Registration Statement - Specified Transactions (Form S-3)

As filed with the Securities and Exchange Commission on June 2, 2026

Registration No. 333-275088

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-3

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

MILESTONE SCIENTIFIC INC.

(Exact name of registrant as specified in its charter)

Delaware		13-3545623
(State or other jurisdiction of		(IRS Employer
incorporation or organization)		Identification Number)

425 Eagle Rock Avenue, Suite 403

Roseland, New Jersey 07068

(973) 535-2717

(Address, including zip code, and telephone number,

including area code, of registrant's principal executive offices)

Eric Hines

Chief Executive Officer

Milestone Scientific Inc.

425 Eagle Rock Ave, Suite 403

Roseland, New Jersey 07068

(973) 535-2717

(Name, address, including zip code, and telephone number,

including area code, of agent for service)

Copy to:

Lawrence M. Bell, Esq.
Tarter Krinsky & Drogin LLP
1350 Broadway, NY 10018
(212) 574-0392

From time to time after the effective date of this registration statement.

(Approximate date of commencement of proposed sale to the public)

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933 check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act:

Large accelerated filer ☐	Accelerated filer ☐	Non-accelerated filer ☒
Smaller reporting company ☒		Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the Registration Statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

The information in this prospectus is not complete and may be changed. The selling security holders may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

Subject to completion, dated June 2, 2026

PRELIMINARY PROSPECTUS

MILESTONE SCIENTIFIC INC.

7,962,963 Shares of Common Stock

7,962,963 Shares of Common Stock Underlying Warrants

This prospectus relates to the resale, from time to time by the selling stockholders named in this prospectus (the "selling stockholders") of up to 15,925,926 shares of common stock, par value $0.001 per share, which consists of up to (i) 7,962,963 shares of common stock (the "Initial Shares"), and (ii) 7,962,963 shares of common stock (the "Warrant Shares") issuable upon the exercise of warrants held by the selling stockholders (the "Warrants"). The Initial Shares and Warrant Shares shall be collectively referred to as the "Securities" or the "Shares."

Our registration of the shares of common stock covered by this prospectus does not mean that the selling stockholders will offer or sell any of such Shares. The selling stockholders received the Initial Shares and Warrants from us pursuant to a private placement transaction (the "Private Placement"), which transaction was consummated on April 20, 2026. We are registering the offer and resale of the Shares to satisfy a covenant set forth in the Registration Rights Agreement entered into on April 20, 2026 (the "Registration Rights Agreement") executed concurrently with a securities purchase agreement as of the same date with respect to the Private Placement, pursuant to which we agreed to register the resale of the Shares within a limited period of time following the date of the Registration Rights Agreement.

We will not receive any of the proceeds from the sale of our common stock by the selling stockholders. However, upon the exercise of Warrants, we will receive the exercise price of such Warrants.

Any shares of our common stock subject to resale hereunder will have been issued by us and received by the selling stockholders prior to any resale of such shares pursuant to this prospectus.

The selling stockholders, or their donees, pledgees, transferees or other successors-in-interest may offer or resell the Shares from time to time through public or private transactions at prevailing market prices, at prices related to prevailing market prices or at privately negotiated prices. The selling stockholders will bear all commissions and discounts and similar selling expenses, if any, attributable to the sale of Shares. We will bear all costs, expenses and fees (other than commissions and discounts and similar selling expenses) in connection with the registration of the Shares. For additional information on the methods of sale that may be used by the selling stockholders, see "Plan of Distribution" beginning on page 14 of this prospectus.

This prospectus describes the general manner in which the shares may be offered and sold by the selling stockholders. If necessary, the specific manner in which the shares may be offered and sold will be described in a supplement to this prospectus. Any such prospectus supplement may also add, update or change information in this prospectus. We may also authorize one or more free writing prospectuses to be provided to you in connection with this offering. You should carefully read this prospectus, any applicable prospectus supplement and any related free writing prospectuses, as well as the documents incorporated by reference or deemed to be incorporated by reference into this prospectus, carefully before you invest. For additional information on the methods of sale, you should refer to the section entitled "Plan of Distribution" in this prospectus.

Our common stock is traded on the NYSE American under the symbol "MLSS." On May 26, 2026, the closing price of our common stock on the NYSE American was $0.37 per share.

We are a "smaller reporting company" under applicable federal securities laws and, as such, have elected to comply with reduced public company reporting requirements for this prospectus and the documents incorporated by reference herein and may elect to comply with reduced public company reporting requirements in future filings. See "Summary - Implications of Being a Smaller Reporting Company."

INVESTING IN OUR SECURITIES INVOLVES RISKS. YOU SHOULD REVIEW CAREFULLY THE RISKS AND UNCERTAINTIES DESCRIBED UNDER THE HEADING "RISK FACTORS" CONTAINED IN THIS PROSPECTUS AND ANY RELATED FREE WRITING PROSPECTUS, AND UNDER SIMILAR HEADINGS IN OTHER DOCUMENTS THAT ARE INCORPORATED BY REFERENCE INTO THIS PROSPECTUS OR ANY SUCH PROSPECTUS SUPPLEMENT. SEE "RISK FACTORS" ON PAGE 5 OF THIS PROSPECTUS.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus is June 2, 2026.

TABLE OF CONTENTS

ABOUT THIS PROSPECTUS	ii
FORWARD-LOOKING STATEMENTS	ii
SUMMARY	1
THE OFFERING	4
RISK FACTORS	5
USE OF PROCEEDS	7
DESCRIPTION OF SECURITIES	7
CERTAIN PROVISIONS OF DELAWARE LAW AND OF THE COMPANY'S CERTIFICATE OF INCORPORATION AND BY-LAWS	9
SELLING STOCKHOLDERS	10
PLAN OF DISTRIBUTION	14
LEGAL MATTERS	15
EXPERTS	16
WHERE YOU CAN FIND MORE INFORMATION	16
INCORPORATION BY REFERENCE	17

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission (the "SEC" or "Commission"), utilizing a "shelf" registration process. Under this shelf process, the selling stockholders may resell, from time to time, in one or more offerings, shares of our common stock offered by this prospectus.

