Proxy Statement (Form DEF 14A)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

PERSPECTIVE THERAPEUTICS, INC.

(Name of Registrant as Specified in its Charter)

(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

April 16, 2026

Dear Stockholder:

You are cordially invited to attend the 2026 Annual Meeting of Stockholders, and any adjournment, postponement or other delay thereof (the "Annual Meeting"), of Perspective Therapeutics, Inc., a Delaware corporation ("Perspective," the "Company," "we" or "us"), which will be held at the Sheraton Grand Chicago Riverwalk, 301 E North Water Street, Chicago, IL 60611 at 9:00 a.m. Central Time on Wednesday, May 27, 2026, for the following purposes:

The Board unanimously recommends that you vote "FOR ALL" on the Election Proposal, "FOR" the Auditor Ratification Proposal and "1 YEAR" for the Say on Frequency Proposal.

The enclosed Notice of Annual Meeting and Proxy Statement describes the formal business to be transacted at the Annual Meeting and information regarding voting and certain other matters. This Notice of Annual Meeting, Proxy Statement and accompanying proxy card are being mailed on or prior to April 16, 2026, to stockholders of record on April 2, 2026.

As we have done in the past, this year, in accordance with SEC rules, we are using the Internet as our primary means of furnishing proxy materials to stockholders. Consequently, most stockholders will not receive paper copies of our proxy materials. We will instead send these stockholders a notice with instructions for accessing the proxy materials and voting via the Internet. The notice also provides information on how stockholders may obtain paper copies of our proxy materials if they so choose. We believe this procedure makes the proxy distribution process more efficient and less costly and helps in conserving natural resources.

Whether or not you expect to attend the Annual Meeting in person, we urge you to vote your shares of our common stock as soon as possible. For security purposes, if you wish to attend the Annual Meeting in person, you will need to pre-register by 5:00 p.m. Pacific Time on May 13, 2026. You may vote prior to the Annual Meeting via the Internet, by telephone or, if you receive a paper proxy card in the mail, by mailing the completed proxy card. Voting by any of these methods will ensure your representation at the meeting and will help ensure the presence of a quorum at the meeting. If you do attend the Annual Meeting, you may change your vote by voting personally on each matter brought before the meeting. If you hold your shares of our common stock in "street name" through a broker, bank or other nominee, you should instruct your broker, bank or other nominee how to vote your shares of our common stock in accordance with the voting instruction form that you will receive from your broker, bank or other nominee.

Your vote is important. Whether or not you are able to attend the Annual Meeting in person, it is important that your shares be represented at the Annual Meeting. Accordingly, we ask that you please vote over the Internet or by telephone at your earliest convenience, or, if you receive a proxy card and a voting instruction form by mail, that you complete, sign and date the proxy card or voting information form and return it in the enclosed envelope (to which no postage need be affixed if mailed in the United States) as soon as possible. If you do attend the Annual Meeting, you may change your vote by voting personally on each matter brought before the meeting.

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We look forward to seeing you at the Annual Meeting.

Sincerely,

/s/ Johan (Thijs) Spoor

Johan (Thijs) Spoor

Chief Executive Officer

Perspective Therapeutics, Inc.

2401 Elliott Avenue, Suite 320

Seattle, WA 98121

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PERSPECTIVE THERAPEUTICS, INC.

NOTICE OF 2026 ANNUAL MEETING

OF STOCKHOLDERS

ITEMS OF BUSINESS

RECOMMENDATIONS

The Board of Directors recommends that you vote "FOR ALL" for the election of each nominee for the Board of Directors in Proposal 1, "FOR" Proposal 2 and "1 YEAR" for Proposal 3.

ADJOURNMENTS AND POSTPONEMENTS

Any action on the items of business described above may be considered at the Annual Meeting at the time and on the date specified above or at any time and date to which the Annual Meeting may be properly adjourned or postponed.

RECORD DATE

You may vote at the Annual Meeting if you were a stockholder of record of our common stock at the close of business on April 2, 2026. If your shares are held through a broker, bank or other nominee, that organization is considered the record holder for purposes of voting at the Annual Meeting and will provide you with instructions on how you can direct that organization to vote your shares.

VOTING

Your vote is very important. Whether or not you plan to attend the Annual Meeting, we encourage you to read the accompanying Proxy Statement and vote as soon as possible. For specific instructions on how to vote your shares of our common stock, please refer to the instructions in the accompanying Notice of Internet Availability of Proxy Materials and the section entitled "General Information About the Annual Meeting and Voting" beginning on page 2 of the accompanying Proxy Statement.

ADMISSION

For security purposes, you will need to pre-register by 5:00 p.m. Pacific Time on May 13, 2026 if you wish to attend the Annual Meeting in person. Specific instructions on pre-registration can be found in the section entitled "General Information About the Annual Meeting and Voting" beginning on page 2 of the accompanying Proxy Statement. In addition to pre-registering, if your shares of our common stock are held through a broker, bank or other nominee and you wish to attend the Annual Meeting, you must obtain a legal proxy from that organization confirming your

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beneficial ownership of the shares as of the record date and bring it to the Annual Meeting. Cameras and recording devices and other electronic equipment will not be permitted at the Annual Meeting.

This Notice of Annual Meeting, Proxy Statement, and accompanying proxy card

are being mailed on or prior to April 16, 2026.

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON MAY 27, 2026:

Under rules adopted by the Securities and Exchange Commission (the "SEC"), we are providing access to our 2026 Annual Meeting materials, which include the accompanying Proxy Statement, a form of proxy card and our Annual Report on Form 10-K for the year ended December 31, 2025, over the Internet in lieu of mailing printed copies at www.proxyvote.com. We will begin mailing a "Notice of Internet Availability of Proxy Materials" (which is different than this Notice of Annual Meeting of Stockholders) to our stockholders on or prior to April 16, 2026. The Notice of Internet Availability of Proxy Materials will contain instructions on how to access and review the Annual Meeting materials and vote online. The Notice of Internet Availability of Proxy Materials will also contain instructions on how you can request a printed copy of the Annual Meeting materials, including a proxy card if you are a record holder or a voting instruction form if you are a beneficial owner.

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TABLE OF CONTENTS

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PERSPECTIVE THERAPEUTICS, INC.

2401 Elliott Avenue, Suite 320

Seattle, WA 98121

PROXY STATEMENT

Annual Meeting of Stockholders

May 27, 2026

We are providing these proxy materials in connection with the solicitation by the Board of Directors (the "Board") of Perspective Therapeutics, Inc., a Delaware corporation ("Perspective," the "Company," "we" or "us"), of proxies to be voted at the Annual Meeting of Stockholders to be held at the Sheraton Grand Chicago Riverwalk, 301 E North Water Street, Chicago, IL 60611 at 9:00 a.m. Central Time on Wednesday, May 27, 2026 (the "Annual Meeting"), and at any adjournment or postponement of the Annual Meeting. These proxy materials will be mailed on or prior to April 16, 2026, to stockholders entitled to vote at the Annual Meeting. This proxy is solicited on behalf of the Board.

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GENERAL INFORMATION ABOUT THE ANNUAL MEETING AND VOTING

The following questions and answers address briefly some questions you may have regarding the Annual Meeting. These questions and answers may not address all questions that may be important to you as a stockholder of the Company. Please refer to the more detailed information contained elsewhere in this Proxy Statement.

Why am I receiving these materials?

You are receiving this Proxy Statement from us because you were the stockholder of record or beneficial owner of shares of our common stock at the close of business on the record date of April 2, 2026, (the "Record Date") for the Annual Meeting. This Proxy Statement contains important information about the Annual Meeting and the items of business to be transacted at the Annual Meeting. You are strongly encouraged to read this Proxy Statement and our Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 16, 2026 (the "Annual Report on Form 10-K"), which includes information that you may find useful in determining how to vote.

At the Annual Meeting, stockholders will be asked to consider and cast a vote on three proposals described in the Notice of Annual Meeting: the Election Proposal, the Auditor Ratification Proposal and the Say on Frequency Proposal. The Board does not know of any matters to be brought before the Annual Meeting other than as set forth in the Notice of Annual Meeting. If any other business is properly presented at the Annual Meeting, the persons named in the enclosed form of proxy or their substitutes will vote in their discretion on such matters.

Who is entitled to attend and vote at the Annual Meeting?

Stockholders as of the Record Date are entitled to attend and to vote at the Annual Meeting. If your shares are held through a broker, bank or other nominee, that organization is considered the record holder for purposes of voting at the Annual Meeting and will provide you with instructions on how to direct that organization to vote your shares.

How many shares of common stock are outstanding?

On the Record Date, 114,017,755 shares of our common stock were issued and outstanding. Each share of our common stock outstanding on the Record Date is entitled to one vote on each item brought before the stockholders at the Annual Meeting.

How many shares of common stock must be present or represented to conduct business at the Annual Meeting?

The presence, in person or by proxy, of a majority of the voting power of all shares of our common stock outstanding on the Record Date is necessary to constitute a quorum at the Annual Meeting. Abstentions and broker non-votes will be counted as present for purposes of determining a quorum at the Annual Meeting.

What shares can I vote at the Annual Meeting?

You may vote all of the shares you owned as of the Record Date, including shares held directly in your name as the stockholder of record and all shares held for you as the beneficial owner through a broker, bank or other nominee.

What is the difference between holding shares of common stock as a stockholder of record and as a beneficial owner?

Most of our stockholders hold their shares through a broker, bank or other nominee rather than directly in their own name. As summarized below, there are some distinctions between shares held of record and those beneficially owned.

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Stockholders of Record. If your shares are registered directly in your name with our transfer agent, Computershare Trust Company, N.A. ("Computershare"), you are considered, with respect to those shares, the stockholder of record, and we are sending our Notice of Internet Availability for Proxy Materials, which contains instructions on how to access and review the Annual Meeting materials and vote online. The Notice of Internet Availability for Proxy Materials (the "Notice") also contains instructions on how you can request a printed copy of the Annual Meeting materials. As the stockholder of record, you have the right to vote in person or direct a proxyholder to vote your shares on your behalf at the Annual Meeting by signing and dating the enclosed proxy card and returning it to us in the enclosed postage-paid return envelope, or by following the procedures for voting over the Internet or by telephone.

Beneficial Owner. If your shares are held by a broker, bank or other nominee, you are considered the beneficial owner of those shares, and they are considered to be held in "street name" for your account. That organization will send you separate instructions describing the procedure for voting your shares. Please follow the directions you are given carefully so that your vote is counted. As a beneficial owner, you may also vote in person at the Annual Meeting, but only after you obtain and present a legal proxy from your broker, bank or other nominee confirming your beneficial ownership of the shares as of the Record Date giving you the right to vote your shares at the Annual Meeting.

How can I vote my shares without attending the Annual Meeting?

Whether you hold shares directly as the stockholder of record or as a beneficial owner, you may direct how your shares are voted without attending the Annual Meeting by voting on the Internet, by phone or by proxy card. If you provide specific instructions regarding items of business to be voted on at the Annual Meeting, your shares will be voted as you instruct on those items. When you sign and return the proxy card, you appoint Johan (Thijs) Spoor and Joel Sendek, and each of them individually, as your representatives at the meeting. Johan (Thijs) Spoor and Joel Sendek will vote your shares at the meeting as you have instructed them. This way your shares will be voted regardless of whether you attend the Annual Meeting. Even if you plan to attend the meeting, please complete, sign and return the enclosed proxy card in advance of the meeting in case your plans change. Returning the proxy card will not affect your right to attend or vote at the Annual Meeting.

If you sign your proxy card with no further instructions, or if you electronically transmit your proxy card but do not direct your vote on particular items, your shares will be voted in accordance with the Board's recommendation on those items. If you hold your shares in "street name" as a beneficial owner and you do not instruct your broker, bank or other nominee how to vote your shares, your broker, bank or other nominee will only be able to vote your shares with respect to the routine matter of the Auditor Ratification Proposal. Please see "What is a broker non-vote?" below.

What proposals will be voted on at the Annual Meeting?

Three proposals are scheduled to be voted on at the Annual Meeting. The proposals are:

What happens if additional matters are presented at the Annual Meeting?

The only items of business that the Board intends to present at the Annual Meeting are set forth in this Proxy Statement. As of the date of this Proxy Statement, no stockholder has advised us of the intent to present any other matter, and we are not aware of any other matters to be presented at the Annual Meeting.

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How can I attend and vote my shares in person at the Annual Meeting?

To attend the Annual Meeting, you must have been a stockholder as of the Record Date or be the legal proxy holder or qualified representative of such a stockholder, and you must pre-register for the Annual Meeting by 5:00 p.m. Pacific Time on May 13, 2026. To pre-register for the Annual Meeting, go to www.proxyvote.com and enter your 16-digit control number, which can be found on your Notice, proxy card or the instructions that accompany your proxy materials. Please note that you will need to pre-register in order to attend the Annual Meeting whether you vote before or at the meeting, and regardless of whether you are a registered or beneficial stockholder.

