
2,400,000
|
Kumar Budur
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
Andrew Serafin
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Amounts are calculated by multiplying the number of shares as to which the option was exercised by the market price of the shares on the exercise date, net of the exercise price.
|
(2)
|
Amounts are calculated by multiplying the number of shares vested by our closing stock price on the vesting date.
|
TABLE OF CONTENTS
(i)
|
base salary continuation for a period of 12 months following the termination date;
|
(ii)
|
12 months of continued coverage under our group health plans at the same level and cost to the executive as was in place prior to the termination date;
|
(iii)
|
up to three months (for Dr. Dayno) or 12 months (for Mr. Kapadia) of outplacement services;
|
(iv)
|
for Mr. Kapadia, an additional 12 months of vesting for each of the Kapadia Option Award and Kapadia RSU Award (to the extent then-unvested), and any such vested portion of the Kapadia Option Award will remain outstanding and exercisable for not less than 12 months following the termination date; and
|
(v)
|
if such termination occurs within 12 months following a "change in control" (as defined in the applicable employment agreement (for Dr. Dayno) or in the 2020 Plan (for Mr. Kapadia)), then, in addition to the payments and benefits described above, the executive will also receive (A) a lump-sum cash payment equal to his target annual bonus for the year in which the termination occurs, pro-rated through the date of such termination; and (B) for Mr. Kapadia, full accelerated vesting of any portion of the Kapadia Option Award and/or Kapadia RSU Award that is then-outstanding and unvested.
|
(i)
|
A lump sum cash payment, payable within 60 days following the termination date, equal to the sum of: (A) the portion of the participant's target annual bonus (as in then in effect) that would have been paid to the participant for the year in which the termination occurs, pro-rated for the portion of the year the participant was employed by us; (B) one-half of the participant's highest annual base salary as in effect during the 12-month period immediately preceding the termination date or the date of the change in control (whichever is earlier); and (C) the amount necessary to cover the full cost of healthcare coverage under our group health plans for a period of six months following the termination date; and
|
(ii)
|
Outplacement assistance, as determined in the discretion of the plan administrator.
|
TABLE OF CONTENTS
TABLE OF CONTENTS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Name
|
|
|
Benefit
|
|
|
Termination Without
Cause or for
Good Reason
(no Change
in Control)
($)
|
|
|
Termination
due to Death
or Disability
($)
|
|
|
Change in
Control (no
Termination)
($)(1)
|
|
|
Termination Without
Cause or for
Good Reason
(in Connection
with a Change
in Control)
($)(2)
|
|
|
Voluntary
Resignation ($)
|
Jeffrey Dayno
|
|
|
Cash
|
|
|
715,000
|
|
|
-
|
|
|
-
|
|
|
1,251,250
|
|
|
-
|
|
Equity Acceleration(3)
|
|
|
-
|
|
|
-
|
|
|
63,773
|
|
|
2,536,728
|
|
|
-
|
||
|
Continued Healthcare
|
|
|
31,355
|
|
|
-
|
|
|
-
|
|
|
31,355
|
|
|
-
|
||
|
Outplacement Services(4)
|
|
|
7,500
|
|
|
-
|
|
|
-
|
|
|
7,500
|
|
|
-
|
||
|
Total(5)
|
|
|
753,855
|
|
|
-
|
|
|
63,773
|
|
|
3,826,833
|
|
|
-
|
||
Sandip Kapadia
|
|
|
Cash
|
|
|
507,606
|
|
|
-
|
|
|
-
|
|
|
761,409
|
|
|
-
|
|
Equity Acceleration(3)
|
|
|
3,690,387
|
|
|
-
|
|
|
-
|
|
|
4,491,349
|
|
|
3,096,900
|
||
|
Continued Healthcare
|
|
|
39,665
|
|
|
-
|
|
|
-
|
|
|
39,665
|
|
|
-
|
||
|
Outplacement Services(4)
|
|
|
14,000
|
|
|
-
|
|
|
-
|
|
|
14,000
|
|
|
-
|
||
|
Total(5)