This prospectus provides you with a general description of the securities the selling stockholders may offer. From time to time, we may provide one or more prospectus supplements that will contain specific information about the terms of the offering. The prospectus supplement may also add, update or change information contained in this prospectus. You should read both this prospectus and any applicable prospectus supplement together with additional information described below under the headings "Where You Can Find More Information" and "Incorporation by Reference."

When acquiring any securities discussed in this prospectus, you should rely only on the information contained in this prospectus and any applicable prospectus supplement we may authorize for use in connection with such offering, including the information incorporated by reference. Neither we, nor the selling stockholders, have authorized anyone to provide you with different information. If anyone provides you with different or additional information, you should not rely on it. The selling stockholders are offering to sell and seeking offers to buy the common stock only in jurisdictions in which offers and sales are permitted. You should not assume that the information in this prospectus, any prospectus supplement, any free writing prospectus we may authorize for use in connection with such offering, or any document incorporated by reference, is truthful or complete at any date other than the date mentioned on the cover page of those documents. You should also carefully review the section entitled "Risk Factors", which highlights certain risks associated with an investment in our securities, to determine whether an investment in our securities is appropriate for you.

As used in this Registration Statement on Form S-3 (this "Form S-3"), unless the context otherwise requires, the terms "we," "us," "our," "Milestone Scientific," and the "Company" refer to Milestone Scientific Inc., a Delaware corporation, and its consolidated subsidiaries, Wand Dental, Inc. and Milestone Medical Inc., unless the context otherwise indicates.

Milestone Scientific is the owner of the following registered U.S. trademarks: CompuDent^®; CompuMed^®; CompuFlo^®; DPS Dynamic Pressure Sensing technology^®; Milestone Scientific ^®; CathCheck^®; the Milestone logo ^®; SafetyWand^®; STA Single Tooth Anesthesia Device^®; and The Wand ^®. Our names, logos and website names and addresses are our trademarks or service marks. Solely for convenience, in some cases, the trademarks, trade names and service marks referred to in this prospectus are listed without the applicable ^®, ™ and SM symbols, but they will assert, to the fullest extent under applicable law, their rights to these trademarks, trade names and service marks.

FORWARD-LOOKING STATEMENTS

This Form S-3 contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the "Securities Act"), and Section 21E of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), that are intended to be covered by the "safe harbor" created by those sections.

Forward-looking statements, which are based on certain assumptions and describe our future plans, strategies and expectations, can generally be identified by the use of forward-looking terms such as "may", "will", "should", "expect", "believe", "anticipate", "continue", "estimate", "project", "intend" and similar expressions or other comparable terms and references to future periods. All statements other than statements of historical facts included in this prospectus regarding our strategies, prospects, financial condition, operations, costs, plans and objectives are forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding expectations for revenues, cash flows and financial performance, the anticipated results of our development efforts, product features and the timing for receipt of required regulatory approvals and product launches.

Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions, and involve numerous risks and uncertainties. Our plans and objectives are based, in part, on assumptions involving the continued expansion of its business. Assumptions relating to the foregoing involve judgments with respect to, among other things, future economic, competitive, and market conditions and future business decisions, all of which are difficult or impossible to predict accurately. Although we believe that our assumptions underlying the forward-looking statements are reasonable, any of the assumptions could prove inaccurate. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

● future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond the control of Milestone Scientific,

●  we are a small, non-diversified medical device company with a history of limited revenue and significant operating losses and our prospects must be evaluated considering the uncertainties, risks, expenses, and difficulties frequently encountered by similarly situated companies,

● we have incurred significant losses since our inception, and these operating losses are expected to continue and we are unable to predict the extent of future losses, whether we will generate significant revenues, or whether we will achieve or sustain profitability,

●  our need of additional funding for our operations and that we may be unable to raise capital when needed, which may force us to delay, curtail, or eliminate parts of the Company's operations,

●  sales of a substantial number of shares of our common stock, or the perception that such sales may occur, may adversely impact the price of our common stock,

● raising additional funds by issuing securities or through licensing or lending arrangements may cause dilution to our existing stockholders, restrict our operations or require us to relinquish proprietary rights, and your percentage ownership in the Company may be diluted because of equity issuances for acquisitions, capital market transactions or otherwise, including any equity awards that the Company will grant to its directors, officers, employees and consultants,

●  our failure to regain compliance with the strict listing requirements of NYSE American may subject us to delisting. As a result, our stock price may decline, and our common stock may be de-listed. If our stock were no longer listed on NYSE American, the liquidity of our securities likely would be impaired,

● our ability to raise additional capital may be limited by a low trading volume, stock price and market capitalization, as well as by laws, regulations and market conditions,

● our financial statements have been prepared on a going concern basis, but there can be no assurance that we will be able to continue as a going concern without raising additional capital,

● the early stage operations of and relative lack of acceptance of our medical products,

●  relying exclusively on third parties to manufacture our products, changes in our informal manufacturing arrangements made by the manufacturer of our products, disruptions at the manufacturing facility of our manufacturers, and failure to maintain existing supply relationships,

● changes to our distribution arrangements expose us to risks of interruption of marketing efforts and building new marketing channels,

●  changes in our informal manufacturing arrangements made by the manufacturer of our products and disruptions at the manufacturing facility of our manufacturers, including shortages of or delays in obtaining chips and other components, expose us to risks that may harm our business,

● our sales and marketing efforts in the United States rely upon our E-Commerce platform,

● if physicians do not accept or use our CompuFlo Epidural Computer Controlled Anesthesia System, our ability to generate revenue from sales will be materially impaired,

● if our technology does not perform as expected, or if we fail to successfully develop, commercialize, or sell new or enhanced products or penetrate new markets, our business, financial condition, and operating results could be adversely affected,

● exposure to the risks inherent in international sales and operations, including China, and our business is exposed to risks associated with the economic, environmental, and political conditions in China because the sole manufacturer of our handpieces is in China,

● the changing tariff and trade policies of the United States and China, and developments by competitors may render our products or technologies obsolete or non-competitive,