In addition to the pre-registration requirements, whether you hold shares in your name as the stockholder of record or beneficially own shares held in "street name," you should be prepared to present a valid, government-issued photo identification for admittance to the Annual Meeting. If you are a stockholder of record, you should also be prepared to present your proxy card. If you are a "street name" holder, you will need to obtain a legal proxy from your broker, bank or other nominee confirming your beneficial ownership of the shares as of the Record Date giving you the right to vote your shares at the Annual Meeting, a copy of the voting instruction form provided by your broker, bank or other nominee, or other similar evidence of ownership for admittance to the Annual Meeting. If you are a "street name" holder, you may not vote at the Annual Meeting unless you have obtained a legal proxy from your broker, bank or other nominee.

The Annual Meeting will begin promptly on Wednesday, May 27, 2026 at 9:00 a.m. Central Time at the Sheraton Grand Chicago Riverwalk, 301 E North Water Street, Chicago, IL 60611. Check-in will begin at 8:30 a.m. Central Time.

Even if you plan to attend the Annual Meeting, we recommend that you also vote by Internet, telephone or sign and date the enclosed proxy card or voting instruction form and return it promptly to ensure that your vote will be counted if you later decide not to, or are unable to, attend the Annual Meeting.

Can I change my vote or revoke my proxy?

You may change your vote or revoke your proxy at any time prior to the vote at the Annual Meeting. If you are the stockholder of record, you may change your vote by (i) granting a new proxy bearing a later date, which automatically revokes your earlier proxy, (ii) providing a written notice of revocation to our Corporate Secretary at our principal executive offices prior to the Annual Meeting, or (iii) attending the Annual Meeting and voting in person. However, attendance at the Annual Meeting but not voting in person will not cause your previously granted proxy to be revoked unless you specifically so request. If you are a beneficial owner, you may change your vote by (i) submitting a new voting instruction form to your broker, bank or other nominee, or (ii) if you have obtained a legal proxy from your broker, bank or other nominee giving you the right to vote your shares, by attending the Annual Meeting and voting in person.

What is a "broker non-vote"?

A broker, bank or other nominee holding your shares in "street name" must vote those shares according to any specific instructions it receives from you. In the absence of such instructions, your broker does not have discretion to vote your shares on any proposal that is considered to be "non-discretionary," and may, but is not required to, vote your shares on any "discretionary" proposal. Proposal 1, the Election Proposal, and Proposal 3, the Say on Frequency Proposal, are non-discretionary proposals. Proposal 2, the Auditor Ratification Proposal, is a discretionary proposal. If your broker, bank or other nominee does not vote your shares at the Annual Meeting on a matter, it gives rise to what is called a "broker non-vote."

How are "broker non-votes" counted?

Under the rules of the New York Stock Exchange (the "NYSE") that govern most domestic stock brokerage firms, member firms that hold shares in "street name" for beneficial owners may, to the extent that such beneficial owners do not furnish voting instructions with respect to any or all proposals submitted for stockholder action, vote in their discretion upon proposals which are considered "discretionary" proposals under the rules of the NYSE. These votes by brokerage firms are considered as votes cast in determining the outcome of any discretionary proposal. Member brokerage firms that have received no instructions from their clients as to "non-discretionary" proposals do

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not have discretion to vote on these proposals. If the brokerage firm returns a proxy card without voting on a non-discretionary proposal because it received no instructions, this is referred to as a "broker non-vote" on the proposal. "Broker non-votes" will be considered in determining whether a quorum exists at the Annual Meeting.

In summary, if you do not complete a voting instruction form, your broker, bank or other nominee may either:

We encourage you to provide instructions to your broker, bank or other nominee by voting your proxy. This action ensures that your shares will be voted in accordance with your wishes at the Annual Meeting.

How many votes are required to approve the proposals?

Proposal 1

You may vote "FOR ALL," "WITHHOLD ALL," or "FOR ALL EXCEPT" certain nominees for Proposal 1 (the Election Proposal). The vote with respect to the election of directors (Proposal 1) is governed by Delaware law and the Company's bylaws and is a plurality of the votes cast, provided a quorum is present. If you withhold authority to vote for the election of directors, your shares will not be voted with respect to the director or directors identified. Broker non-votes and votes withheld will have no effect on the election of directors. The six persons receiving the highest number of affirmative votes will be elected as directors of the Company.

Proposal 2

You may vote either "FOR," "AGAINST," or "ABSTAIN" on Proposal 2 (the Auditor Ratification Proposal). The vote required to approve Proposal 2 is governed by Delaware law and the Company's bylaws and is the affirmative vote of a majority in voting power of shares of common stock present in person or represented by proxy and entitled to vote thereon. We do not anticipate broker non-votes in connection with Proposal 2 because brokers, banks, trustees and other nominees will have discretion to vote your shares on Proposal 2 under NYSE rules without specific instructions from the beneficial owners of such shares. Abstentions will have the same effect as voting against Proposal 2.

Because your vote on Proposal 2 is advisory, it will not be binding on the Board or the Company. However, the Board and the Audit Committee will consider the outcome of the advisory vote when making future decisions regarding the selection of our independent registered public accounting firm.

Proposal 3

You may vote "1 YEAR", "2 YEARS", "3 YEARS" or "ABSTAIN" on Proposal 3 (the Say on Frequency Proposal). The vote required to approve Proposal 3 is governed by Delaware law and the Company's bylaws and is the plurality of the votes cast. The Company will consider the option of every one year, two years or three years that receives the highest number of votes cast to be the frequency recommended by stockholders for such proposal. Abstentions and broker non-votes will have no effect on Proposal 3.

If you sign and submit your proxy card without voting instructions, your shares will be voted "FOR ALL" director nominees in Proposal 1, "FOR" Proposal 2 and "1 YEAR" for Proposal 3.

What happens if the Annual Meeting is adjourned?

If the Annual Meeting is adjourned until another time, no additional notice will be given regarding the time or location that the Annual Meeting will be continued, if this information is announced at the time of the adjournment, unless the adjournment is for more than 30 days, in which case a notice of the time and location will be given to each stockholder of record entitled to vote at the Annual Meeting. Any items of business that might have been properly transacted at the Annual Meeting may be transacted at any adjournment.

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Who will serve as inspector of elections?

The General Counsel and Corporate Secretary of the Company, Chris Nenno, will tabulate the votes cast at the Annual Meeting in combination with the votes cast prior to the Annual Meeting and act as the Inspector of Elections at the Annual Meeting.

Will I be receiving printed copies of the 2026 Annual Meeting materials?

You will not receive printed copies unless you request them by following the instructions in the Notice of Internet Availability of Proxy Materials (the "Notice") that you will receive in the mail. The Notice is different than the Notice of Annual Meeting of Stockholders that accompanies this Proxy Statement. We will begin mailing the Notice to stockholders on or prior to April 16, 2026.

Under rules adopted by the SEC, we are providing access to our Annual Meeting materials, which include this Proxy Statement and the Annual Report on Form 10-K, over the Internet in lieu of mailing printed copies. The Notice will contain instructions on how to access and review the Annual Meeting materials and vote online. This electronic access process is designed to expedite stockholders' receipt of materials, lower the cost of the Annual Meeting and help conserve natural resources. The Company encourages you to take advantage of the availability of the proxy materials on the Internet.

The Notice also will contain instructions on how you can request, at no cost, a printed copy of the Annual Meeting materials, including a proxy card if you are a record holder or a voting instruction form if you are a beneficial owner. By following the instructions in the Notice, you may request to receive, at no cost, a copy via e-mail of the Annual Meeting materials or future proxy solicitations. Your request to receive materials via e-mail will remain in effect until you terminate it.

Can I mark my votes on the Notice and send it back to the Company or my broker?

No. The Notice is not a ballot or a proxy card. You cannot use it to vote your shares. If you mark your vote on the Notice and send it back to the Company or your broker, bank or other nominee, your vote will not count.

How can I get electronic access to the Annual Meeting materials?

The Notice will provide you with instructions regarding how to view the Annual Meeting materials on the Internet.

This Proxy Statement and the Annual Report on Form 10-K are also available without charge on the Company's website at www.perspectivetherapeutics.com and the SEC's website at www.sec.gov. By referring to our website, we do not incorporate the website or any portion of the website by reference into this Proxy Statement.

The Notice will also contain instructions on how you can elect to receive future proxy materials electronically by e-mail. Choosing to receive future proxy materials by e-mail will save the Company the cost of printing and mailing documents to you and will reduce the impact of the Company's Annual Meetings on the environment. If you choose to receive future proxy materials by e-mail, you will receive an e-mail message next year with instructions containing a link to those materials and a link to the proxy voting website. Your election to receive proxy materials by e-mail will remain in effect until you terminate it.

Where can I find the voting results of the Annual Meeting?

We intend to announce preliminary voting results at the Annual Meeting and to publish the final voting results in a Current Report on Form 8-K filed with the SEC within four business days following the Annual Meeting.

What is the deadline for submitting proposals for consideration at the next Annual Meeting of stockholders or to nominate individuals to serve as directors?

As a stockholder, you may be entitled to present proposals for action at a future Annual Meeting of stockholders, including director nominations. Please refer to the section entitled "Stockholder Proposals and Director Nominations" in this Proxy Statement.

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How does the Board recommend that I vote?

The Board recommends that you vote "FOR ALL" for the election of each nominee for the Board in Proposal 1, "FOR" Proposal 2 and "1 YEAR" for Proposal 3.

How do I vote my shares without attending the Annual Meeting?

Stockholders of record can vote as follows:

If your shares are held in "street name" through a broker, bank or other nominee, that organization will send you separate instructions describing the procedure for voting your shares. Please follow the directions you are given carefully so your vote is counted.

If you need assistance in voting by telephone or over the Internet or completing your proxy card or have questions regarding the meeting, please contact Perspective Therapeutics, Inc., Attn: Corporate Secretary, 2401 Elliott Avenue, Suite 320, Seattle, WA 98121, telephone number (206) 676-0900.

May stockholders ask questions at the Annual Meeting?

Yes. Representatives of the Company will answer a limited number of stockholders' questions of general interest at the end of the Annual Meeting. In order to give a greater number of stockholders an opportunity to ask questions, individuals or groups will be allowed to ask only one question, and no repetitive or follow-up questions will be permitted.

What does it mean if I receive more than one proxy card?

It generally means you hold shares registered in more than one account. To ensure that all your shares are voted, sign and return each proxy card.

May I change my vote?

Yes. If you vote by mail, Internet, or telephone, you may later change your vote and revoke your earlier proxy by:

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Nominees

The Board currently consists of six members. The Board oversees our business affairs and monitors the performance of management. In accordance with basic principles of corporate governance, the Board does not involve itself in day-to-day operations. The directors keep themselves informed through discussions with the Chairperson, key executive officers, and our principal external advisers (legal counsel, auditors, and other professionals), by reading reports and other materials that are sent to them and by participating in Board and committee meetings.

The Board, on the recommendation of the Board's Nominations and Corporate Governance Committee (the "Nominations Committee"), has nominated the following six existing members of the Board for re-election to the Board at the Annual Meeting: Lori A. Woods (Chairperson), Heidi Henson, Maya Martinez-Davis, Frank Morich, M.D., Ph.D., Johan (Thijs) Spoor and Robert Froman Williamson, III. Maya Martinez-Davis was recommended by an independent third-party search firm engaged by the Company. If elected as a director at the Annual Meeting, each of the nominees would serve a term expiring at the 2027 Annual Meeting of Stockholders and until his or her successor has been elected and qualified. There are no family relationships among our directors, nominees for director or our executive officers.

Each of the nominees has consented to serve as a director if elected. If any of the nominees should be unavailable to serve for any reason, the Board, upon the recommendation of the Nominations Committee, may designate a substitute nominee or nominees (in which event the persons named on the enclosed proxy card will vote the shares represented by all valid proxy cards for the election of such substitute nominee or nominees), allow the vacancies to remain open until a suitable candidate or candidates are located, or by resolution reduce the size of the Board.

Directors

Set forth below is certain information as of April 2, 2026, regarding our current directors that have been nominated for re-election, including biographical information. Each member of the Board is subject to reelection annually.

Lori A. Woods - Ms. Woods has been a director of the Company since June 4, 2018, and has served as Chairperson of the Board since February 3, 2023. Most recently, Ms. Woods served as Chief Executive Officer of the Company from December 2018 to February 2023. Ms. Woods returned to the Company after previously serving as the Company's Vice President from 2006 to February 2008, at which time she was appointed Acting Chief Operating Officer before her appointment in February 2009 as Chief Operating Officer, a position she held until January 2010. Beginning in February 2016, and continuing until her appointment as Interim CEO on June 4, 2018, Ms. Woods served as a senior consultant to the Company. From February 2016 to June 2018, Ms. Woods was a founder of Medvio, LLC, a medical device consulting company focused on the urology and oncology space. During her time at Medvio she worked with large public and international medical device companies, supporting the approval process and distribution of products in diverse international markets. Further, she worked with various partners to develop proprietary technologies for the colorectal and liver treatment markets. Previously, from January 2002 to July 2006, Ms. Woods served as Chief Executive Officer of Pro-Qura, Inc., a privately held cancer treatment management company focused on the quality delivery of brachytherapy treatments for prostate cancer. She has also served as the Director of Business Development for the Tumor Institute Radiation Oncology Group and the Seattle Prostate Institute ("SPI") in Seattle, WA. SPI was an early innovator in prostate brachytherapy treatments and assisted in the training of more than 2,000 physicians in the use of prostate brachytherapy. Ms. Woods previously served as a board member of the Northwest division of the Juvenile Diabetes Research Foundation, focusing on their digital awareness programs, including their

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website and SEO strategy, and their public relations efforts. Ms. Woods earned a Bachelor of Science degree in Business Administration - Marketing and Communications from Loma Linda University, CA. The Board believes that Ms. Woods' prior experience as the Company's Chief Executive Officer and her extensive experience and credibility in the life sciences industry qualifies her to serve on the Board.