|
|
|
4,251,658
|
|
|
-
|
|
|
-
|
|
|
5,306,423
|
|
|
-
|
||
Jeffrey Dierks
|
|
|
Cash
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
381,527
|
|
|
-
|
|
Equity Acceleration(3)
|
|
|
3,096,900
|
|
|
-
|
|
|
127,519
|
|
|
4,097,760
|
|
|
-
|
||
|
Continued Healthcare
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
6,705
|
|
|
-
|
||
|
Outplacement Services(4)
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
7,500
|
|
|
-
|
||
|
Total(5)
|
|
|
3,096,900
|
|
|
-
|
|
|
127,519
|
|
|
4,493,492
|
|
|
-
|
||
Kumar Budur
|
|
|
Cash
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
431,250
|
|
|
-
|
|
Equity Acceleration
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
3,350,437
|
|
|
-
|
||
|
Continued Healthcare
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
12,308
|
|
|
-
|
||
|
Outplacement Services
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
7,500
|
|
|
-
|
||
|
Total(5)
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
3,801,495
|
|
|
-
|
||
Andrew Serafin
|
|
|
Cash
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
315,221
|
|
|
-
|
|
Equity Acceleration(3)
|
|
|
-
|
|
|
-
|
|
|
19,145
|
|
|
711,338
|
|
|
-
|
||
|
Continued Healthcare
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
17,045
|
|
|
-
|
||
|
Outplacement Services(4)
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
7,500
|
|
|
-
|
||
|
Total(5)
|
|
|
-
|
|
|
-
|
|
|
19,145
|
|
|
1,051,104
|
|
|
-
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
With respect to option and RSU awards, amounts (i) assume the awards are assumed or substituted in connection with the change in control; and (ii) represent the value associated with the full, accelerated vesting of any such awards outstanding under the Equity Incentive Plan upon a change in control.
|
(2)
|
With respect to option and RSU awards, amounts represent the value associated with the full, accelerated vesting of such awards upon a change in control, including with respect to a qualifying termination of employment in connection with the change in control. For Dr. Dayno and Mr. Kapadia, amounts reflect the payments that would have been made to the executive under his employment agreement on a qualifying termination of employment within 12 months following a "change in control" (as defined in the 2020 Plan). For Dr. Budur and Messrs. Dierks and Serafin, amounts reflect the payments that would have been made to the executive under the Separation Plan on a qualifying termination of employment within 30 days prior to, or within three months following, a "change in control" (as defined in the Separation Plan), to the extent the executive is not offered a comparable position by the acquirer.
|
(3)
|
With respect to option and RSU awards, amounts were calculated by (i) multiplying the number of accelerated shares of common stock underlying the awards by $34.41, the closing trading price of our common stock on December 31, 2024 and (ii) for the option awards, subtracting the exercise price.
|
(4)
|
For Dr. Dayno, amounts assume that he was provided with up to three months of Company-paid outplacement services. For Mr. Kapadia, amounts assume that he was provided with up to 12 months of Company-paid outplacement services. For each of Dr. Budur and Messrs. Dierks and Serafin, amounts assume that the named individual was provided with up to six months of Company-paid outplacement services pursuant to the Separation Plan.
|
(5)
|
Amounts for each other NEO are the maximum potential payment the NEO would have received as of December 31, 2024. Amounts of any reduction pursuant to a 280G best pay provision, if any, would be calculated upon actual termination of employment.