●  our ability to commercialize our products will depend in part on the extent to which reimbursement will be available from governmental agencies, health administration authorities, private health maintenance organizations and health insurers, and other healthcare payers,

● healthcare reform laws and regulations significantly affect the U.S. healthcare services industry,

●  we are subject to substantial domestic and international government regulation, including regulatory quality standards applicable to our manufacturing and quality processes; failure by us to comply with these standards could have an adverse effect on our business, financial condition, or results of operations,

● changes to United States federal and state regulatory agencies may cause disruptions and delays in the approval processes and regulations relating to our products,

● issues with product quality could have a material adverse effect upon our business, subject us to regulatory actions and cause a loss of customer confidence in us or our products,

● international conflict has affected commerce worldwide, geopolitical instability, labor unrest, and economic disruptions in certain foreign jurisdictions, may have a material adverse effect on our results of operations, cash flows, and financial condition, and

● we may not be able to attract and retain qualified employees.

The inclusion of such information should not be regarded as a representation by Milestone Scientific or any other person that the objectives and plans of Milestone Scientific will be achieved. A description of some of the risks and uncertainties that could cause our actual results to differ materially from those described by the forward-looking statements in this prospectus appears in the section captioned "Risk Factors" as well as the risk factors described under the section captioned "Risk Factors" contained in our Annual Report on Form 10-K for our most recent fiscal year (together with any material changes thereto contained in subsequent filed Quarterly Reports on Form 10-Q and Current Reports on Form 8-K) and those contained in our other filings with the SEC, which are incorporated by reference in this prospectus, and elsewhere in this prospectus. Readers are cautioned not to place undue reliance on forward-looking statements because of the risks and uncertainties related to them and to the risk factors. Any forward-looking statement made by us herein is based only on information currently available to us and speaks only as of the date on which it is made. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future.

RISK FACTORS

Investing in our securities involves a high degree of risk. You should carefully consider the risk factors described below and in our Annual Report on Form 10-K for our most recent fiscal year (together with any material changes thereto contained in subsequent filed Quarterly Reports on Form 10-Q and Current Reports on Form 8-K) and those contained in our other filings with the SEC, which are incorporated by reference in this prospectus. These risk factors may be amended, supplemented or superseded from time to time by other reports we file with the SEC in the future or by a prospectus supplement relating to a particular offering of our securities. These risks and uncertainties are not the only risks and uncertainties we face. Additional risks and uncertainties not presently known to us, or that we currently view as immaterial, may also impair our business. If any of the risks or uncertainties described in our SEC filings or any prospectus supplement or any additional risks and uncertainties actually occur, our business, financial condition and results of operations could be materially and adversely affected. In that case, the trading price of our securities could decline and you might lose all or part of your investment.

We anticipate that we will need additional funding for our operations and may be unable to raise capital when needed, which may force us to delay, curtail, or eliminate parts of the Company's operations.

Our operations have consumed substantial cash since inception. Net cash used in operating activities was approximately $2.9 million for the years ended December 31, 2025, and 2024, respectively. To date, the Company has not generated sufficient revenues to provide cash flows that enable the Company to finance its operations internally. We believe our near-term viability depends on our ability to raise additional capital to finance operations through public or private equity offerings, collaborations, licensing arrangements, or other sources. Although we intend to pursue additional funding, there can be no assurance that we will obtain sufficient capital on acceptable terms, or at all. In connection with an evaluation conducted by the Company's management during the preparation of our most recent Annual Report on Form 10-K, and as amended on Form 10-K/A, management concluded that there were conditions and events which raised substantial doubt as to the Company's ability to continue as a going concern within twelve months after the date of the issuance of the financial statements included therein.

The uncertainty regarding our ability to continue as a going concern could materially adversely affect our share price and our ability to raise new capital or enter into commercial transactions. To address these matters, the Company may take actions that materially and adversely affect our business, including significant reductions in research, development, administrative and commercial activities, reduction of our employee base, and ultimately curtailing or ceasing operations, any of which could materially adversely affect our business, financial condition, results of operations and share price. In addition, doubts about our ability to continue as a going concern could impact our relationships with customers, vendors and other third parties and our ability to obtain, maintain or renew contracts with them, or negatively impact our negotiating leverage with such parties, which could have a material adverse effect on our business, financial condition, and results of operations. Furthermore, any loss of key personnel, employee attrition or material erosion of employee morale arising out of doubts about our ability to operate as a going concern could have a material adverse effect on our ability to effectively conduct our business and could impair our ability to execute our strategy and implement our business objectives, thereby having a material adverse effect on our business, financial condition, and results of operations

If we fail to regain compliance with the strict listing requirements of NYSE American, we may be subject to delisting. As a result, our stock price may decline, and our common stock may be de-listed. If our stock were no longer listed on NYSE American, the liquidity of our securities likely would be impaired.

Our common stock currently trades on the NYSE American under the symbol "MLSS". On October 8, 2025, the Company received a letter from NYSE American stating that the Company is not in compliance with the continued listing standards as outlined in Section(s) 1003(a)(ii), and (iii) of the NYSE American Company Guide (the "Company Guide").

Section 1003(a)(ii) requires a listed company to have stockholders' equity of $4 million or more if it has reported losses from continuing operations and/or net losses in three of its four most recent fiscal years, and Section 1003(a)(iii) requires stockholders' equity of $6 million or more if it has reported losses from continuing operations and/or net losses in its five most recent fiscal years. As of December 31, 2025, the Company reported stockholders' equity of approximately $2.8 million and experienced losses in such period and each of its five prior fiscal years. As a result, the Company is not currently in compliance with Sections 1003(a)(ii) and (iii) and is not eligible for any exemption under Section 1003(a) of the Company Guide.