Johan (Thijs) Spoor - Mr. Spoor has been a director of the Company and has served as our Chief Executive Officer since February 5, 2023. Mr. Spoor was appointed as a director in connection with the merger of the Company with Viewpoint Molecular Targeting, Inc. ("Viewpoint"). From February 2022 until February 2023, Mr. Spoor served as a director as well as the President and Chief Executive Officer of Viewpoint. Prior to joining Viewpoint, from October 2019 until June 2021, Mr. Spoor served as the President and CEO of KBP Biosciences, a global, clinical-stage biotechnology company focused on discovering, developing, and commercializing innovative small-molecule therapeutics for the treatment of serious cardiorenal and infectious diseases. While at KBP Biosciences, Mr. Spoor led all operations for major fund-raising and initial public offering ("IPO") readiness, and drove the company's small molecule clinical development programs, including toxicology, clinical pharmacology, Phase 2 studies, and discussions with regulators. Prior to KBP BioSciences, from January 2016 until October 2019, Mr. Spoor served as the President and CEO of AzurRx BioPharma, Inc., where he led its Nasdaq IPO, completion of animal studies, regulatory approvals and multiple Phase 2 studies. Mr. Spoor previously served on the board of directors of Verifi Water, Inc. from 2017 through 2023. From September 2010 until December 2015, Mr. Spoor served as the President and CEO of FluoroPharma Medical, Inc., which he took public. He was previously a Health and Life Sciences strategy consultant to Fortune 500 companies at Oliver Wyman. Mr. Spoor previously worked on Wall Street as an equity research analyst at JP Morgan and Credit Suisse where he covered biotechnology stocks and medical device companies. He started his career with formal training in nuclear pharmacy which led to increasing commercial leadership roles in the imaging business at GE Healthcare (Amersham) in cardiology and oncology. Mr. Spoor holds a Pharmacy degree from the University of Toronto and an MBA from Columbia Business School. The Board believes that Mr. Spoor's experience as our Chief Executive Officer and experience as an established leader with nearly 30 years of combined executive, broad management and capital markets expertise across healthcare and medical device industries qualifies him to serve on the Board.

Heidi Henson - Ms. Henson has been a director of the Company since June 1, 2023. Ms. Henson served as the Chief Financial Officer of Pardes Biosciences, Inc., a publicly traded biopharmaceutical company, from January 2021 until it was acquired in September 2023. Prior to that, she was a financial consultant for the same company from 2020 until her appointment as Chief Financial Officer. From 2019 through July 2020, she was the Chief Financial Officer of Imbria Pharmaceuticals, Inc., a private biopharmaceutical company. From 2018 through 2019, she was the Chief Financial Officer of Respivant Sciences, Inc., a private biopharmaceutical company. From 2014 through 2018, she was the Chief Financial Officer of Kura Oncology, Inc., a publicly traded biopharmaceutical company. From 2012 through 2018, Ms. Henson was the Chief Financial Officer for Wellspring Biosciences LLC and Araxes Pharma LLC (its parent company), a private biopharmaceutical company. Ms. Henson currently serves on the board of directors of PepGen, Inc. (NASDAQ: PEPG) and Lisata Therapeutics, Inc. (NASDAQ: LSTA), both publicly traded, clinical-stage biotechnology companies, and she serves as the chair of both of their audit committees. Ms. Henson holds a Bachelor of Accountancy from the University of San Diego and is a Certified Public Accountant (inactive). The Board believes that Ms. Henson's experience as a financial professional with over 25 years of experience in both public and private companies qualifies her to serve on the Board.

Maya Martinez-Davis - Maya Martinez-Davis has been a director of the Company since September 3, 2025. Since January 2019, Ms. Martinez-Davis has served as President, U.S., of GSK (NYSE: GSK), a global pharmaceuticals company, and she became a member of GSK's executive committee in January 2026. Prior to GSK, Ms. Martinez-Davis held a number of leadership roles at Merck Serono, a global pharmaceuticals company, from 2016 to 2019, including President of Latin America biopharma and Senior Vice President and Head of Global Oncology for Merck Serono's biopharma business. Prior to Merck, Ms. Martinez-Davis worked at Pfizer, Inc. (NYSE: PFE), a global pharmaceuticals company, from 2003 to 2015, in the areas of oncology, vaccines and specialty portfolios. Ms. Martinez-Davis also served on the Board of Directors of Mirati Therapeutics, Inc., a clinical-stage biotechnology company focused on the developed of targeted oncology therapies, from 2018 until its acquisition by Bristol Myers Squibb in January 2024. Ms. Martinez-Davis holds an undergraduate degree from Saint Louis University and a Master's degree in business leadership and marketing from the IE Business Institute in Madrid, Spain. The Board believes Ms. Martinez-Davis's breadth of knowledge and valuable understanding of the pharmaceutical industry based on her experience as a pharmaceutical executive and director qualify her to serve on the Board.

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Frank Morich, M.D., Ph.D. - Dr. Frank Morich has been a director of the Company since February 5, 2023. Dr. Morich was appointed as a director in connection with the merger with Viewpoint, prior to which he served on the board of directors of Viewpoint from February 2021 until February 3, 2023. He has also served on the board of directors of CUE-Biopharma (NASDAQ: CUE), a company working on protein therapeutics with applications in immune-oncology, autoimmunity and potentially antiviral applications, since August 2018, and served as its Chairman from April 2021 until June 2025. Dr. Morich also serves as Executive Chairman of Aphaia Pharma, a clinical-stage biopharmaceutical company working to treat and prevent metabolic disorders such as obesity and diabetes, a position he has held since June 2022. Dr. Morich served on the board of directors for MorphoSys from 2015 to 2021, and for Innate Pharma from 2004 to 2010, both clinical-stage biotechnology companies specializing in antibody development. Prior to focusing on board service, Dr. Morich was Chief Commercial Officer at Takeda Pharmaceuticals, a global pharmaceutical company, from 2011 to 2014, and Executive Vice President of International Operations from 2010 to 2011. From 2008 to 2010, Dr. Morich served as Chief Executive Officer of NOXXON Pharma AG, a clinical-stage drug development company, and, from 2005 to 2007, as Chief Executive Officer and member of the board of directors of Innogenetics N.V., an international in vitro diagnostics company. Prior to that, Dr. Morich held several positions at Bayer, a global pharmaceutical and life sciences company, including as a member of the Board of Management of Bayer AG, Head of Global Product Development, and Head of Research and Development. Dr. Morich holds an M.D. and Ph.D. from the University of Marburg where he specialized in immunology with a focus on monoclonal antibodies. He also served as a military physician before moving to the private sector. The Board believes that Dr. Morich's experience as a biopharmaceutical professional with more than 35 years of industry experience qualifies him to serve on the Board.

Robert Froman Williamson, III - Mr. Williamson has been a director of the Company since February 5, 2023. Mr. Williamson was appointed as a director in connection with the merger with Viewpoint. Since June 2025, Mr. Williamson has served as Chairman and CEO at a private stealth biotechnology company exploring novel mechanisms to cross the blood-brain barrier. From September 2022 until July 2025, Mr. Williamson served in a number of leadership roles at Triumvira Immunologicals, a private cell therapy company, including Acting CEO, President, COO and Director. Since March 2022, he has also served as a senior adviser to SyntheX, a protein interaction and degrader company. From February to September 2022, he was the CBO/CFO of OncoMyx, an oncolytic virus company. From 2020 to 2021, he was CEO of BioTheryX, a protein degradation therapeutics company, raising a $100 million crossover round and preparing the company for an IPO. Prior to that, Mr. Williamson served as CEO of PharmAkea from 2013 to 2019, and of ATXCo in 2019, both oncology and fibrosis companies financed through a partnership with Celgene, until PharmAkea's acquisition by Galecto and ATXCo's acquisition by Blade Therapeutics, both in 2019. Previously, Mr. Williamson was Executive Chairman and founder of Strategic Enzyme Applications, CEO of Arriva Pharmaceuticals, President and COO of Eos Biotechnology, which was sold to Protein Design Labs, and COO of DoubleTwist, Inc. through its acquisition by Merck and Hitachi. Mr. Williamson also serves on the Coulter Oversight Board for the University of Miami, Florida, is a qualified financial expert and has chaired both the Audit Committee and the Compensation Committee of the Board (the "Compensation Committee"). Notably, Mr. Williamson served as an early Director of Pharmasset, Inc., where he helped finance, grow and advance the company into the public markets and through its acquisition by Gilead in 2011 for $11 billion. Earlier, Mr. Williamson was a Partner with The Boston Consulting Group and a Research Assistant for the Federal Reserve Board. Mr. Williamson received a BA in economics from Pomona College and an MBA from Stanford University. The Board believes that Mr. Williamson's active involvement in building biotechnology and related technology companies for over two decades qualifies him to serve on the Board.

Board Leadership Structure

The Board has the flexibility to decide when the positions of Chairperson and CEO should be combined or separated and whether an executive or an independent director should be Chairperson. This approach is designed to allow the Board to choose the leadership structure that will best serve the interests of our stockholders at any particular time. The Board's key duties include oversight of strategy, risk management, and legal and regulatory compliance as well as succession planning relating to the Company's Chief Executive Officer ("CEO").

Since June 2018, the Company has separated the roles of Chairperson and CEO because it believes that a bifurcated leadership structure offers the following benefits:

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Risk Oversight

Management is responsible for the day-to-day management of the risks we face, while the Board, as a whole and through its committees, has responsibility for the oversight of risk management. The Board as a whole exercises its oversight responsibilities with respect to strategic, operational and competitive risks, as well as risks related to crisis management and executive succession issues. The Board has delegated oversight of certain other types of risks to its committees. The Audit Committee oversees our policies and processes relating to our financial statements and financial reporting, risks relating to our capital, credit and liquidity status and risks related to related person transactions. The Compensation Committee oversees risks related to our compensation programs and structure, including our ability to motivate and retain talented executives. The Nominations Committee oversees risks related to our governance structure and succession planning for Board membership.

We believe that the Board leadership structure as discussed above promotes effective oversight of the Company's risk management.

Board Committees and Meetings

During the fiscal year ended December 31, 2025, the Board held six meetings. The Board has a separately designated standing Audit Committee established in accordance with Section 3(a)(58)(A) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), the Compensation Committee and the Nominations Committee.

Audit Committee. The Audit Committee is responsible to the Board for the areas of audit and compliance and (i) oversees the Company's financial reporting process and internal control system, including monitoring the integrity of the financial statements and the independence and performance of the Company's independent auditor, and (ii) supervises the Company's compliance with legal and regulatory requirements. The Audit Committee is also responsible for maintaining complete, objective and open communication between the Board, the Company's independent auditor, financial management, and the internal audit function (if any). On a regular basis, the Chief Financial Officer of the Company or his designee reports to the Board or the Audit Committee on information technology and cybersecurity matters, including key risks, the potential impact of those exposures on the Company's business, financial results, operations and reputation, the programs and steps implemented by management to monitor and mitigate exposures, the Company's information governance and cybersecurity policies and programs, and significant legal/regulatory developments that could materially impact the Company's cybersecurity risk exposure.

The Company's independent auditor reports directly to the Audit Committee. The Audit Committee is solely responsible for appointing or replacing the Company's independent auditor, assuring the auditor's independence and providing oversight and supervision thereof. The Audit Committee determines the compensation of the independent auditor and has established a policy for approval of certain non-audit related engagements awarded to the independent auditor. Such engagements must not impair the independence of the auditor with respect to the Company, as prescribed by the Sarbanes-Oxley Act of 2002; thus, non-audit related engagements must be approved in advance by the Audit Committee. The Audit Committee determines the extent of funding that the Company must provide to the Audit Committee to carry out its duties and has determined that such amounts were sufficient in the fiscal year ended December 31, 2025.

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The current members of the Audit Committee are Ms. Henson (Chair), Mr. Williamson and Dr. Morich, each of whom has been determined to be financially literate and meets the independence standards for members of public company audit committees set forth in SEC rules adopted under the Sarbanes-Oxley Act of 2002 and applicable NYSE American listing standards. The Audit Committee operates under the Audit Committee Charter, which has been approved by the Board. The Board has determined that Ms. Henson is an "audit committee financial expert" as defined under SEC rules. The Board has affirmatively determined that none of the members of the Audit Committee have a material relationship with the Company that would interfere with the exercise of independent judgment and that each of the members of the Audit Committee is "independent" as independence is defined in Section 803B(2) of the NYSE American listing standards and Rule 10A-3 under the Exchange Act.