|
TABLE OF CONTENTS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
Year
|
|
|
Summary
Compensation
Table Total
for Dr. Dayno
($)
|
|
|
Compensation
Actually Paid
to Dr. Dayno
($)(1)(2)
|
|
|
Summary
Compensation
Table Total for
Mr. Jacobs
|
|
|
Compensation
Actually Paid
to Mr. Jacobs
|
|
|
Average
Summary
Compensation
Table Total for
Non-PEO
NEOs
($)
|
|
|
Average
Compensation
Actually Paid
to Non-PEO
NEOs
($)(1)(2)
|
|
|
Value of Initial Fixed $100
Investment Based on:
|
|
|
Net
Income
(in thousands)
($)
|
|
|
Net
Product
Revenue
(in thousands)(4)
|
|||
|
Total
Shareholder
Return
($)
|
|
|
Peer Group
Total
Shareholder
Return
($)(3)
|
|
|||||||||||||||||||||||||
2024
|
|
|
7,145,170
|
|
|
7,678,134
|
|
|
-
|
|
|
-
|
|
|
3,340,360
|
|
|
3,986,190
|
|
|
93
|
|
|
103
|
|
|
145,493
|
|
|
714,734
|
2023
|
|
|
4,450,294
|
|
|
2,905,735
|
|
|
36,634
|
|
|
(5,020,055)
|
|
|
3,146,628
|
|
|
491,493
|
|
|
87
|
|
|
104
|
|
|
128,853
|
|
|
582,022
|
2022
|
|
|
-
|
|
|
-
|
|
|
514,752
|
|
|
2,943,454
|
|
|
748,069
|
|
|
3,061,521
|
|
|
149
|
|
|
100
|
|
|
181,468
|
|
|
437,855
|
2021
|
|
|
-
|
|
|
-
|
|
|
885,554
|
|
|
1,960,526
|
|
|
1,898,884
|
|
|
1,355,745
|
|
|
115
|
|
|
113
|
|
|
34,597
|
|
|
305,440
|
2020
|
|
|
-
|
|
|
-
|
|
|
3,230,374
|
|
|
6,392,185
|
|
|
2,701,663
|
|
|
2,288,058
|
|
|
98
|
|
|
113
|
|
|
(36,944)
|
|
|
159,742
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Amounts represent compensation actually paid to our PEO and the average compensation actually paid to our remaining NEOs for the relevant fiscal year, as determined under SEC rules (and described below), which includes the individuals indicated in the table below for each fiscal year:
|
|
|
|
|
|
|
|
Year
|
|
|
PEO
|
|
|
Non-PEO NEOs
|
2024
|
|
|
Jeffrey Dayno,
|
|
|
Sandip Kapadia, Jeffrey Dierks, Kumar Budur and Andrew Serafin
|
2023
|
|
|
Jeffrey Dayno,
John C. Jacobs
|
|
|
Sandip Kapadia, Jeffrey Dierks, Kumar Budur and Andrew Serafin
|
2022
|
|
|
John C. Jacobs
|
|
|
Sandip Kapadia, Jeffrey Dayno, Jeffrey Dierks, and Andrew Serafin
|
2021
|
|
|
John C. Jacobs
|
|
|
Sandip Kapadia, Jeffrey Dayno, Jeffrey Dierks, Andrew Serafin and Susan Drexler
|
2020
|
|
|
John C. Jacobs
|
|
|
Jeffrey Dayno and Jeffrey Dierks
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Adjustments
|
|
|
PEO
|
|
|
Average Non-
PEO NEOs
|
Deduction for Amounts Reported under the "Stock Awards" and "Option Awards" Columns in the Summary Compensation Table for Applicable FY
|
|
|
(5,478,488)
|
|
|
(2,419,606)
|
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Remain Unvested as of Applicable FY End, determined as of Applicable FY End
|
|
|
6,128,257
|
|
|
2,720,442
|
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Vested during Applicable FY, determined as of Vesting Date
|
|
|
(125,690)
|
|
|
114,595
|
Increase/deduction for Awards Granted during Prior FY that were Outstanding and Unvested as of Applicable FY End, determined based on change in ASC 718 Fair Value from Prior FY End to Applicable FY End
|
|
|
-
|
|
|
-
|
Increase/deduction for Awards Granted during Prior FY that Vested During Applicable FY, determined based on change in ASC 718 Fair Value from Prior FY End to Vesting Date
|
|
|
8,884
|
|
|
230,400
|
Deduction of ASC 718 Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, determined as of Prior FY End
|
|
|
-
|
|
|
-
|
Increase based on Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date
|
|
|
-
|
|
|
-
|
Increase based on Incremental Fair Value of Options/SARs Modified during Applicable FY
|
|
|
-
|
|
|
-
|
Deduction for Change in the Actuarial Present Values reported under the "Change in Pension Value and Nonqualified Deferred Compensation Earnings" Column of the Summary Compensation Table for Applicable FY
|
|
|
-
|
|
|
-
|
Increase for Service Cost and, if applicable, Prior Service Cost for Pension Plans
|
|
|
-
|
|
|
-
|
TOTAL ADJUSTMENTS
|
|
|
532,964
|
|
|
645,831
|
|
|
|
|
|
|
|
(2)
|