To maintain its listing, the Company submitted a plan of compliance outlining the actions it has taken or will take to regain compliance. The Company will be able to continue its listing but will be subject to periodic reviews by the NYSE American. If the Company fails to comply with the continued listing standards by April 8, 2027, or if the Company does not make progress consistent with the plan, the NYSE American will initiate delisting procedures as appropriate. The Company's management is pursuing options to address the deficiency. In the Private Placement pursuant to which the Shares being registered were issued, we increased our stockholders' equity by approximately $1.8 million, and our stockholders' equity immediately after such transaction was $4.1 million. If we fail to regain compliance with and adhere to NYSE American's strict listing criteria, including with respect to stock price, our market capitalization and stockholders' equity, our stock may be de-listed. This would impair the liquidity of our securities not only in the number of shares that could be bought and sold at a given price, which may be depressed by the relative illiquidity, but also through delays in the timing of transactions and the potential reduction in media coverage. As a result, an investor might find it more difficult to dispose of our common stock if we are delisted. Any failure at any time to meet the continuing NYSE American listing requirements would have an adverse impact on the value of and trading activity in our common stock. There can be no assurance that we can maintain the listing of our common stock on the NYSE American.

We have historically relied on, and may continue to rely on, the sale of shares of our common stock to fund our operations and support our business activities. Our ability to raise additional capital through sales of our common stock or other securities offerings will depend on several factors, many of which may not be in our favor, including the trading volume and volatile trading price of our common stock, our relatively low public float and market capitalization, our potential inability maintain compliance with the listing requirements of the NYSE American, unfavorable financial market conditions, and the other risks and uncertainties. If we are unable to raise additional capital through the offering and sale of shares of our common stock, or securities convertible into or exercisable for our common stock, on a timely basis or on acceptable terms, or at all, we may seek additional capital through other third-party sources that require us to relinquish valuable rights in our intellectual property, technologies, product candidates or future revenue streams, or that subject us to restrictive covenants, operational restrictions or security interests in our assets, or we may need to delay, scale back or eliminate some or all of our development programs, reduce other expenses, file for bankruptcy, reorganize, merge with another entity, or cease operations.

Using a shelf registration statement to conduct an equity offering to raise capital generally takes less time and is less expensive than other means, such as conducting an offering under a Form S-1 registration statement. Our ability to raise capital under a shelf registration statement is, and may continue to be, limited by, among other things, current and future SEC rules and regulations impacting the eligibility of smaller companies to use Form S-3 for primary offerings of securities. For example, if we filed a new shelf registration statement, we currently would be subject to the "baby shelf rule." This means that we could use a shelf registration statement to raise additional funds only to the extent that the aggregate market value of securities sold by us or on our behalf pursuant to Instruction I.B.6. of Form S-3 during the 12 calendar months immediately prior to, and including, the intended sale does not exceed one-third of the aggregate market value of our public float, calculated in accordance with the instructions to Form S-3 In such calculation the Shares registered under this prospectus would not count against, or be deducted from, such public float. Based on the highest closing price of our common stock on the NYSE American during the sixty (60) trading days preceding the date of this prospectus, which was $0.48 per share, and based on our current public float, we believe we may currently have the capacity to raise sufficient capital under our shelf registration statement to satisfy NYSE American continued listing requirements. However, there is no assurance that such capacity will continue. If our ability to offer securities under a shelf registration statement is limited, including by the baby shelf rule, we could choose to conduct an offering of our securities under an exemption from registration under the Securities Act or under a Form S-1 registration statement. We would expect either of these alternatives to take more time and be a more expensive method of raising additional capital relative to using our shelf registration statement.

Our ability to raise capital on a timely basis through the issuance and sale of equity securities may also be limited by NYSE American's stockholder approval requirement for certain issuances, including certain transactions that are not deemed a public offering (as defined in the Company Guide). For transactions other than public offerings, the Company Guide requires stockholder approval prior to the issuance or potential issuance of common stock (or securities convertible into or exercisable for common stock) at a price per share that is less than the lower of the Official Closing Price immediately preceding the signing of the binding agreement or the average Official Closing Price for the five trading days immediately preceding the signing of the binding agreement, if the issuance (together with sales by our officers, directors and principal shareholders (as defined in Company Guide)) would equal 20% or more of our common stock outstanding before the issuance. Obtaining stockholder approval is a costly and time-consuming process. If we must obtain stockholder approval for a potential transaction, we would expect to spend substantial additional money and resources. In addition, seeking stockholder approval would delay our receipt of otherwise available capital, which may materially and adversely affect our ability to execute our business plan, and there is no guarantee our stockholders ultimately would approve a proposed transaction.

A sale of a substantial number of shares of common stock by the selling stockholders, or the perception that such sales may occur, could cause the price of our common stock to decline.

We are registering for resale 15,925,926 shares of our common stock consisting of Initial Shares and Warrant Shares underlying the Warrants issued to the selling stockholders to fulfill our contractual obligations under the Registration Rights Agreement. The shares of common stock that may be resold by the selling stockholders pursuant to this prospectus and without regard to beneficial ownership limitations contained in the Warrants, represent a material portion of the total outstanding shares of our common stock, and, following the effectiveness of the registration statement of which this prospectus forms a part, such shares may be sold by the selling stockholders in the public market without restriction. If the selling stockholders sell, or the market perceives that the selling stockholders intend to sell for various reasons, substantial amounts of such shares in the public market, the price of our common stock may decline. We cannot predict if and when the selling stockholders may sell such shares in the public markets. Furthermore, in the future, we may issue additional shares of our common stock or other equity or debt securities exercisable for, or convertible into, shares of our common stock. Any such issuances could result in substantial dilution to our existing stockholders and could cause our stock price to decline. Additionally, such conditions may make it more difficult for us to sell equity or equity-related securities in the future at a time and price that we deem reasonable or appropriate.

USE OF PROCEEDS

All shares of our common stock offered by this prospectus are being registered for the accounts of the selling stockholders, and we will not receive any proceeds from the sale of these shares. We will, however, bear the costs incurred in connection with the registration of these shares of common stock and, we may receive proceeds from the exercise price of the Warrants which, if exercised in full, would result in gross proceeds of approximately $2,687,500.