Compensation Committee. The Compensation Committee is responsible for establishing and reviewing the compensation and employee benefit policies of the Company. The Compensation Committee operates under a charter approved by the Board. The Compensation Committee reviews and recommends to the Board for approval the compensation for the Company's CEO and its other executive officers, including salaries, bonuses and grants of awards under, and administration of, the Company's equity incentive plans. The Compensation Committee, among other things, approves or reviews the employees and other individuals to whom awards will be made under the Company's equity incentive plans, and the time, manner of exercise, vesting and other terms of the awards. The CEO provides input to the Compensation Committee with respect to the individual performance and compensation recommendations for all executive officers (other than himself). Pursuant to its charter, the Compensation Committee has the authority to engage independent compensation consultants and other professionals to assist in the design, formulation, analysis, and implementation of compensation programs for our executive officers.

In fulfilling its responsibilities, the Compensation Committee is entitled to delegate its authority to a subcommittee composed solely of one or more members of the Compensation Committee or the Board as the Compensation Committee may deem appropriate, including to grant awards of equity under the Company's equity incentive plans to persons who are not then subject to Section 16 of the Exchange Act, but only to the extent consistent with and permitted by the Company's certificate of incorporation, bylaws, corporate governance guidelines, the Delaware General Corporation Law and rules of the NYSE American. The Compensation Committee has delegated authority to the CEO to grant awards of equity, subject to the aforementioned limitations and within certain parameters established by the Compensation Committee from time to time.

The current members of the Compensation Committee are Mr. Williamson (Chair), Ms. Henson and Ms. Martinez-Davis. The Board has affirmatively determined that each of the members of the Compensation Committee is "independent" as independence is defined in Section 805(c) of the NYSE American listing standards and Rule 10C-1 under the Exchange Act. Ms. Woods previously served as a non-independent member of the Compensation Committee during early 2025 pursuant to Section 805(b) of the NYSE American listing standards.

Nominations and Corporate Governance Committee. The Nominations Committee identifies and solicits recommendations from management and other members of the Board of individuals qualified to potentially serve as Board members. The Nominations Committee also recommends the director nominees to the Board for election at annual meetings of stockholders. The Nominations Committee oversees the annual review and evaluation of the performance of the Board and its committees and develops and recommends corporate governance guidelines to the Board. In addition, the Nominations Committee examines, evaluates, and monitors the independence of directors for general Board positions as well as for specific committee duties, and evaluates specific qualifications for members serving as audit committee financial experts.

The current members of the Nominations Committee are Dr. Morich (Chair), Ms. Henson and Ms. Martinez-Davis. The Board has affirmatively determined that each of the members of the Nominations Committee is "independent" as independence is defined in Section 803A of the NYSE American listing standards. Ms. Woods previously served as a non-independent member of the Nominations Committee during early 2025 pursuant to Section 804(b) of the NYSE American listing standards.

The Board and its committees may retain outside advisors as they determine necessary to fulfill their responsibilities. All committees report their activities to the full Board. The charters of the Audit Committee, the Compensation Committee and the Nominations Committee are posted on the Company's website: https://perspectivetherapeutics.com/investors/governance-documents.

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In addition, pursuant to the NYSE American listing standards, the independent directors are required to meet at least annually in executive session.

Each current Board member attended at least 75% of the aggregate meetings of the Board and of the committees on which he or she served that were held during the period for which he or she was a Board or committee member in the fiscal year ended December 31, 2025.

The following table summarizes the membership of the Board and each of its committees as of the date of this Proxy Statement, as well as the number of times the Board and each committee met during the fiscal year ended December 31, 2025.

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Report of the Audit Committee of the Board

One of the primary purposes of the Audit Committee is to oversee the accounting and financial reporting processes of the Company on behalf of the Board.

In the performance of its oversight function, the Audit Committee has reviewed and discussed the Company's audited consolidated financial statements for the fiscal year ended December 31, 2025 with management and with Withum Smith+Brown, PC ("Withum"), the Company's independent registered public accounting firm for the fiscal year ended December 31, 2025. In addition, the Audit Committee has discussed with Withum the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (the "PCAOB") and the U.S. Securities and Exchange Commission (the "SEC"). The Audit Committee has also received the written disclosures and the letter from Withum required by the applicable requirements of the PCAOB regarding Withum's communications with the Audit Committee concerning independence, and has discussed with Withum the accounting firm's independence.

Based on the review and discussions referenced above, the Audit Committee recommended to the Board that the Company's audited consolidated financial statements for the fiscal year ended December 31, 2025 be included in the Company's Annual Report on Form 10-K for the year ended December 31, 2025.

The material in this report is not "soliciting material," is not deemed "filed" with the SEC and is not to be incorporated by reference in any of the Company's filings under the Securities Exchange Act of 1934, as amended, or the Securities Act of 1933, as amended, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing, except to the extent the Company specifically incorporates such report by reference therein.

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Nomination Process

The Nominations Committee is the nominating committee of the Board. The Nominations Committee is governed by the Company's Certificate of Incorporation and bylaws with respect to the nominations process. The Nominations Committee is responsible for recommending nominees for nomination by the Board for election to the Board. The Nominations Committee will consider nominations from stockholders, provided that such nominations are received by the Company's Corporate Secretary in accordance with the Certificate of Incorporation, the bylaws, and the date set forth in the prior year's Proxy Statement.

The Nominations Committee will perform the following duties with respect to director nominations: (a) consider the criteria for identifying and recommending individuals who may be nominated for election to the Board; (b) provide a recommendation to the Board of the slate of nominees for election to the Board; (c) as the need arises, make recommendations to fill vacancies and actively seek individuals qualified to become Board members; and (d) consider stockholder nominations for the Board when properly submitted in accordance with the Company's Certificate of Incorporation and bylaws.

The Nominations Committee will consider candidates for the Board who are recommended by its members, other Board members, stockholders and management, as well as those identified by any third-party search firm the Company may retain to assist in identifying and evaluating possible candidates. The Nominations Committee evaluates candidates recommended by stockholders in the same manner that it evaluates other candidates. The Nominations Committee's evaluations will be based upon several criteria, including (among others) candidates' relevant expertise to offer advice and guidance to management, excellence in his or her field, the ability to exercise sound business judgment, a commitment to represent the long-term interests of the Company's stockholders, independence, sufficient time to devote to the affairs of the Company, diversity of background, skills and other factors, the extent to which a candidate would fill a present need or expected future needs on the Board, and personal and professional ethics. Candidates should have reputations, both personal and professional, consistent with the Company's image and reputation.

At a minimum, the majority of directors on the Board should be "independent," not only as that term may be legally defined, but also without the appearance of any conflict in serving as a director. In addition, directors must have time available to devote to Board activities and to enhance their knowledge of the radiopharmaceutical industry. Accordingly, the Nominations Committee seeks to attract and retain highly qualified directors who have sufficient time to attend to their substantial duties and responsibilities to the Company. The Company does not have a formal policy related to consideration of diversity in identifying director nominees. However, in identifying candidates for membership on the Board, the Nominations Committee will take into account all factors it considers appropriate, which may include, among other things, strength of character, mature judgment, career specialization, relevant technical skills, and the extent to which the candidate would fill a present need or expected future needs on the Board.

The Nominations Committee utilizes the following process to identify and evaluate nominees for the Board. In the case of incumbent directors whose terms of office are set to expire, the Nominations Committee will review such directors' overall service to the Company during their term, including the number of meetings attended, level of participation and quality of performance. In the case of new director candidates, the members of the Nominations Committee will be polled for suggestions as to potential candidates that may meet the criteria above, discuss candidates suggested by Company stockholders and may also engage, if deemed appropriate, a professional search firm. The Nominations Committee will then meet to discuss and consider these candidates' qualifications and then choose a candidate to recommend by majority vote. The Company engaged an independent third-party search firm to assist the Nominations Committee and the Board in identifying and evaluating potential Board nominees. In connection with this engagement the search firm recommended Maya Martinez-Davis as a potential Board nominee.

Vote Required

You may vote "FOR ALL," "WITHHOLD ALL," or "FOR ALL EXCEPT" certain nominees for Proposal 1. The vote with respect to the election of directors is governed by Delaware law and the Company's bylaws and is a plurality of the votes cast, provided a quorum is present. If you withhold authority to vote for the election of directors, your shares will not be voted with respect to the director or directors identified. Broker non-votes and withheld votes will have no effect on the election of directors. The six persons receiving the highest number of affirmative votes will be elected as directors of the Company.

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Recommendation of the Board

The Board unanimously recommends that the stockholders vote "FOR ALL" on Proposal 1 to elect Lori A. Woods, Heidi Henson, Maya Martinez-Davis, Frank Morich, M.D., Ph.D., Johan (Thijs) Spoor and Robert Froman Williamson, III as directors for a term expiring at the 2027 Annual Meeting of Stockholders and until their successors have been elected and qualified.

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PROPOSAL 2 - RATIFICATION OF APPOINTMENT OF THE INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Audit Committee has appointed the firm WithumSmith+Brown, PC ("Withum") to serve as our independent registered public accounting firm for the fiscal year ending December 31, 2026 and has directed that such appointment be submitted to our stockholders for ratification at the Annual Meeting. Our organizational documents do not require that our stockholders ratify the selection of our independent registered public accounting firm; however, we are seeking stockholder approval of the selection as a matter of good corporate practice. If our stockholders do not ratify the selection, the Audit Committee will reconsider whether to retain Withum, but still may retain Withum, nonetheless. Even if the selection is ratified, the Audit Committee, in its discretion, may change the appointment at any time during the year if it determines that such a change would be in our best interests. Representatives from Withum are expected to attend the Annual Meeting. The representatives of Withum will have the opportunity to make a statement if they desire to do so, and such representatives are expected to be available to respond to appropriate questions.

Change in our Independent Registered Accounting Firm

During the year ended December 31, 2023, the six months ended December 31, 2022 and the year ended June 20, 2022, Assure CPA, LLC ("Assure") served as our independent registered public accounting firm.

As described in the Company's Current Report on Form 8-K filed with the SEC on April 8, 2024, as a result of the Audit Committee's competitive process to determine the Company's independent registered public accounting firm for the fiscal year ending December 31, 2024, the Audit Committee approved the dismissal of Assure CPA, LLC ("Assure") as the Company's independent registered public accounting firm, effective immediately on April 5, 2024. Also on April 5, 2024, the Audit Committee approved the engagement of Withum to serve as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2024, effective immediately.

The audit reports of Assure on the Company's consolidated financial statements for the fiscal years ended December 31, 2023 and June 30, 2022 and for the six-month transition period ended December 31, 2022 did not contain an adverse opinion or a disclaimer of opinion, nor were they qualified or modified as to uncertainty, audit scope or accounting principles.

During the fiscal years ended December 31, 2023 and June 30, 2022, the six-month transition period ended December 31, 2022, and through April 5, 2024, there were no: (i) disagreements with Assure on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of Assure, would have caused Assure to make reference thereto in its reports on the financial statements of the Company for such years and period, or (ii) reportable events as described under Item 304(a)(1)(v) of Regulation S-K.

We requested that Assure furnish us with a letter addressed to the SEC stating whether it agrees with the above statements. A copy of the letter dated April 8, 2024 is filed as an exhibit to a Current Report on Form 8-K filed with the SEC on April 8, 2024.

During the fiscal years ended December 31, 2023 and June 30, 2022, the six-month transition period ended December 31, 2022 and through April 5, 2024, neither the Company nor anyone on the Company's behalf consulted with Withum regarding any of the matters referred to in Item 304(a)(2)(i) or (ii) of Regulation S-K.

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Audit and Non-Audit Fees

The following table provides aggregate fees billed to the Company for the periods identified below by Withum.

Audit fees include fees for the audit of our annual financial statements, reviews of our quarterly financial statements, related consents for documents filed with the SEC and issuance of comfort letters in connection with equity offerings.

Audit-related fees consist of fees in connection with (i) compliance audits related to grant funding we have received from the National Institutes of Health and (ii) due diligence and other services related to the performance of the audit or review of the Company's financial statements but not otherwise reportable as audit fees.

There were no tax fees or other fees for the periods presented.

As part of its responsibility for oversight of our independent registered public accounting firm, the Audit Committee has established a pre-approval policy for engaging audit and permitted non-audit services provided by our independent registered public accounting firm. In accordance with this policy, each type of audit, audit-related, tax and other permitted service to be provided by the independent auditors is specifically described and each such service, together with a fee level or budgeted amount for such service, is pre-approved by the Audit Committee. The Audit Committee has delegated authority to its Chairperson to pre-approve services (provided such services are not prohibited by applicable law) up to a pre-established aggregate dollar limit. All services pre-approved by the Chairperson of the Audit Committee are presented at the next Audit Committee meeting for review or ratification. All of the services provided by Withum described above were approved or ratified by the Audit Committee.

Vote Required

You may vote either "FOR," "AGAINST," or "ABSTAIN" on Proposal 2. The vote required to approve Proposal 2 is governed by Delaware law and the Company's bylaws and is the affirmative vote of a majority in voting power of shares of common stock present in person or represented by proxy and entitled to vote thereon. We do not anticipate broker non-votes in connection with Proposal 2 because brokers, banks, trustees and other nominees will have discretion to vote your shares on Proposal 2 under NYSE rules without specific instructions from the beneficial owners of such shares. Abstentions will have the same effect as voting against Proposal 2.