Fair value or change in fair value, as applicable, of equity awards in the "Compensation Actually Paid" columns was determined by reference to (i) for solely service-vesting RSU awards, the closing price per share on the applicable year-end date(s) or, in the case of vesting dates, the closing price per share on the applicable vesting date(s); and (ii) for stock options, a Black-Scholes value as of the applicable year-end or vesting date(s), determined based on the same methodology as used to determine grant date fair value but using the closing stock price on the applicable revaluation date as the current market price and an expected life equal to the lesser of the original expected life utilizing the simplified method or remaining life at each revaluation date, and in all cases based on volatility and risk free rates determined as of the revaluation date based on the expected life period and based on an expected dividend rate of 0%. We provide information regarding the assumptions used to calculate the valuation of the award in Note 15 to the consolidated financial statements included in the Annual Report on Form 10-K filed on February 25, 2025.
|
(3)
|
For the relevant fiscal year, represents the cumulative TSR (the "Peer Group TSR") of the NASDAQ Biotechnology Index, which is the same peer group used in Part II, Item 5 of our Form 10-K.
|
(4)
|
Net Product Revenue is a GAAP measure reported in the Company's consolidated statements of operations and comprehensive income (loss).
|
TABLE OF CONTENTS
TABLE OF CONTENTS
•
|
Net Product Revenue.
|
TABLE OF CONTENTS
•
|
Annual Retainer: $45,000
|
•
|
Annual Committee Chair Retainer:
|
•
|
Audit: $20,000
|
•
|
Compensation: $15,000
|
•
|
Nominating and Corporate Governance: $10,000
|
•
|
Annual Committee Member (Non-Chair) Retainer:
|
•
|
Audit: $10,000
|
•
|
Compensation: $8,000
|
•
|
Nominating and Corporate Governance: $5,000
|
•
|
Annual Non-Executive Chairman of the Board Retainer: $40,000
|
•
|
Audit Committee Chair: $230,000
|
•
|
Compensation Committee Chair: $175,000
|
•
|
Nominating and Corporate Governance Chair: $125,000
|
•
|
Eligible Director (Non-Chair): $125,000
|
•
|
Audit Committee Chair: $230,000
|
•
|
Compensation Committee Chair: $175,000
|
•
|
Nominating and Corporate Governance Chair: $125,000
|
•
|
Eligible Director (Non-Chair): $125,000
|
TABLE OF CONTENTS
•
|
Annual Retainer: $50,000
|
•
|
Annual Committee Chair Retainer:
|
•
|
Audit: $25,000
|
•
|
Compensation: $20,000
|
•
|
Nominating and Corporate Governance: $12,000
|
•
|
Annual Committee Member (Non-Chair) Retainer:
|
•
|
Audit: $12,000
|
•
|
Compensation: $10,000
|
•
|
Nominating and Corporate Governance: $5,250
|
•
|
Initial Grant: $300,000 (for all Eligible Directors)
|
•
|
Annual Grant: $300,000 (for all Eligible Directors)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Name
|
|
|
Fees Earned or
Paid in Cash
($)
|
|
|
Option Awards
($)(1)
|
|
|
All Other
Compensation
($)
|
|
|
Total
($)
|
Peter Anastasiou
|
|
|
53,000
|
|
|
125,010
|
|
|
-
|
|
|
178,010
|
Jeffrey S. Aronin
|
|
|
40,000
|
|
|
-
|
|
|
-
|
|
|
40,000
|
Antonio Gracias
|
|
|
60,000
|
|
|
175,005
|
|
|
-
|
|
|
235,005
|
R. Mark Graf
|
|
|
55,000
|
|
|
125,010
|
|
|
-
|
|
|
180,010
|
Jack Bech Nielsen(2)
|
|
|
60,000
|
|
|
125,010
|
|
|
-
|
|
|
185,010
|
Juan A. Sabater
|
|
|
55,000
|
|
|
125,010
|
|
|
-
|
|
|
180,010
|
Gary Sender
|
|
|
73,000
|
|
|
229,993
|
|
|
-
|
|
|
302,993
|
Linda Szyper
|
|
|
50,000
|
|
|
125,010
|
|
|
-
|
|
|
175,010
|
Andreas Wicki, Ph.D.(3)
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
-
|
|
|
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Amounts reflect the full grant-date fair value of options granted during 2024 computed in accordance with ASC Topic 718, rather than the amounts paid to or realized by the named individual. We provide information regarding the assumptions used to calculate the value of all option awards in Note 15 to our financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2024.