We intend to use the net proceeds, if any, from the cash exercise of the Warrants for general working capital purposes, including payment of past due accounts payable at that time. The amounts and timing of our actual use of the net proceeds from the exercise of Warrants will vary depending on numerous factors, including when and how much we receive upon exercise and the factors described under "Risk Factors" located elsewhere in this prospectus, or in the information incorporated by reference herein or therein. As a result, our management will have broad discretion in the application of the net proceeds from the exercise of Warrants, and investors will be relying on our judgment regarding the application of such net proceeds. We cannot predict when, or if, and if exercised how much of, the Warrants will be exercised. It is possible that the Warrants may expire and may never be exercised.

DESCRIPTION OF SECURITIES

The following summary description of our capital stock and certain provisions of our Restated Certificate of Incorporation, as amended (the "Certificate of Incorporation"), and Amended and Restated By-laws (the "By-laws"), and the applicable provisions of the General Corporation Law of the State of Delaware (the "DGCL"), may not be complete in all respects and is qualified entirely by reference to the provisions of our Certificate of Incorporation and our By-laws and the DGCL. For information on how to obtain copies of our Certificate of Incorporation and By-laws, see the discussion below under the heading "Where You Can Find More Information."

Authorized Capital

We currently have authority to issue 125,000,000 shares of our common stock, par value of $0.001 per share, and 5,000,000 shares of our preferred stock, par value $0.001 per share. As of May 28, 2026, 88,449,412 shares of our common stock were issued and outstanding, and no shares of our preferred stock were issued or outstanding.

Voting Rights

Except as otherwise required by Delaware law, at every annual or special meeting of stockholders, every holder of common stock is entitled to one vote for each share held of record on all matters to be voted upon by the stockholders. Directors are elected by plurality vote. Therefore, the holders of a majority of the common stock voted can elect all of the directors then standing for election. The common stock is not entitled to cumulative voting rights or preemptive rights and is not subject to conversion or redemption.

Dividend and Liquidation Rights

Subject to the rights, powers and preferences of any outstanding preferred stock, the holders of outstanding shares of common stock are entitled to receive dividends out of assets or funds legally available for the payment of dividends at such times and in such amounts as the Company's board of directors (the "Board of Directors") from time to time may determine. We have never paid any cash dividends on our common stock and do not anticipate paying any cash dividends on our common stock in the foreseeable future. We intend to retain future earnings to fund ongoing operations and future capital requirements. Any future determination to pay dividends will be at the discretion of the Board of Directors and will be dependent upon financial condition, results of operations, capital requirements and such other factors as the Board of Directors deems relevant.

In the event of our liquidation, dissolution or winding up, the holders of our common stock are entitled to receive pro rata our assets, which are legally available for distribution, after payments of all debts and other liabilities and if preferred stock shall then be outstanding subject to the prior rights of any outstanding preferred stock. The rights, preferences and privileges of holders of our common stock are subject to and may be adversely affected by the rights of the holders of shares of any series of our preferred stock that we may designate and issue in the future.

Preferred Stock

The Board of Directors, in the exercise of its discretion, is authorized to issue the undesignated preferred stock in one or more series, to determine the powers, preferences and rights, and qualifications, limitations or restrictions, granted to or imposed upon any wholly unissued series of undesignated preferred stock, and to fix the number of shares constituting any series and the designation of such series. These rights, preferences and privileges could include dividend rights, conversion rights, voting rights, terms of redemption, liquidation preferences and the number of shares constituting any series or the designation of such series, any or all of which may be greater than the rights of our common stock. The authorized shares of our preferred stock are available for issuance without further action by our stockholders, unless such action is required by applicable law or the rules of any stock exchange on which our securities may be listed. If the approval of our stockholders is not required for the issuance of shares of our preferred stock, our Board of Directors may determine not to seek stockholder approval. The specific terms of any series of preferred stock will be described in the applicable prospectus supplement and certificate of designation amending the certificate of incorporation.

Any issuance of our preferred stock, while providing flexibility in connection with possible acquisitions and other corporate purposes, could, among other things, adversely affect the voting power of holders of our common stock, and the likelihood that such holders would receive dividend payments and payments on liquidation, which might adversely affect the market price of our common stock. In addition, the issuance of preferred stock could have the effect of delaying, deferring or preventing a change of control or other corporate action. No shares of preferred stock are outstanding, and we have no current plan to issue any shares of preferred stock.

Listing on the NYSE American

Our shares of common stock are listed on the NYSE American under the symbol "MLSS."

Authorized but Unissued Common Stock

The DGCL does not require stockholder approval for any issuance of authorized shares, except in certain limited circumstances. However, the listing requirements of the NYSE American, which would apply for so long as our common stock is listed on the NYSE American, require stockholder approval of certain issuances (other than a public offering) equal to or exceeding 20% of the then outstanding voting power or then outstanding number of shares of common stock, as well as for certain issuances of stock in compensatory transactions. These additional shares may be used for a variety of corporate purposes, including future public offerings, to raise additional capital or to facilitate acquisitions. One of the effects of the existence of unissued and unreserved shares of common stock may be to enable our Board of Directors to sell shares to persons friendly to current management, for such consideration, in form and amount, as is acceptable to the Board, which issuance could render more difficult or discourage an attempt to obtain control of us by means of a merger, tender offer, proxy contest or otherwise, and thereby protect the continuity of our management and possibly deprive stockholders of opportunities to sell their common stock at prices higher than prevailing market prices.

Transfer Agent and Registrar

The transfer agent and registrar for our common stock is Continental Stock Transfer & Trust Company, 1 State Street, 30th Floor, New York, NY 10004.

CERTAIN PROVISIONS OF DELAWARE LAW AND OF THE
COMPANY'S CERTIFICATE OF INCORPORATION AND BY-LAWS

The following paragraphs regarding certain provisions of the DGCL, the Certificate of Incorporation, and the By-laws are summaries of the material terms thereof and do not purport to be complete. We urge you to read the prospectus, any related free writing prospectuses related to a security that we may offer under this prospectus, the DGCL, and the Certificate of Incorporation and By-laws. Copies of the Certificate of Incorporation and By-laws are on file with the SEC as exhibits to filings previously made by us. See "Where You Can Find More Information."