Because your vote on Proposal 2 is advisory, it will not be binding on the Board or the Company. However, the Board and the Audit Committee will consider the outcome of the advisory vote when making future decisions regarding the selection of our independent registered public accounting firm.

Recommendation of the Board

The Board unanimously recommends that the stockholders vote "FOR" Proposal 2 to ratify the appointment of WithumSmith+Brown, PC as the independent registered public accounting firm of the Company for the fiscal year ending December 31, 2026.

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Background of the Proposal

In accordance with Section 14A of the Exchange Act and as required by the Dodd-Frank Act, the Board is also asking our stockholders to vote, on a non-binding, advisory basis, on how frequently we should conduct an advisory stockholder vote on the compensation of our named executive officers (sometimes referred to as "say-on-frequency"). The Board believes that an annual advisory vote will enable our stockholders to provide timely, direct input on our executive compensation program as disclosed in our proxy statement each year, and is consistent with our efforts to engage in an ongoing dialogue with our stockholders. Accordingly, we ask that you support a frequency of every one year for future stockholder advisory votes to approve the compensation of our named executive officers.

By voting on this proposal, stockholders may indicate whether they would prefer an advisory vote on the compensation of our named executive officers once every one, two or three years. Because this proposal calls for a non-binding advisory vote, the Board and the Compensation Committee may determine to hold "say-on-pay" votes more or less frequently than the option approved by our stockholders (though no less frequently than once every three years). However, the Board and the Compensation Committee value the opinions of our stockholders and will consider the outcome of the vote when determining the frequency of future "say-on-pay" votes. We will provide a "say-on-frequency" vote at least once every six years, as required by the Dodd-Frank Act.

We are presenting the following proposal, which gives you as a stockholder the opportunity to inform us as to how often you wish the Company to include a "say-on-pay" proposal in our proxy statements. This resolution is required pursuant to Section 14A of the Securities Exchange Act (15 U.S.C. 78n-1). The current frequency of stockholder advisory votes on executive compensation is every three years and, under the current frequency, the next such vote would occur at the fiscal year 2028 annual meeting of stockholders. While the Board intends to carefully consider the stockholder vote resulting from the proposal, the final vote will not be binding on us and is advisory in nature.

"RESOLVED, that the stockholders wish the Company to include an advisory vote on the compensation of the Company's named executive officers pursuant to Section 14A of the Securities Exchange Act every:

After careful consideration, the Board has determined that an advisory vote on executive compensation that occurs every year is the most appropriate for a company such as the Company, and recommends that stockholders vote for a frequency of "1 YEAR" for future advisory stockholder votes on executive compensation. The Board believes that an annual advisory vote will enable our stockholders to provide timely, direct input on our executive compensation program as disclosed in the Company's proxy statement each year, and is consistent with our efforts to engage in an ongoing dialogue with our stockholders. The Compensation Committee, which administers the Company's executive compensation program, values the opinions expressed by our stockholders in these votes, and even though such votes are non-binding, will continue to consider the outcome of these votes in making its decisions on executive compensation.

Stockholders may cast a vote on the frequency of our advisory vote by choosing the option of (i) "1 YEAR", (ii) "2 YEARS", (iii) "3 YEARS" or (iv) by abstaining from voting.

Vote Required

You may vote "1 YEAR", "2 YEARS", "3 YEARS" or "ABSTAIN" on Proposal 3. The vote required to approve Proposal 3 is governed by Delaware law and the Company's bylaws and is the plurality of the votes cast. The Company will consider the option of every one year, two years or three years that receives the highest number of votes

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cast to be the frequency recommended by stockholders for such proposal. Abstentions and broker non-votes will have no effect on Proposal 3.

Recommendation of the Board

The Board unanimously recommends that stockholders vote for the approval, on a non-binding advisory basis, of a frequency of "1 YEAR" on the proposal recommending the frequency of advisory stockholder votes on the compensation of our named executive officers.

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information regarding the beneficial ownership of the Company's common stock as of the Record Date for (a) each person known by the Company to be a beneficial owner of 5% or more of the outstanding common stock of the Company, (b) each named executive officer, director and nominee for director of the Company, and (c) all current directors and executive officers of the Company as a group. As of April 2, 2026, the Company had 114,017,755 shares of common stock outstanding. Except as otherwise indicated below, the address for each listed beneficial owner is c/o Perspective Therapeutics, Inc., 2401 Elliott Avenue, Suite 320, Seattle, WA 98121.

* Less than one percent.

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SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section 16(a) of the Exchange Act requires the Company's directors and executive officers, and persons who beneficially own more than 10% of a registered class of our equity securities, to file with the SEC initial reports of beneficial ownership and reports of changes in beneficial ownership of our common stock. The rules promulgated by the SEC under Section 16(a) of the Exchange Act require those persons to furnish us with copies of all reports filed with the SEC pursuant to Section 16(a). The information in this section is based solely upon a review of Forms 3, Forms 4, and Forms 5 received by us.

Delinquent Section 16(a) Reports

Based on Company records and other information, we believe that all reporting requirements for the year ended December 31, 2025 were complied with by each person who at any time during such year was a director or an executive officer or beneficially owned more than 10% of our common stock.

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EXECUTIVE OFFICERS

The executive officers serving the Company as of April 2, 2026, were as follows:

Company Service History

Mr. Spoor was appointed as CEO and as a director of the Company on February 5, 2023. Dr. Puhlmann was appointed as Chief Medical Officer of the Company on February 5, 2023. Mr. Sendek was appointed as Chief Financial Officer of the Company on September 4, 2025. The Board appoints our officers, and their terms of office are at the discretion of the Board. Mr. Spoor, Dr. Puhlmann and Mr. Sendek have employment agreements.

Professional History

Johan (Thijs) Spoor - Mr. Spoor's biographical information is incorporated by reference to the "Directors" section in the discussion of Proposal 1.

Markus Puhlmann, M.D., MBA - Dr. Puhlmann has served as the Chief Medical Officer of Perspective Therapeutics since February 5, 2023, prior to which he served as the Chief Medical Officer of Viewpoint beginning in October 2022. Dr. Puhlmann is a clinical researcher with over 30 years of combined experience in healthcare and the pharmaceutical industry with leadership positions in oncology drug development for solid and liquid tumor indications involving all phases of clinical development. Before joining Viewpoint, Dr. Puhlmann served as the CD30 Franchise Head of Global Clinical Development at Seagen (NASDAQ: SGEN) from 2019 to 2022, where he built programs to explore the immune modulating properties of antibody-drug conjugates for various oncology and non-oncology indications. Prior to his time at Seagen, Dr. Puhlmann worked at Merck & Co on the clinical development of pembrolizumab from 2015 to 2019. After initiating the pembrolizumab gynecological program, Dr. Puhlmann focused on the expansion of genitourinary indications and developed an extensive trial portfolio. In this capacity, Dr. Puhlmann led and contributed to many successful regulatory filings for pembrolizumab across different indications such as urothelial carcinoma, renal cell carcinoma and cervical cancer. In addition, Dr. Puhlmann led the clinical development program for the collaboration of the partnership between Merck and EISAI. Earlier in his career, he held various positions with increasing responsibilities in clinical development and medical affairs at Schering Plough, Bayer and Amgen. Dr. Puhlmann also spent six years at the Surgery Branch, NCI, NIH, where he researched suicide gene therapy approaches including the effects of cytokines on tumor neovasculature. Dr. Puhlmann trained as a surgeon in the UK and Germany and holds a medical degree from the Ludwig Maximilians University, Munich, Germany as well as an Executive MBA from Georgetown's McDonough School of Business.

Joel Sendek - Mr. Sendek has served as the Company's Chief Financial Officer since September 4, 2025. Mr. Sendek has over 30 years of experience in the life sciences sector, including as a Chief Financial Officer at four life sciences companies and as a senior sell-side research analyst covering the biotechnology sector. Prior to joining the Company, Mr. Sendek was Managing Director and Head of Healthcare Life Sciences Research at Oppenheimer & Co. Inc., a global brokerage and investment bank, from August 2022 to September 2025. Prior to Oppenheimer, he held Chief Financial Officer roles at four companies, including Dewpoint Therapeutics, a private biotechnology company, from January 2021 to July 2022, Sema4, a private health intelligence company, from November 2019 to January 2021, Spero Therapeutics, a publicly traded biopharmaceutical company, from May 2017 to November 2019, and Forward Pharma A/S, a private biopharmaceutical company, from August 2014 to April 2017. Prior to his Chief Financial Officer roles, he served as a Managing Director at Stifel Financial Corp. from January 2012 to July 2014, where he led the firm's healthcare equity research group, and as Managing Director at Lazard from January 2000 to October 2011, where he established and led the firm's healthcare equity research effort. Prior to his career in equity research, Mr. Sendek worked as Senior Director of Corporate Development at Progenics Pharmaceuticals, Inc. and as an investment banking analyst at Goldman, Sachs & Co. Mr. Sendek holds a B.A. in Biochemistry from Rice University.

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There are no agreements or understandings for any officer or director to resign at the request of another person, and none of the officers or directors is acting on behalf of, or will act at the direction of, any other person. There are no family relationships among our executive officers and directors.

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COMPENSATION OF DIRECTORS AND EXECUTIVE OFFICERS

Executive Compensation

Our named executive officers for the fiscal year ended December 31, 2025 were:

The Company's compensation policies and philosophies are designed to align compensation with business objectives and the interests of stockholders, while also enabling the Company to attract, motivate and retain individuals who contribute to its long-term success. The compensation of the Company's named executive officers primarily consists of salary, annual cash incentives tied to pre-defined metrics and equity-based incentive awards. The Company currently provides equity-based incentive awards that are exclusively in the form of stock options, which the Company views as inherently performance-based compensation as economic value is recognized only if the Company's stock price increases, which aligns with stockholder interests. The Company believes that stock options are an appropriate equity vehicle for a clinical-stage pharmaceutical company where achievement of milestones and clinical outcomes can require a long-term cycle of strong execution by the leadership team.

Following the vote on the "Say-on-Pay" proposal at our 2025 Annual Meeting of Stockholders, which received less than 80% support (the "2025 Say on Pay Vote"), the Company, under the leadership of the Chair of the Compensation Committee, engaged with a number of its significant stockholders to discuss the Company's executive compensation program and corporate governance framework. The Company also implemented a number of significant changes to its executive compensation and corporate governance practices such as amending and restating employment agreements with each of the Company's executive officers to, in part, remove certain "single trigger" features that would have applied in the event of a change in control of the Company; adding an additional independent director to the Board; and including additional disclosure regarding the Company's executive compensation program and corporate governance framework in this Proxy Statement. For additional information, see "Stockholder Engagement and Say-on-Pay Feedback," below.

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Summary Compensation Table

The following summary compensation table sets forth information concerning compensation for services rendered in all capacities during the fiscal years ended December 31, 2025 and 2024, earned by or paid to our named executive officers. Salary and other compensation for the named executive officers are set or recommended to the Board by the Compensation Committee.

Narrative to Summary Compensation Table

The Compensation Committee typically reviews and discusses management's proposed compensation decision with the Chief Executive Officer for all executives other than the Chief Executive Officer. Based on those discussions and its discretion, the Compensation Committee then approves the compensation of each executive officer after discussions without members of management present. With respect to the compensation of the Chief Executive Officer, the Compensation Committee makes a recommendation to the full Board, which approves the compensation of the Chief Executive Officer. The Chief Executive Officer is not present during deliberations or voting regarding his compensation.

Annual Base Salary

Annual base salaries are intended to provide a fixed component of compensation to our named executive officers. The Compensation Committee reviews and approves the base salaries of our named executive officers other than our Chief Executive Officer, whose base salary is reviewed and approved by the full Board upon the recommendation of the Compensation Committee. See "Employment Agreements and Separation Agreements - Current Employment Agreements with our Named Executive Officers" below for more information.

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Non-Equity Incentive Plan Compensation

We provide for annual cash incentives that reinforces our pay-for-performance approach. This incentive compensation is a short-term incentive program that rewards achievement. Annual incentive awards are awarded at the sole determination of the Compensation Committee (or, in the case of the Chief Executive Officer, the full Board) based on the actual and measurable performance of the Company based on a set of corporate objectives for the previous year and are paid in the first quarter of the following year.

For the year ended December 31, 2025, our Chief Executive Officer had an opportunity to earn a bonus of 60% of his annual base salary, and each other named executive officer had an opportunity to earn a bonus of 40% of his annual base salary by meeting the target metrics as determined by the Compensation Committee.

For the year ended December 31, 2025, the corporate objectives underlying the Company's annual cash incentive plan consisted of 21 operational objectives with weightings ranging from 1.25% to 10% of the overall bonus opportunity. The objectives covered a variety of metrics, including several related to the Company's clinical programs (including patient enrollment across the Company's clinical programs and cohorts), production capabilities (including validation of suppliers, capacity and capabilities at the Company's manufacturing facilities, and progress on the build-out of the Company's manufacturing network), research and development activities (including generation of intellectual property and first-in-human images for new compounds), financial position (including cash runway), quality (including electronic record keeping) and employee engagement.