|
(2)
|
Mr. Nielsen left our Board in June 2024.
|
(3)
|
Because Dr. Wicki does not participate in our Director Compensation Program, he did not receive any compensation for his services on our board of directors in 2024.
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TABLE OF CONTENTS
|
|
|
|
Non-Employee Director
|
|
|
Options Outstanding at
Fiscal Year End (#)
|
Peter Anastasiou
|
|
|
13,107
|
Jeffrey S. Aronin
|
|
|
2,188,288
|
Antonio Gracias
|
|
|
45,584
|
R. Mark Graf
|
|
|
28,152
|
Jack Bech Nielson(1)
|
|
|
-
|
Juan A. Sabater
|
|
|
32,560
|
Gary Sender
|
|
|
59,912
|
Linda Szyper
|
|
|
22,029
|
Andreas Wicki, Ph.D.
|
|
|
-
|
|
|
|
|
(1)
|
In connection with his departure from the Board in June 2024, Mr. Nielsen forfeited any outstanding option awards held by him.
|
TABLE OF CONTENTS
TABLE OF CONTENTS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Name
|
|
|
Grant Date
|
|
|
Number
of
Securities
Underlying
the
Award (#)
|
|
|
Exercise
Price of the
Award
($/Share)
|
|
|
Grant Date Fair
Value of the Award
($)
|
|
|
Percentage Change
|
Kumar Budur
|
|
|
5/1/2024
|
|
|
75,000
|
|
|
30.27
|
|
|
1,539,750
|
|
|
0.32%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
TABLE OF CONTENTS
|
|
|
|
|
|
|
|
|
|
|
|
(a)
|
|
|
(b)
|
|
|
(c)
|
|
Plan Category
|
|
|
Number of securities
to be issued
upon exercise of
outstanding options,
warrants and rights
(#)(1)
|
|
|
Weighted-average
exercise price of
outstanding options
($)
|
|
|
Number of securities
remaining available for future issuance
under equity
compensation plans
(excluding securities reflected in
column (a))
(#)(2)
|
Equity compensation plans approved by stockholders(3)
|
|
|
7,839,343
|
|
|
32.34
|
|
|
10,802,214
|
Equity compensation plans not approved by stockholders
|
|
|
N/A
|
|
|
N/A
|
|
|
N/A
|
Total
|
|
|
7,839,343
|
|
|
32.34
|
|
|
10,802,214
|
|
|
|
|
|
|
|
|
|
|
(1)
|
Includes shares to be issued upon the exercise of outstanding stock options or stock appreciation rights, or upon the vesting of restricted stock unit awards, as of December 31, 2024.
|
(2)
|
Includes shares available for future grants under the 2020 Plan and Employee Stock Purchase Plan ("ESPP"). As of our IPO, no further shares of our common stock have been or will be issued under the Equity Incentive Plan.
|
(3)
|
Consists of our Equity Incentive Plan, 2020 Plan and ESPP. The maximum number of shares of common stock that may be purchased pursuant to our ESPP offering periods in effect as of December 31, 2024 is 16,335.
|
TABLE OF CONTENTS
•
|
each person known by us to beneficially own more than 5% of our common stock;
|
•
|
each of our directors;
|
•
|
each of our named executive officers; and
|
•
|
all of our current executive officers and directors as a group.