General

The provisions of the DGCL, and the Certificate of Incorporation and By-laws could have the effect of discouraging others from attempting an unsolicited offer to acquire our company. Such provisions may also have the effect of preventing changes in our management. It is possible that these provisions could make it more difficult to accomplish transactions that stockholders may otherwise deem to be in their best interests.

Effects of Authorized but Unissued Stock

One of the effects of the existence of authorized but unissued common stock or preferred stock may be to enable our board of directors to make more difficult or to discourage an attempt to obtain control of our Company by means of a merger, tender offer, proxy contest or otherwise, and thereby to protect the continuity of management. If, in the due exercise of its fiduciary obligations, the board of directors were to determine that a takeover proposal was not in our best interest, such shares could be issued by the board of directors without stockholder approval in one or more transactions that might prevent or render more difficult or costly the completion of the takeover transaction by diluting the voting or other rights of the proposed acquirer or insurgent stockholder group, by putting a substantial voting block in institutional or other hands that might undertake to support the position of the incumbent board of directors, by effecting an acquisition that might complicate or preclude the takeover, or otherwise.

Undesignated Preferred Stock

Our board of directors has the ability to issue preferred stock with voting or other rights, preferences and privileges that could have the effect of deterring hostile takeovers or delaying changes in control of our Company or management.

Cumulative Voting

Our Certificate of Incorporation does not provide for cumulative voting in the election of directors, which would allow holders of less than a majority of the stock to elect some directors.

Classified Board of Directors

Our Certificate of Incorporation and By-laws do not provide for a classified board of directors.

Vacancies

Our By-laws provide that all vacancies may be filled by the affirmative vote of a majority of directors then in office, even if less than a quorum.

Actions at Meetings of Stockholders; Special Meeting of Stockholders and Advance Notice Requirements for Stockholder Proposals

Our Certificate of Incorporation and By-laws require that any action required or permitted to be taken by our stockholders must be effected at a duly called annual or special meeting of the stockholders or by a consent in writing. Our By-laws also provide that special meetings of stockholders may be called from time to time only by a majority of our board of directors. The inability of stockholders to call special meetings may limit the ability of stockholders to approve transactions that they may deem to be in their best interests.

For a nomination or proposal to be properly brought before an annual meeting by a stockholder, the stockholder must have given timely notice thereof in writing to the Secretary of the Company. To be timely, such stockholder's notice must be delivered to, or mailed to and received at, the principal executive offices of the Company not less than thirty (30) days and not more than sixty (60) days prior to the scheduled annual meeting, regardless of any postponements, deferrals or adjournments of that meeting to a later date; provided, however, that if less than forty (40) days' notice or prior public disclosure of the date of the scheduled annual meeting is given or made, notice by the stockholder, to be timely, must be so delivered or received not later than the close of business on the tenth (10th) day following the earlier of the day on which such notice of the date of the scheduled annual meeting was mailed or the day on which such public disclosure was made. A stockholder's notice to the Secretary shall set forth the information required pursuant to the By-laws. These provisions may have the effect of deterring unsolicited offers to acquire our company or delaying stockholder actions, even if they are favored by the holders of a majority of our outstanding voting securities.

Effect of Delaware Anti-Takeover Statute

We are subject to Section 203 of the Delaware General Corporation Law, an anti-takeover law. In general, Section 203 prohibits a Delaware corporation from engaging in any business combination (as defined below) with any interested stockholder (as defined below) for a period of three years following the date that the stockholder became an interested stockholder, unless:

● prior to that date, the board of directors of the corporation approved either the business combination or the transaction that resulted in the stockholder becoming an interested stockholder;

● upon consummation of the transaction that resulted in the stockholder becoming an interested stockholder, the interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for purposes of determining the number of shares of voting stock outstanding (but not the voting stock owned by the interested stockholder) those shares owned (i) by persons who are directors and officers and (ii) employee stock plans in which employee participants do not have the right to determine whether shares held subject to the plan will be tendered in a tender or exchange offer; or

● at or subsequent to that date, the business combination is approved by the board of directors of the corporation and authorized at an annual or special meeting of stockholders, and not by written consent, by the affirmative vote of at least 66 2/3% of the outstanding voting stock that is not owned by the interested stockholder.

In general, Section 203 defines an interested stockholder as any entity or person beneficially owning 15% or more of the outstanding voting stock of the corporation, or who beneficially owns 15% or more of the outstanding voting stock of the corporation at any time within a three-year period immediately prior to the date of determining whether such person is an interested stockholder, and any entity or person affiliated with or controlling or controlled by any of these entities or persons.

Under certain circumstances, this provision could make it more difficult for a person who would be an "interested stockholder" to effect various business combinations with a corporation for a three-year period.

SELLING STOCKHOLDERS

The shares of common stock being offered by the selling stockholders, consisting of Initial Shares and Warrant Shares underlying the Warrants, in each case were issued to the selling stockholders pursuant to the Purchase Agreement and are being registered hereby to fulfill our contractual obligations under the Registration Rights Agreement. For additional information regarding the issuances of the Initial Shares and Warrants, see "PROSPECTUS SUMMARY - Private Placement." We are registering the shares of common stock in order to permit the selling stockholders to offer the shares for resale from time to time.

Except for the ownership of the shares of common stock and the warrants acquired in the Private Placement and except as set forth in the footnotes to the table below, the selling stockholders have not had any material relationship with us within the past three years. For additional information regarding the issuances of the Initial Shares and Warrants to certain directors and officers, see "PROSPECTUS SUMMARY - Private Placement."

The 15,925,963 Shares being registered for resale by the participating selling stockholders under the registration statement of which this prospectus is a part, as required by the Registration Rights Agreement, reflects the number of Shares that the participating selling stockholders reported to the Company as being beneficially owned by them in Selling Stockholder Notices and Questionnaires and supplementary communications as of May 28, 2026 (the "Determination Date"), the most recent practicable date on which such selling stockholders provided security ownership information to the Company prior to the filing of the registration statement of which this prospectus is a part. The number of Shares reflects any sale, disposition or transfer of Shares by such selling stockholders in transactions exempt from the registration requirements of the Securities Act on or prior to such date.