Based on its review of the Company's performance against the 2025 corporate objectives, the Compensation Committee (and, with respect to Mr. Spoor, the full Board) determined that the metrics underlying the Company's cash bonus plan for 2025 were achieved at 100%. Accordingly, Mr. Spoor, Mr. Sendek and Dr. Puhlmann received cash bonuses at 100% of target for 2025, with Mr. Sendek's annual cash bonus pro rated based on his start date, all as reflected in the column of the "Summary Compensation Table" above entitled "Non-Equity Incentive Plan Compensation."

Equity-Based Compensation

Stock options are granted to reward individuals for current performance, as an incentive for future performance and to align the long-term interests of our named executive officers with our stockholders. Stock options are granted under the Company's 2020 Equity Incentive Plan, as amended from time to time (the "2020 Equity Incentive Plan").

The Company currently grants equity-based compensation exclusively in the form of stock options. The Compensation Committee believes that stock options are an appropriate vehicle for our equity program because the value ultimately realized by a recipient depends entirely on appreciation in the market price of our common stock after the date of grant. As a result, stock options emphasize pay-for-performance alignment with stockholders, as recipients realize value only if stockholder value is created. The Compensation Committee also believes that stock options are well-suited to our current (pre-revenue) stage of development, as they facilitate long-term retention and motivation while focusing participants on sustained increases in stock price over time. The Compensation Committee periodically reviews the structure of the Company's equity program and may consider alternative equity vehicles in the future based on the Company's evolving business needs, dilution considerations, market practices and stockholder interests.

The Company generally awards stock options to named executive officers at commencement of employment and annually thereafter after taking into consideration the results of a competitive analysis that benchmarks long-term incentive awards granted to executives in comparable positions at peer companies and the current and potential future value of such individuals' outstanding equity awards. The exercise price for each stock option grant is the closing price of our common stock on the date of grant. Each option grant is for a term of 10 years from the date of grant. During 2025, the vesting schedules applicable to option awards to the Company's named executive officers and other employees were as follows: (i) 25% of each "new-hire" award vests on the first anniversary of the grant date, and the remaining shares subject to such award vest in 36 equal monthly installments thereafter, and (ii) grants to existing named executive officers and other employees vest in 48 equal monthly installments beginning on the date that is one month after the grant date.

During the year ended December 31, 2025, Mr. Spoor was granted 650,000 options, Dr. Puhlmann was granted 165,000 options, Mr. Graham was granted a "new-hire" grant of 400,000 options and did not receive an additional

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annual equity award, and Mr. Sendek received a "new-hire" grant of 600,000 options and did not receive an additional annual equity award. In connection with Mr. Graham's separation from the Company, all of the 400,000 stock options he received upon joining the Company were forfeited.

During the years ended December 31, 2024 and 2025, no options were repriced or otherwise materially modified.

401(k) Plan

The Company has a 401(k) plan that covers all eligible full-time employees of the Company. Contributions to the 401(k) plan are made by participants to their individual accounts through payroll withholding. Additionally, the 401(k) plan allows the Company to make contributions at the discretion of management. During the years ended December 31, 2024 and 2025, the Company matched 100% of the first 4% of participants' contributions to their 401(k) accounts, up to a maximum Company match of 4% of eligible compensation. The Company's matching contributions are made in conjunction with each payroll cycle with a true-up contribution made in the first quarter of the following year.

Stockholder Engagement and Say-on-Pay Feedback

The Company and its Compensation Committee value the opinions of our stockholders, and we believe that the feedback we receive from our stockholders is important to consider in the course of making decisions with respect to our executive compensation program and corporate governance framework.

Following the 2025 Say on Pay Vote, which received 73.7% support, at the request of our Compensation Committee, our General Counsel & Corporate Secretary reached out to stockholders representing over 60% of the outstanding shares of our common stock as of September 15, 2025. The Chair of our Compensation Committee led meetings with stockholders representing over 28% of the outstanding shares of our common stock as of September 15, 2025 to discuss our executive compensation program and other topics of interest to them, including our corporate governance framework, to gain a better understanding of their views on these topics and ways in which we could enhance the disclosures in our proxy statements to better demonstrate our alignment with their interests. Our General Counsel & Corporate Secretary and our Vice President of People & Culture (and, in one instance, our Chief Executive Officer) participated in these meetings as invited guests and as needed to answer questions. During these meetings, stockholders noted their earlier concerns with the single-trigger change in control provisions in prior versions of the Company's employment agreements with its named executive officers and expressed support for more detailed disclosure regarding the Company's compensation philosophy, equity compensation design and non-equity incentive plan framework and metrics in the Company's proxy statements. The perspectives we heard from our stockholders were conveyed to all members of the Board and were reviewed and considered by the relevant Board committees.

In response to the results of the 2025 Say on Pay Vote and the discussions during the stockholder engagement described above, we have implemented significant changes to our executive compensation and corporate governance practices. Such changes and enhancements include the following:

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The Compensation Committee and the Board will continue to consider stockholder feedback and the outcomes of future say-on-pay votes when evaluating our executive compensation programs and policies and making compensation decisions for our named executive officers.

Outstanding Equity Awards at Fiscal Year-End

The following Outstanding Equity Awards at Fiscal Year-End table sets forth information concerning unexercised stock options for each of our named executive officers as of December 31, 2025.

Employment Agreements and Separation Agreements

The following is a discussion of the material terms of each contract, agreement, plan or arrangement that provides for payments to our named executive officers at, following, or in connection with the resignation, retirement or other termination of such named executive officers, or a change in control of our company or a change in the named executive officer's responsibilities following a change in control, with respect to each named executive officer.

Current Employment Agreements with our Named Executive Officers

On November 3, 2025, the Company entered into amended and restated employment agreements with Mr. Spoor and Dr. Puhlmann to, among other things, revise certain provisions applicable in connection with a Change in Control (as that term is defined in the amended and restated employment agreements). As noted above under "Stockholder Engagement and Say-on-Pay Feedback," the amended agreements include updates such as the removal of

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single-trigger equity acceleration features. The terms of these agreements were on the same form used for the employment agreement for Mr. Sendek (together with Mr. Spoor and Dr. Puhlmann, the "Executives," and each, an "Executive") when he joined the Company in September 2025.

Under the employment agreements, each Executive may be eligible for periodic increases of his annual salary as determined by the Company in its sole discretion. Further, each Executive's annual salary may not be decreased without his written consent, other than as part of a general arrangement implemented by the Board affecting all of the Company's senior executive officials.

Additionally, each Executive is eligible for an annual cash incentive bonus as periodically established by the Compensation Committee. The payment of any cash bonus is based upon the assessment by the Compensation Committee (and, in the case of the bonus of the Chief Executive Officer, the full Board) of the performance of the Company against metrics established by the Compensation Committee each year. See "Non-Equity Incentive Plan Compensation" above for additional information. Each Executive is also eligible to participate in and receive stock options under the 2020 Equity Incentive Plan. See "Equity-Based Compensation" above for additional information.

Pursuant to the terms of the employment agreements, each Executive is an "at-will" employee. Either the Executive or the Company can terminate his employment with or without Cause (as that term is defined in the employment agreements), for any reason or no reason, and at any time. If an Executive's employment ends due to mutual written agreement with the Company, or an Executive resigns or is terminated for Cause, the Company will pay the Executive's accrued but unpaid wages and approved but unreimbursed business expenses. If an Executive is terminated without Cause or resigns for Good Reason (as that term is defined in the employment agreements), in either case outside of a CIC Protection Period (as defined below), the Company will pay the Executive's accrued but unpaid wages, approved but unreimbursed business expenses, 12 months of severance based on the Executive's then-current base salary, a pro-rated amount of the Executive's target annual discretionary bonus based on the number of full months the Executive has been employed during the fiscal year of termination, and COBRA premiums for up to 12 months of coverage.

Pursuant to the terms of the employment agreements, if an Executive's employment is terminated without Cause (as that term is defined in the employment agreements) or if an Executive resigns for Good Reason (as defined in the employment agreements), in either case during a period beginning three months prior to a Change in Control and ending 12 months after the Change in Control (a "CIC Protection Period"), then, subject to such Executive signing and delivering a release of claims in favor of the Company (a "Release") and satisfying certain other terms and conditions set forth in the employment agreements, the Company will pay such Executive's earned but unpaid wages through the termination date, approved but unreimbursed business expenses, and the following: (i) an amount equal to 12 months of salary (or, in the case of Mr. Spoor, 18 months of salary) based on the applicable Executive's then-current base salary; (ii) a pro-rated amount of the applicable Executive's target annual discretionary bonus based on the number of full months such Executive has been employed during the fiscal year of such Executive's termination; (iii) an additional amount equal to the applicable Executive's target annual discretionary bonus (or, for Mr. Spoor, an additional amount equal to his target annual discretionary bonus multiplied by 1.5); and (iv) COBRA premiums for up to 12 months of coverage (or, in the case of Mr. Spoor, 18 months of coverage). In addition, in the event of a Change in Control, with respect to any options or other Company equity-based awards held by the applicable Executive that are assumed, replaced or continued by the Company or successor entity, if such Executive's employment is terminated without Cause or if such Executive resigns for Good Reason, in either case within a CIC Protection Period, such options or other Company equity-based awards (or in the event of replacement, replacement awards) that are subject solely to time-based vesting conditions automatically (subject to such Executive's execution of a Release) shall become fully vested and, if subject to exercise, exercisable, and any other equity-based awards (or replacement awards) that are subject to performance-based vesting conditions automatically (subject to such Executive's execution of a Release) shall become vested and, if subject to exercise, exercisable, at target levels of performance, in each case as of immediately prior to the qualifying termination (or, if the qualifying termination precedes the Change in Control, immediately prior to the Change in Control). In addition, in the event of a Change in Control, with respect to any options or other Company equity-based awards held by the applicable Executive that are neither assumed, replaced nor continued, such options or other Company equity-based awards that are subject solely to time-based vesting conditions automatically shall become fully vested and, if subject to exercise, exercisable, and any other such equity-based awards that are subject to performance-based vesting conditions automatically shall

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become vested and, if subject to exercise, exercisable, at target levels of performance, in each case subject to such Executive remaining employed by the Company in good standing through the consummation of the Change in Control.

Each Executive is subject to standard confidentiality provisions and non-solicitation covenants for one year following termination of employment.

Past Employment Agreement and Separation Agreement with our Former Chief Financial Officer

The Company previously entered into an employment agreement with Juan Graham, our former Chief Financial Officer, which was effective as of January 2025 (the "Graham Agreement"). Pursuant to the Graham Agreement, Mr. Graham received an annual base salary of $500,000 and was eligible for an annual bonus based on a target bonus opportunity of 40% of his annual base salary, based upon metrics established by the Compensation Committee. See "Non-Equity Incentive Plan Compensation" above for additional information. The Graham Agreement provided for certain payments and benefits upon any of several events of termination of employment, including termination of employment upon a Change in Control (as defined in the Graham Agreement).

In connection with the not-for-cause termination of Mr. Graham as our Chief Financial Officer, the Company and Mr. Graham entered into a separation agreement on September 4, 2025 (the "Separation Agreement"), pursuant to which the Company agreed to pay Mr. Graham certain amounts to which he was entitled under the Graham Agreement in connection with a not-for-cause termination, namely (i) $500,000, minus required withholdings, to be paid biweekly in accordance with the Company's regular payroll practice, (ii) $116,666.67 as a pro-rated Target Bonus (as defined in the Graham Agreement), and (iii) $32,750 for payment of health insurance premiums for a period of one year. Subject to the terms of the Company's Third Amended and Restated 2020 Equity Incentive Plan pursuant to which the options were granted, none of Mr. Graham's equity awards had vested prior to his separation from the Company, and thus all of his equity awards were canceled.

The Separation Agreement contains a release by Mr. Graham of any and all issues and claims he may have against the Company in any way related to his employment with or separation from employment with the Company, including a release of any liabilities and claims under any local, state, or federal statutes, wage claims, and claims of discrimination. The Separation Agreement does not impact any future claims that Mr. Graham may have for previously vested benefits under any Company-sponsored benefits plan of the Company or its affiliates. The Separation Agreement was filed as an exhibit to the Annual Report on Form 10-K.

Role of the Compensation Consultant

Pursuant to its Charter, the Compensation Committee has the authority to engage independent compensation consultants and other professionals to assist in the design, formulation, analysis, and implementation of compensation programs for our executive officers. In 2025, the Compensation Committee engaged Aon to review various elements of the Company's overall compensation program, including performing reviews of the Company's 2025 executive compensation plans and programs.

Role of Benchmarking and Peer Groups

As part of our pay philosophy, our executive compensation program is designed to attract, motivate and retain our executives in an increasingly competitive market. To this end, in 2025 we evaluated industry-specific and general market compensation practices and trends to ensure that our program features and named executive officer pay opportunities remain appropriately competitive. When determining salaries, target bonus opportunities and long-term incentive grants for our named executive officers, the Compensation Committee considers the performance of the Company and the individual, the nature of an individual's role within the Company, experience in the officer's current role, as well as input from its independent compensation consultant, among other variables.