|
|
|
|
|
|||
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
|
||||
NAME OF BENEFICIAL OWNER
|
|
|
COMMON STOCK
|
|
|
%
|
5% or Greater Stockholders
|
|
|
|
|
||
Valor IV Pharma Holdings, LLC(1)
|
|
|
6,618,033
|
|
|
11.5%
|
Entities affiliated with FMR LLC (Fidelity)(2)
|
|
|
5,276,825
|
|
|
9.2%
|
Marshman Fund Trust II(3)
|
|
|
6,051,120
|
|
|
10.5%
|
Entities affiliated with BlackRock, Inc.(4)
|
|
|
6,968,097
|
|
|
12.1%
|
The Vanguard Group, Inc.(5)
|
|
|
4,733,609
|
|
|
8.2%
|
Named Executive Officers and Directors:
|
|
|
|
|
||
Jeffrey Dayno(6)
|
|
|
197,379
|
|
|
*
|
Jeffrey Dierks(7)
|
|
|
7,773
|
|
|
*
|
Sandip Kapadia(8)
|
|
|
292,724
|
|
|
*
|
Andrew Serafin(9)
|
|
|
187,696
|
|
|
*
|
Kumar Budur(10)
|
|
|
109,598
|
|
|
*
|
Jeffrey S. Aronin(11)
|
|
|
1,893,137
|
|
|
3.2%
|
Antonio Gracias(12)
|
|
|
6,654,747
|
|
|
11.6%
|
R. Mark Graf(13)
|
|
|
21,816
|
|
|
*
|
Juan A. Sabater(14)
|
|
|
6,644,257
|
|
|
11.6%
|
Gary Sender(15)
|
|
|
48,255
|
|
|
*
|
Linda Szyper(16)
|
|
|
15,693
|
|
|
*
|
Andreas Wicki, Ph.D.(17)
|
|
|
2,147,943
|
|
|
3.7%
|
Peter Anastasiou(18)
|
|
|
3,385
|
|
|
*
|
All current directors and executive officers (13 persons)(19)
|
|
|
14,136,748
|
|
|
23.6%
|
|
|
|
|
|
|
|
*
|
Represents beneficial ownership of less than 1% of outstanding shares of our common stock.
|
(1)
|
Based solely on information contained in a Schedule 13G/A filed on February 12, 2025. As of December 31, 2024, Valor IV Pharma Holdings, LLC was the holder of record of the shares reported in the table above. Valor Management L.P. is the managing member of Valor Equity Capital IV LLC, which is the general partner of Valor Equity Associates IV L.P., which, in turn, is the general partner of each of Valor Equity Partners IV L.P., Valor Equity Partners IV-A L.P. and Valor Equity Partners IV-B L.P. (collectively, the "Valor Funds"). The Valor Funds are the sole members of Valor IV Pharma Holdings, LLC. By virtue of their positions with Valor Management L.P., each of Messrs. Gracias and
|
TABLE OF CONTENTS
(2)
|
Based solely on information contained in a Schedule 13G/A filed with the SEC on February 9, 2024, by FMR LLC in its role as a parent holding company ("FMR") and Abigail P. Johnson. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR, representing 49% of the voting power of FMR. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR. As of December 31, 2023, (i) FMR has sole voting power over 5,275,851 shares, sole dispositive power over 5,276,825 shares, and no shared voting or dispositive power over any shares and (ii) Abigail P. Johnson has sole dispositive power over 5,276,825 shares and no sole voting power, shared voting power or shared dispositive power over any shares. In The address for FMR LLC is 245 Summer Street, Boston, Massachusetts 02210. The address for each of the entities and individuals affiliated with FMR identified above is 245 Summer Street, Boston, Massachusetts 02210.