The table below sets forth the number and percentage of shares of our common stock beneficially owned by the selling stockholders as of their Determination Date, taking into account the number of shares that may be offered under this prospectus and the number and percentage of our common stock beneficially owned by the selling stockholders assuming all of the shares offered under this prospectus are sold.

The second column lists the number of shares of common stock owned by the selling stockholders prior to the offering under this prospectus. For this purpose, the shares issuable upon exercise of the Warrants are not included since the Warrants are not exercisable within 60 days of the Determination Date. The third column, entitled "Maximum Number of Shares of Common Stock Offered", represents all of the shares of our common stock that the selling stockholders may offer under this prospectus. The column entitled "Number of Shares of Common Stock Owned After Offering" assumes the sale of all of the shares of our common stock offered by the selling stockholders under this prospectus and that the selling stockholders do not acquire any additional shares of our common stock before the completion of the offering under this prospectus. However, because the selling stockholders may sell all or some of the shares offered under this prospectus from time to time, or in another permitted manner, we cannot assure you as to the actual number of shares of our common stock that will be sold by the selling stockholders or that will be held by the selling stockholders after completion of any sales. The selling stockholders may sell some, all or none of the shares of our common stock offered under this prospectus. We do not know how long the selling stockholders will hold the Initial Shares or Warrants, whether any selling stockholders will exercise the Warrants, and upon such exercise, how long such selling stockholders will hold the shares of common stock before selling them, and we currently have no agreements, arrangements or understandings with the selling stockholders regarding the sale of any of the shares of common stock, other than selling stockholders who are (or immediate family members of) directors or officers of the Company with respect to the Lock-Up Agreements described in "PROSPECTUS SUMMARY - Private Placement."

In accordance with the terms of the Registration Rights Agreement with the selling stockholders, this prospectus generally covers the resale of the sum of (i) the number of shares of common stock issued to the selling stockholders in the "Private Placement" described above (the Initial Shares) and (ii) the maximum number of shares of common stock issuable upon exercise of the related warrants (the Warrant Shares), determined as if the outstanding warrants were exercised in full as of the trading day immediately preceding the date this registration statement was initially filed with the SEC, without regard to any limitations on the exercise of the warrants. The fourth column assumes the sale of all of the shares offered by the selling stockholders pursuant to this prospectus, including Warrant Shares with respect to unexercised Warrants.

Beneficial ownership is determined in accordance with the rules of the SEC and includes voting or investment power with respect to shares of our common stock. Generally, a person "beneficially owns" shares of our common stock if the person has or shares with others the right to vote those shares or to dispose of them, or if the person has the right to acquire voting or disposition rights within sixty (60) days. Such shares, however, are not deemed outstanding for the purposes of computing the percentage ownership of any other person. Shares of common stock that are not issuable prior to obtaining stockholder approval are not included in the beneficial ownership amounts as of the Determination Date. The Company intends to seek stockholder approval of the issuance of these shares at its 2026 Annual Meeting of Stockholders scheduled for July 27, 2026.

All information contained in the table below and the footnotes thereto is based upon information provided to us by the selling stockholders. The percentage of shares of our common stock owned is based on 88,449,412 shares of our common stock issued and outstanding as of May 28, 2026. Unless otherwise indicated in the footnotes to this table, we believe that the selling stockholders have sole voting and investment power with respect to the shares of our common stock indicated as beneficially owned.

As used in this prospectus, the term "selling stockholders" includes the selling stockholders named below and any donees, pledgees, transferees or other successors-in-interest selling shares of our common stock received after the date of this prospectus from the selling stockholders as a gift, pledge, or other non-sale related transfer.

Under the terms of the warrants, a selling stockholder may not exercise any such warrants to the extent such exercise would cause (i) such selling stockholder, together with its affiliates and attribution parties, to beneficially own a number of shares of common stock which would exceed 4.99% or 9.99%, as applicable, of our then outstanding common stock following such exercise, after giving effect to the issuance of shares of Common Stock issuable upon exercise of the Warrant, or (ii) the aggregate number of shares of common stock which the Company may issue (A) pursuant to the terms of the Purchase Agreement and (B) upon exercise of all of the warrants to violate the rules or regulations of the NYSE American. The number of shares in the fourth column do not reflect this limitation. The selling stockholders may sell all, some or none of their shares in this offering. See "Plan of Distribution."

Name of Selling Stockholder		Number of shares of Common Stock Owned Prior to Offering				Maximum Number of Shares of Common Stock Offered Pursuant to this Prospectus				Number of Shares of Common Stock Owned After Offering				Percent of Common Stock Owned After Offering
Raminder Singh Taneja (1)			627,685				370,370				442,500				*
Thomas Barrett (2)			748,148				1,496,296				-				*
Connor Jones (3)			245,006				185,185				152,413				*
Donald William Watros (4)			185,185				370,370				-				*
Alon Gibli (5)			691,344				222,222				580,233				*
Bruce Healy (6)			370,371				740,741				-				*
Eric Hines (7)			1,760,185				370,370				1,575,000				1.76	%
Marshall Jones (8)			1,051,371				740,741				681,000				*
Patrick Metcalf (9)			1,503,334				1,666,667				670,000				*
Richard Molinsky (10)			897,851				555,556				620,073				*
Prudential LLC (11)			141,196				185,185				48,603				*
Eric Samuelson (12)			92,593				185,185				-				*
Stephen Schaerfer (13)			598,132				555,556				320,354				*
Michael and Jill Solomon (14)			663,067				555,556				385,289				*
Steven Widner (15)			798,148				296,296				650,000				*
Stanton Jones (16)			2,390,854				3,533,333				624,187				*
Stanton Jones, Jr. (17)			205,389				185,184				112,797				*
BQ278 LLC (18)			370,371				740,741				-				*
Neal Goldman (19)			4,171,938				1,995,371				3,174,252				3.56	%
Benedetta Casamento (20)			1,194,606				650,000				869,606				*
Dr. Dider Demesmin (21)			602,111				325,000				439,611				*
Total			19,308,881				15,925,926				11,345,918				*

* Less than one percent.