In 2024, to facilitate its review and determination of executive compensation for 2025, the Compensation Committee engaged Aon to conduct a comprehensive competitive review of our executive compensation program. In connection with this review, in May 2024, Aon identified - and the Compensation Committee approved - a peer group consisting of the following 21 pharmaceutical and biotechnology companies roughly similar to the Company in market capitalization and focused on cancer treatments to the extent possible:

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In July 2025, to facilitate the Compensation Committee's review and determination of executive compensation for 2026, Aon identified - and the Compensation Committee approved - a peer group consisting of the following 20 pharmaceutical and biotechnology companies:

The Compensation Committee and (for Mr. Spoor) the Board takes into account the peer group data in determining the base salaries, non-equity incentive plan opportunity and equity plan compensation for each named executive officer.

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Per SEC rules, CAP is calculated by adjusting the Summary Compensation Table ("SCT") "Total" values for the applicable period as described in the footnotes to the table.

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The following graphs illustrate the relationship during 2025, 2024, and 2023 of the CAP for our two PEOs noted above and the average CAP for our other NEOs as calculated pursuant to SEC rules to (i) our cumulative TSR and (ii) our net loss (each as set forth in the table above). Note that we do not utilize TSR or net loss in our executive compensation program; however, we do utilize several other performance measures to align executive compensation with the Company's performance. See the "Compensation of Directors and Executive Officers" section of this Proxy Statement for a description of the compensation setting process for our executive officers, including a description of the performance-based cash bonus component of our compensation program, which is designed to provide appropriate incentives to our executives to achieve defined annual corporate goals and to reward our executives for individual achievement towards these goals.

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Director Compensation

The Board evaluates non-employee director compensation annually based on benchmarking by Aon against the compensation paid to non-employee directors at peer group companies. The Company's non-employee director compensation policy, most recently updated by the Board in February 2025, provides for the following cash compensation for our non-employee directors: (i) a $60,000 annual cash retainer; (ii) an additional annual cash retainer of $30,000 for service as Chair of the Board; and (iii) additional annual cash retainers for committee chairs equal to $15,000. Additionally, each incumbent non-employee director is granted 50,000 stock options annually (provided that in no event shall the grant date fair value of any annual grant to an incumbent director exceed $300,000), with 100% of the options vesting on the first anniversary of the grant date. Each newly appointed or elected director is granted 75,000 options (provided that in no event shall the grant date fair value of any "new director" grant exceed $450,000), with such grant vesting in 36 monthly installments beginning on the date that is one month after the grant date. Employee directors do not receive any compensation for their service on the Board. In January 2026, the Board voted to maintain these compensation levels for 2026.

2025 Director Compensation

The following table sets forth information concerning the compensation of the non-employee directors of the Company who served for all or a portion of the year ended December 31, 2025. Johan (Thijs) Spoor, our CEO and a director, did not receive any compensation for his service on the Board in 2025. Mr. Spoor's compensation for service as an employee in 2025 is presented in "Executive Officer Compensation - Summary Compensation Table" above.

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Clawback Policy

In order to align further management's interests with the interests of our stockholders and to support good corporate governance practices, the Board has adopted an incentive compensation recovery policy, also known as a "clawback" policy. Subject to rules of the SEC and NYSE American, in the event that we are required to prepare an accounting restatement due to material noncompliance with any financial reporting requirement under the federal securities laws, the Compensation Committee has the authority to determine the appropriate means of recovering from any of our current or former executive officers, as determined in accordance with such rules, who received performance-based compensation (including stock options awarded as compensation) during the period for which we are required to prepare an accounting restatement, based on the erroneous data, in excess of what would have been paid to the executive officer under the accounting restatement. The Compensation Committee may also take any other actions authorized by our Incentive Compensation Recovery Policy. A copy of our incentive compensation recovery policy was filed as Exhibit 97 to the Annual Report on Form 10-K.

Code of Ethics

We have adopted a Code of Conduct and Ethics that applies to all of our officers, directors and employees and an additional Code of Ethics for Senior Leadership applicable to our Chief Executive Officer and all Senior Financial Officers that supplements our Code of Conduct and Ethics (together, the "Codes").

The Codes are available to the public on our website at https://www.perspectivetherapeutics.com/investors/corporate-governance. Each of these Codes comprises written standards that are reasonably designed to deter wrongdoing and to promote the behavior described in Item 406 of Regulation S-K promulgated by the Securities and Exchange Commission. Any amendments to or waivers of the Codes must be promptly posted on our website at www.perspectivetherapeutics.com or in a Report on Form 8-K, as required by applicable laws. We intend to satisfy the disclosure requirement under Item 5.05 of Form 8-K regarding any amendment to, or waiver from, a provision of the Codes by posting such information on the website address and location specified above.

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Insider Trading Policy and Prohibition on Hedging and Pledging

The Board has adopted an insider trading policy (the "Insider Trading Policy") that governs purchases, sales and other trades in Company securities by our directors, officers and other employees, as well as family members, other members of a person's household and entities controlled by a person covered by the Insider Trading Policy (collectively, "Covered Persons"). The policy is reasonably designed to promote compliance with insider trading laws, rules and regulations and applicable listing standards. Among other things, the Insider Trading Policy prohibits Covered Persons from engaging in transactions in Company securities while aware of material nonpublic information about the Company. It is also the policy of the Company to comply with all applicable securities laws when transacting in its own securities.

Additionally, under the Insider Trading Policy, our directors, officers, other employees and other Covered Persons are prohibited from engaging in the following transactions at any time: (i) short sales of our securities; (ii) trading in put options, call options or other derivative securities on an exchange or in any other organized market; (iii) hedging or monetization transactions, including through the use of financial instruments such as prepaid variable forwards, equity swaps, collars and exchange funds; and (iv) holding our securities in a margin account or otherwise pledging our securities as collateral for loan.

A copy of the Insider Trading Policy was filed as Exhibit 19.1 to the Annual Report on Form 10-K.

Equity Grant Policies and Practices

We do not have a formal policy, program or plan that requires us to award equity or equity-based compensation on specific dates. The Board and the Compensation Committee typically approve annual equity awards at or shortly following regularly scheduled Board or Compensation Committee meetings in the first quarter of each fiscal year. Equity awards for new hires are generally made on a new employee's first day of employment. All awards are granted under a stockholder-approved plan, with the grant date of any award being no earlier than the date on which such award is approved, and the grant price of any award being no less than the closing price for a share of our common stock on the grant date. The Board and the Compensation Committee do not take material nonpublic information into account when determining the timing and terms of option and option-like equity awards. Further, the Board and the Compensation Committee have not timed, and do not plan to time, the disclosure of material nonpublic information for the purpose of affecting the value of equity compensation.

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Securities Authorized for Issuance Under Equity Compensation Plans

As of December 31, 2025, the following outstanding options had been granted under the 2020 Incentive Plan, the 2017 Incentive Plan and the 2006 Director Stock Option Plan (which has now expired).

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TRANSACTIONS WITH RELATED PERSONS

Review, Approval or Ratification of Transactions with Related Persons

The Company has adopted a written Related Party Transaction Policy and general corporate governance practices that provide for Board-level discussion and assessment of procedures for discussing and assessing relationships, including business, financial, familial and nonprofit, among the Company and its directors, director nominees, executive officers or beneficial owners of more than 5% of our common stock, or any members of their immediate family, to the extent that they may arise. The Board and the Audit Committee review any transaction with an officer or director or their immediate family members to determine, on a case-by-case basis, whether a conflict of interest exists. The Board ensures that all directors voting on such a matter have no interest in the matter and discusses the transaction with counsel as the Board deems necessary. The Board will generally delegate the task of discussing, reviewing and approving transactions between the Company and any related persons to the Audit Committee. The Audit Committee approved each of the transactions described below.

Transactions with Related Persons

Except as disclosed below, there have been no such related-person transactions since January 1, 2024 to which we have been a party in which the amount involved exceeded or will exceed the lesser of $120,000 and one percent of the average of our total assets at year end for the last two completed fiscal years, and in which any of our directors, director nominees, executive officers or beneficial owners of more than 5% of our common stock, or any members of their immediate family, had or will have a direct or indirect material interest, other than compensation arrangements that we have entered into with our executive officers and directors.

Lantheus Agreements

As of April 2, 2026, Lantheus Alpha (together with Lantheus Holdings, "Lantheus") owned approximately 10.24% of our outstanding common shares and is a "related person" for purposes of the SEC rules. For clarity, Lantheus was not a related party at the time we entered into each of the Lantheus Investment Agreement, the Progenics APA and the Option Agreement (as such agreements are defined below); Lantheus became a related party upon consummation of the transactions contemplated by such agreements.

Investment Agreement

On January 8, 2024, the Company entered into an investment agreement (the "Lantheus Investment Agreement") with Lantheus, pursuant to which the Company agreed to sell and issue to Lantheus in a private placement transaction (the "Lantheus Private Placement") certain shares (the "Lantheus Shares") of the Company's common stock. The closing of the purchase and sale of the Lantheus Shares to Lantheus by the Company (the "Lantheus Closing") was subject to the Company raising at least $50.0 million of gross proceeds (excluding Lantheus' investment) in a qualifying third-party financing transaction, which occurred on January 22, 2024. The number of Lantheus Shares sold was 5,634,235, representing 19.99% of the outstanding shares of the Company's common stock as of January 8, 2024. The Lantheus Shares were sold at a price of $3.70 per share, for gross proceeds to the Company of approximately $20.8 million. Pursuant to the Lantheus Investment Agreement, the Company agreed to cooperate in good faith to negotiate and enter into a registration rights agreement with Lantheus, obligating the Company to file a registration statement on Form S-3 with the SEC to register for resale the Lantheus Shares issued at the Lantheus Closing (the "Registration Statement"). The Company filed the Registration Statement on March 29, 2024, and the SEC declared it effective on April 9, 2024. The Lantheus Investment Agreement also contains agreements between Perspective and Lantheus whereby Lantheus is provided certain board observer and information rights, subject to certain exceptions.

The Lantheus Investment Agreement also provides Lantheus with certain pro rata participation rights to maintain its ownership position in the Company in the event that the Company makes any public or non-public offering of any equity or voting interests in the Company or any securities that are convertible or exchangeable into (or exercisable for) equity or voting interests in the Company, subject to certain exceptions.

Pursuant to the Lantheus Investment Agreement, the Company is required to notify Lantheus within 10 business days of the end of a fiscal quarter in which the Company issued shares of its common stock pursuant to "at the market" sales programs, including that certain that certain Controlled Equity OfferingSM Sales Agreement with Cantor

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Fitzgerald & Co. and RBC Capital Markets, LLC (the "ATM Agreement"), of (i) the number of shares of the Company's common stock issued during such fiscal quarter pursuant to the ATM Agreement and (ii) the average price per share received by the Company before commissions (the "ATM Average Price"). Upon receipt of such notice, Lantheus may elect, at its option, to purchase all or a portion of its Pro Rata Portion (as defined in the Lantheus Investment Agreement) of such shares at an aggregate price equal to the number of shares purchased multiplied by the ATM Average Price for such quarter (the "ATM Participation Right"). Pursuant to the Lantheus Investment Agreement, Lantheus may not exercise the ATM Participation Right more than two times per calendar year.

Asset Purchase Agreement

On January 8, 2024, the Company entered into an Asset Purchase Agreement (the "Progenics APA") with Progenics Pharmaceuticals, Inc., a Delaware corporation and affiliate of Lantheus ("Progenics"), pursuant to which the Company acquired certain assets and the associated sub-lease of Progenics' radiopharmaceutical manufacturing facility in Somerset, New Jersey for a purchase price of $8.0 million in cash. The transactions contemplated by the Progenics APA closed on March 1, 2024.

Option Agreement

On January 8, 2024, the Company entered into that certain Option Agreement (the "Option Agreement") with Lantheus whereby Lantheus was granted an exclusive option to negotiate an exclusive, worldwide, royalty- and milestone-bearing right and license to [212Pb]VMT-α-NET, the Company's clinical-stage alpha therapy developed for the treatment of neuroendocrine tumors and a right to co-fund the Investigational New Drug ("IND") application, enabling studies for early-stage therapeutic candidates targeting prostate-specific membrane antigen and gastrin-releasing peptide receptor and, prior to IND filing, a right to negotiate for an exclusive license to such candidates. In consideration of the rights granted by the Company to Lantheus pursuant to the Option Agreement, Lantheus paid the Company a one-time payment of $28.0 million, subject to certain withholding provisions associated with the closing of the Progenics APA.

Under the terms of the Option Agreement, Lantheus also had a right of first offer and last look protections for any third-party merger and acquisition transactions involving the Company, which expired on January 8, 2025.