|
(3)
|
Based solely on information contained in a Schedule 13G/A filed on February 10, 2025. Consists of 6,051,120 shares of common stock held by Marshman Fund Trust II (the "Marshman Shares"). Matthew Gaines, Lisa Aronin and Greg Aronin, serve as the trustees of Marshman Fund Trust II and as a result each may be deemed to beneficially own the Marshman Shares. Each of the trustees disclaims any such beneficial ownership of the Marshman Shares. The address for Marshman Fund Trust II is 330 N. Wabash Ave, Suite 3500, Chicago, IL 60611.
|
(4)
|
Based solely on a Schedule 13G/A filed with the SEC on February 5, 2025, reporting the beneficial ownership of Blackrock, Inc. in its role as a parent holding company ("Blackrock"). As of December 31, 2024, Blackrock has sole voting power over 6,767,563 shares, sole dispositive power over 6,968,097shares, and no shared voting or dispositive power over any shares. The address for each of the entities affiliated with Blackrock is 50 Hudson Yards, New York, NY 10001.
|
(5)
|
Based solely on a Schedule 13G/A filed with the SEC on January 30, 2025, reporting the beneficial ownership of The Vanguard Group, Inc. ("Vanguard"). As of December 31, 2024, Vanguard has shared voting power over 73,029 shares, sole dispositive power over 4,616,923 shares, shared dispositive power over 116,686 shares and no sole voting power over any shares. The address for Vanguard is 100 Vanguard Blvd. Malvern, PA 19355.
|
(6)
|
Includes 191,446 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(7)
|
Represents 7,773 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(8)
|
Includes 243,203 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(9)
|
Includes 186,061 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(10)
|
Includes 108,593 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(11)
|
Includes 1,641,215 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(12)
|
Represents 6,618,033 shares of common stock as described in footnote 1 and 36,714 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(13)
|
Represents 21,816 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(14)
|
Represents 6,618,033 shares of common stock as described in footnote 1 and 26,224 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(15)
|
Represents 48,255 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(16)
|
Represents 15,693 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(17)
|
Based on information contained in a Schedule 13G/A filed on February 14, 2023 and other information known to the Company. Consists of 2,147,943 shares of common stock held by HBM Healthcare Investments (Cayman) Ltd. Voting and investment power over the shares of the Company held by HBM Healthcare Investments (Cayman) Ltd. (the "HBM Shares") is exercised by the board of directors of HBM Healthcare Investments (Cayman) Ltd. (the "HBM Board"). The HBM Board consists of Dr. Wicki, a member of our board of directors, Jean-Marc LeSieur, Richard H. Coles, Sophia Harris, Mark Kronenfeld, M.D. and Richard Paul Woodhouse, none of whom has individual voting or investment power with respect to the HBM Shares. The address for Dr. Wicki is Bundesplatz 1, CH-6301 Zug, Switzerland. The address for HBM Healthcare Investments (Cayman) Ltd. is Governor's Square, Suite 4-212-2, 23 Lime Tree Bay Avenue, West Bay, Grand Cayman, Cayman Islands.
|
(18)
|
Represents 3,385 shares of common stock issuable upon settlement of options which have vested or will vest within 60 days of March 17, 2025.
|
(19)
|
The common stock reported herein consists of (i) 11,606,370 shares of common stock beneficially owned by our current executive officers and directors and (ii) 2,530,378 shares of common stock issuable upon settlement of options which our current executive officers and directors have the right to acquire within 60 days of March 17, 2025. For the purposes of this calculation, the Valor Shares for which each of Messrs. Gracias and Sabater may be deemed beneficial owners are only counted once.
|
TABLE OF CONTENTS
•
|
the amounts involved exceeded or will exceed $120,000; and
|
•
|
any of our directors, nominees for director, executive officers or holders of more than 5% of our outstanding capital stock, or any immediate family member of, or person sharing the household with, any of these individuals or entities, had or will have a direct or indirect material interest.
|
•
|
any breach of the director's duty of loyalty to us or to our stockholders;
|
•
|
acts or omissions not in good faith or that involve intentional misconduct of a knowing violation of law;
|
•
|
unlawful payment of dividends or unlawful stock repurchases or redemptions; and
|
•
|
any transaction from which the director derived an improper personal benefit.
|
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TABLE OF CONTENTS
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TABLE OF CONTENTS