Material Agreement (Form 8-K)

Zura Bio Limited (the "Company") entered into share surrender and warrant agreements (the "Agreements") with entities affiliated with Venrock Healthcare Capital Partners (collectively, "Venrock") on April 16, 2025 and AI Biotechnology, LLC ("AI Biotechnology" and, together with Venrock, the "Shareholders") on April 17, 2025, pursuant to which (i) Venrock and AI Biotechnology will surrender an aggregate of 3.5 million and 3.0 million shares, respectively, of the Company's Class A ordinary shares, par value $0.0001 per share (the "Ordinary Shares"), owned by the Shareholders, for no consideration, which will be immediately cancelled and retired, upon surrender; and (2) the Company will issue pre-funded warrants (the "Warrants") to Venrock and AI Biotechnology to purchase an aggregate of 3.5 million and 3.0 million Ordinary Shares, respectively, with an exercise price of $0.001 per share and no expiration date. The Warrants will be exercisable immediately and have substantially identical terms to the form of warrant previously filed on April 22, 2024 as Exhibit 4.1 to the Company's Current Report on Form 8-K (File No. 001-40598). A holder of the Warrants (together with its affiliates and other attribution parties) may not exercise any portion of a Warrant to the extent that immediately prior to or after giving effect to such exercise the holder would beneficially own more than 9.99% of the Company's outstanding common shares immediately after exercise, which percentage may be increased or decreased to any other percentage specified not in excess of 9.99% at the holder's election upon 61 days' notice to the Company subject to the terms of the Warrants. Immediately following the share surrender and issuance of the Warrants, the total number of the Company's outstanding Class A ordinary shares and pre-funded warrants are expected to be 61,874,998 and 30,384,348, respectively.

The descriptions of the Agreements and the Warrants are not complete and are qualified in their entirety by reference to the Agreements and the form of Warrant, which are filed as Exhibits 10.1, 10.2 and 4.1, respectively, to this Current Report on Form 8-K and incorporated herein by reference.

The information contained in Item 1.01, above, is hereby incorporated by reference. The issuance of the Warrants will be made in reliance upon an exemption from registration pursuant to Section 3(a)(9) of the Securities Act of 1933, as amended.