March 2024 Private Placement

On March 4, 2024, the Company entered into an investment agreement with certain accredited institutional investors pursuant to which the Company agreed to issue and sell, in a private placement, 9,200,998 shares of its common stock for a purchase price of $9.50 per share (with numbers adjusted to reflect the 1-for-10 reverse stock split effected by the Company on June 14, 2024) (the "March 2024 Private Placement"). The gross proceeds to the Company from the March 2024 Private Placement were approximately $87.4 million, before deducting fees payable to the Placement Agents (as defined therein) and other transaction expenses. Lantheus purchased 6,043,103 of the shares of common stock sold as part of the March 2024 Private Placement, resulting in approximately $57.4 million in gross proceeds, before deducting the fees as described above.

August 2024 License and Access Agreement

In August 2024, Perspective assumed a lease from Progenics for office space in Somerset, New Jersey (the "Somerset Office"). The lease terminates in November 2028. The Somerset Office lease expense is approximately $14,000 per month for 8,200 square feet. Upon assuming the lease, Perspective entered into a license and access agreement with Lantheus, which provides access to both dedicated and shared space at the Somerset Office of approximately 1,700 square feet and 1,150 square feet, respectively. There is no renewal option, and termination options are available only for material breaches.

Director Independence

As discussed elsewhere in this Proxy Statement, using the NYSE American listing standards, the Company's Board has determined that Heidi Henson, Maya Martinez-Davis, Frank Morich, M.D., Ph.D., Robert Froman Williamson, III and Lori A. Woods each meet the NYSE American listing standards for independence both as directors and under the standards for membership on the Audit Committee. The Board has affirmatively determined that each

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of the members of the Compensation Committee is "independent" as independence is defined in Section 805(c) of the NYSE American listing standards and Rule 10C-1 under the Exchange Act.

None of our existing directors were disqualified from independent status under the objective standards of the NYSE American other than Mr. Spoor, who did not qualify as he is an employee director. In reviewing the subjective criteria of "any relationship that would interfere with the exercise of independent judgment" in carrying out the responsibilities of a director, the Board determined that all directors, other than Mr. Spoor, met this criterion as well.

The Company did not consider any other relationship or transaction between itself and these independent directors not already disclosed in this proxy statement in making these independence determination.

Director and Officer Indemnification

Our Certificate of Incorporation provides to our directors and officers indemnification to the fullest extent provided by Delaware law, and provides that, to the fullest extent permitted by Delaware law, directors will not be personally liable for monetary damages to us or our stockholders for breach of his or her fiduciary duty as a director, except for liability (i) for any breach of the director's duty of loyalty to us or our stockholders, (ii) for acts or omissions not in good faith, or which involve intentional misconduct, or a knowing violation of the law, (iii) illegal distributions to stockholders or unlawful stock repurchases, or (iv) for any transaction from which the director derived an improper personal benefit.

In addition, we have entered into indemnification agreements with each of our directors and executive officers, pursuant to which we have agreed to indemnify such individuals for any claims made against such individuals based on any act, omission or breach of duty committed while acting as director or officer, except under certain circumstances such as cases involving dishonesty or improper personal benefit. We also maintain an insurance policy under which our directors and officers are insured against certain liabilities which might arise out of their relationship with us as directors and officers.

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OTHER INFORMATION

Other Business

It is not anticipated that there will be any business presented at the Annual Meeting other than the matters set forth in the Notice of Annual Meeting attached hereto. As of the date of this Proxy Statement, we were not aware of any other matters to be acted on at the Annual Meeting. If any other business should properly come before the Annual Meeting or any adjournment thereof, the persons named on the enclosed proxy will have discretionary authority to vote such proxy in accordance with their best judgment.

Stockholder Communications with the Board

The Company provides for a process for stockholders to send communications to the Board. To contact members of the Board, individually or collectively, on any subject, please address that communication to:

Chris Nenno, General Counsel and Corporate Secretary

Perspective Therapeutics, Inc.

2401 Elliott Avenue, Suite 320

Seattle, WA 98121

The mailing envelope for your communication should contain a clear notation that the enclosed letter is a "Stockholder Communication with Directors" and clearly identify the intended recipient(s) of the communication. The Company's General Counsel and Corporate Secretary will review each communication received from stockholders and other interested parties and will forward the communication, as expeditiously as reasonably practicable, to the addressee(s) if (1) the communication complies with the aforementioned requirements and (2) the communication falls within the scope of matters generally considered by the Board. To the extent the subject matter of a communication relates to matters that have been delegated by the Board to a committee or to an executive officer of the Company, then the Company's General Counsel and Corporate Secretary may forward the communication to the executive officer or chair of the committee to which the matter has been delegated. The acceptance and forwarding of communications to the members of the Board or an executive officer does not imply or create any fiduciary duty of the Board members or executive officer to the person submitting the communications.

Board Attendance at Annual Meeting

The Company's corporate governance guidelines encourage, but do not require, Board members to attend the Company's annual meetings of stockholders. All Board members attended the most recent annual meeting.

Expenses of Solicitation

The Company will bear the entire cost of this solicitation of proxies, including the preparation, assembly, printing and mailing of the Notice Regarding the Availability of Proxy Materials, this Proxy Statement, the proxy, and any additional solicitation material that the Company may provide to stockholders. Proxies will be primarily solicited by mail.

Some of our directors, officers, and other employees may, but without compensation other than their regular compensation, solicit proxies by further mailing or personal conversations, or by telephone, facsimile, or other electronic means.

The Company will also request brokers, banks and other nominees to forward solicitation materials to the beneficial owners of shares of common stock as of the Record Date and will reimburse such persons for the cost of forwarding the solicitation materials in accordance with customary practice. Your cooperation in promptly voting your shares and submitting your proxy by telephone, the Internet or by completing and returning the proxy card if you receive one by mail will help to avoid additional expense. Proxies and ballots will be received and tabulated by Broadridge, and the Company's General Counsel and Corporate Secretary, Chris Nenno, will serve as the inspector of elections for the Annual Meeting.

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Stockholder Proposals and Director Nominations

In accordance with Rule 14a-8 under the Exchange Act ("Rule 14a-8"), if a stockholder wishes to present a proposal for inclusion in the Company's proxy materials for the 2027 Annual Meeting of Stockholders (the "2027 Annual Meeting"), the Company's Corporate Secretary must receive written notice of such proposal at the Company's executive offices at 2401 Elliott Avenue, Suite 320, Seattle, Washington 98121 no later than the close of business on December 17, 2026, the date that is 120 days prior to the first anniversary of the date this Proxy Statement was first released to stockholders, in order to be considered timely under SEC rules. However, in accordance with Rule 14a-8, if the date of the 2027 Annual Meeting is changed by more than 30 days from the first anniversary date of the 2026 Annual Meeting, then the deadline will be a reasonable time before the Company begins to print and send its proxy materials for the 2027 Annual Meeting. Any such proposal shall be subject to the requirements of the proxy rules adopted under the Exchange Act.

In accordance with the advance notice procedures set forth in the Company's bylaws, if a stockholder wishes to bring business before the 2027 Annual Meeting outside of Rule 14a-8 or to nominate a person for election as a director at the 2027 Annual Meeting, such proposal must be delivered to the Company's Corporate Secretary at the Company's principal executive offices not earlier than the close of business on the 120th day and not later than the close of business on the 90th day prior to the first anniversary of the preceding year's annual meeting. Therefore, to be presented at the 2027 Annual Meeting, the Company must receive such a proposal not earlier than the close of business on January 27, 2027, and not later than the close of business on February 26, 2027, in order to be considered timely. However, if the date of the 2027 Annual Meeting is a date that is more than 30 days before or more than 60 days after the anniversary date of the 2026 Annual Meeting, notice by the stockholder must be delivered not earlier than the close of business on the 120th day prior to the date of the 2027Annual Meeting and not later than the close of business on the later of the 90th day prior to the date of the 2027 Annual Meeting or, if the first public announcement of the date of the 2027 Annual Meeting is less than 100 days prior to the date of such annual meeting, the 10th day following the day on which public announcement of the date of the 2027 Annual Meeting is first made by the Company. Any such proposal must contain the information specified in, and otherwise comply with, the Company's bylaws. Any such proposal must be delivered to: Perspective Therapeutics, Inc., Attn: Corporate Secretary, 2401 Elliott Avenue, Suite 320, Seattle, Washington 98121. Stockholders are advised to review the Company's bylaws, which contain additional requirements with respect to advance notice of stockholder proposals and director nominees.

In addition to satisfying the procedures set forth in the Company's bylaws, to comply with the universal proxy rules under the Exchange Act, stockholders who intend to solicit proxies in support of director nominees at the Company's 2027 Annual Meeting other than the Company's nominees must provide notice that sets forth the information required by Rule 14a-19 under the Exchange Act, no later than March 29, 2027, which is the first business day following the 60th calendar day prior to the anniversary of the 2026 Annual Meeting. However, if the date of the 2027 Annual Meeting has changed by more than 30 days from the first anniversary date of the 2026 Annual Meeting, then notice must be provided by the later of (i) 60 days prior to the date of the 2027 Meeting or (ii) the 10th day following the day on which public announcement of the date of the 2027 Annual Meeting is first made by the Company.

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HOUSEHOLDING

Unless contrary instructions are received, we may send a single copy of the Proxy Statement and Notice of Annual Meeting to any household at which two or more stockholders reside. Each stockholder in the household will continue to receive a separate proxy card. This process is known as "householding" and helps reduce the volume of duplicate information received at a single household, which reduces costs and expenses borne by us.

If you would like to receive a separate set of our annual disclosure documents this year or in future years, follow the instructions described below, and we will deliver promptly a separate set. Similarly, if you share an address with another stockholder and the two of you would like to receive only a single set of our annual disclosure documents, follow the instructions below:

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MISCELLANEOUS

The Board knows of no other matters to be presented at the Annual Meeting. If any other business properly comes before the Annual Meeting or any adjournment thereof, the proxies will vote on that business in accordance with their best judgment.

By Order of the Board of Directors,

/s/ Chris Nenno

Chris Nenno, General Counsel and Corporate Secretary

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PERSPECTIVE THERAPEUTICS, INC. 2401 ELLIOTT AVENUE, SUITE 320 SEATTLE, WA 98121 SCAN TO VIEW MATERIALS & VOTE VOTE BY INTERNET - www.proxyvote.com or scan the QR Barcode above Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time on May 26, 2026. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form. ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALS If you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years. VOTE BY PHONE - 1-800-690-6903 Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time on May 26, 2026. Have your proxy card in hand when you call and then follow the instructions. VOTE BY MAIL Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717. TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS: V92320-P47541 THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. KEEP THIS PORTION FOR YOUR RECORDS DETACH AND RETURN THIS PORTION ONLY PERSPECTIVE THERAPEUTICS, INC. The Board of Directors of Perspective Therapeutics, Inc. (the "Company") recommends you vote "FOR ALL" of the nominees for Proposal 1: 1. Election of Directors Nominees: 01) Lori A. Woods 02) Heidi Henson 03) Robert Froman Williamson, III 04) Frank Morich, M.D., Ph.D. 05) Johan (Thijs) Spoor 06) Maya Martinez-Davis For All Withhold All For All Except To withhold authority to vote for any individual nominee(s), mark "For All Except" and write the number(s) of the nominee(s) on the line below. The Board of Directors of the Company recommends you vote "FOR" Proposal 2: For Against Abstain 2. To ratify the appointment of WithumSmith+Brown, PC as the independent registered public accounting firm of the Company for the fiscal year ending December 31, 2026. The Board of Directors of the Company recommends you vote "1 YEAR" on Proposal 3: 1 Year 2 Years 3 Years Abstain 3. To approve, on a non-binding advisory basis, the frequency of advisory stockholder votes on the compensation of the Company's named executive officers. Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. Signature [PLEASE SIGN WITHIN BOX] Date Signature (Joint Owners) Date

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting: The Notice and Proxy Statement and Annual Report on Form 10-K are available at www.proxyvote.com. V92321-P47541 REVOCABLE PROXY PERSPECTIVE THERAPEUTICS, INC. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS The undersigned hereby appoints Johan (Thijs) Spoor and Joel Sendek, and each of them or either of them, as proxies, with full power of substitution and revocation, to act for and in the name of the undersigned to vote all shares of common stock of Perspective Therapeutics, Inc. (the "Company") that the undersigned is entitled to vote at the 2026 Annual Meeting of Stockholders of the Company, to be held at the Sheraton Grand Chicago Riverwalk, 301 E North Water Street, Chicago, IL 60611, on Wednesday, May 27, 2026, at 9:00 a.m. Central Time, and at any and all adjournments or postponements thereof, as indicated on the reverse side. This proxy card will be voted as directed. If no instructions are specified, this proxy card will be voted "FOR ALL" on proposal 1, "FOR" proposal 2 and "1 YEAR" on proposal 3. The undersigned hereby authorizes the proxies to vote their shares of common stock in such proxies' discretion if any other business is properly presented at the 2026 Annual Meeting of Stockholders of the Company or any adjournments or postponements thereof. At the present time, the Board of Directors knows of no other business to be presented at the Annual Meeting. The undersigned may revoke this proxy card at any time prior to its use (1) by providing a written notice of revocation to Corporate Secretary, 2401 Elliott Avenue, Suite 320, Seattle, WA 98121, (2) by granting a new proxy bearing a later date that is timely received by the Company or (3) by voting in person at the 2026 Annual Meeting of Stockholders of the Company. Continued and to be signed on reverse side