(1) The number of shares of common stock listed in the third column of the table above consists of 185,185 Initial Shares and 185,185 Warrant Shares issuable upon exercise of Warrants issued to Mr. Taneja in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(2) The number of shares of common stock listed in the third column of the table above consists of 748,148 Initial Shares and 748,148 Warrant Shares issuable upon exercise of Warrants issued to Mr. Barrett in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(3) The number of shares of common stock listed in the third column of the table above consists of 92,593 Initial Shares and 92,953 Warrant Shares issuable upon exercise of Warrants issued to Mr. Jones in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities. Mr. Jones is the brother of Stanton Jones, Jr, the son of Stanton Jones and nephew of Marshall Jones.

(4) Mr. Watros is the husband of Benedetta Casamento, the Chairman of the Board of the Company. In connection with, and as a condition to closing, the Private Placement, Ms. Casamento entered into a Lock-Up Agreement restricting transfers of the Company's securities owned by her until April 2027, subject to certain exceptions, and Mr. Watros entered into the same Lock-Up Agreement in connection with this offering. The number of shares of common stock listed in the third column of the table above consists of 185,185 Initial Shares and 185,185 Warrant Shares issuable upon exercise of Warrants issued to Mr. Watros in the Private Placement. Mr. Watros disclaims beneficial ownership of shares owned or offered by his wife, Ms. Casamento. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over his securities.

(5) The number of shares of common stock listed in the third column of the table above consists of 111,111 Initial Shares and 111,111 Warrant Shares issuable upon exercise of Warrants issued to Mr. Gibli in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(6) The number of shares of common stock listed in the third column of the table above consists of 370,370 Initial Shares and 370,370 Warrant Shares issuable upon exercise of Warrants issued to Mr. Healy in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(7) Mr. Hines is and since August 2025 has been the President, Chief Executive Officer and a member of the Board of Directors of the Company. In connection with, and as a condition to closing, the Private Placement, Mr. Hines entered into a Lock-Up Agreement restricting transfers of the Company's securities owned by him and his affiliates until April 2027, subject to certain exceptions. Mr. Hines is also a party to the other agreements entered into by each of the purchasers in the Private Placement. See the section of this prospectus entitled, "PROSPECTUS SUMMARY - Private Placement." The Company and Mr. Hines are parties to an Employment Agreement described in, and an exhibit to, our Annual Report on Form 10-K for our most recent fiscal year. The number of shares of common stock listed in the second and fourth columns of the table above includes 325,000 shares held by Mr. Hines prior to joining the Company, 1,250,000 shares issuable upon the exercise of stock options vested or vesting within 60 days of the date hereof. The number of shares of common stock listed in the third column of the table above consists of 185,185 Initial Shares and 185,185 Warrant Shares issuable upon exercise of Warrants issued to Mr. Hines in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(8) The number of shares of common stock listed in the third column of the table above consists of 370,370 Initial Shares and 370,370 Warrant Shares issuable upon exercise of Warrants issued to Mr. Jones in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities. Mr. Jones is the brother of Stanton Jones, and the uncle of Connor Jones and Stanton Jones, Jr.

(9) The number of shares of common stock listed in the third column of the table above consists of 833,333 Initial Shares and 833,333 Warrant Shares issuable upon exercise of Warrants issued to Mr. Metcalf in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(10) The number of shares of common stock listed in the third column of the table above consists of 277,778 Initial Shares and 277,778 Warrant Shares issuable upon exercise of Warrants issued to Mr. Molinsky in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(11) The number of shares of common stock listed in the third column of the table above consists of 92,593 Initial Shares and 92,593 Warrant Shares issuable upon exercise of Warrants issued to such stockholder in the Private Placement. Prudential LLC has advised us that William Davis and James Pappas, each a natural person, each holds 50% of Prudential LLC and voting and/or investment control over the securities.

(12) The number of shares of common stock listed in the third column of the table above consists of 92,953 Initial Shares and 92,953 Warrant Shares issuable upon exercise of Warrants issued to Mr. Samuelson in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(13) The number of shares of common stock listed in the third column of the table above consists of 277,778 Initial Shares and 277,778 Warrant Shares issuable upon exercise of Warrants issued to Mr. Schaerfer in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(14) The number of shares of common stock listed in the third column of the table above consists of 277,778 Initial Shares and 277,778 Warrant Shares issuable upon exercise of Warrants issued to Michael and Jill Solomon in the Private Placement. They are natural persons who have advised us that they hold sole or shared voting and/or investment control over the securities.

(15) The number of shares of common stock listed in the third column of the table above consists of 148,148 Initial Shares and 148,148 Warrant Shares issuable upon exercise of Warrants issued to Mr. Widner in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(16) The number of shares of common stock listed in the third column of the table above consists of 1,766,667 Initial Shares and 1,766,667 Warrant Shares issuable upon exercise of Warrants issued to Mr. Jones in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities. Mr. Jones is the father of Connor Jones and Stanton Jones, Jr., and the brother of Marshall Jones.

(17) The number of shares of common stock listed in the third column of the table above consists of 92,592 Initial Shares and 92,592 Warrant Shares issuable upon exercise of Warrants issued to Mr. Jones, Jr. in the Private Placement. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities. Mr. Jones, Jr. is the brother of Connor Jones, the son of Stanton Jones and the nephew of Marshall Jones.

(18) The number of shares of common stock listed in the third column of the table above consists of 370,370 Initial Shares and 370,370 Warrant Shares issuable upon exercise of Warrants issued to such stockholder in the Private Placement. BQ278 LLC has advised us that Joshua Scherer and Steven Seremitis, each a natural person, each holds 50% of BQ278 LLC and voting and/or investment control over the securities.

(19) Mr. Goldman has been a member of the Board of Directors of the Company since 2019 and has served as Chairman of the Board from 2023 until 2025. In connection with, and as a condition to closing, the Private Placement, Mr. Goldman entered into a Lock-Up Agreement restricting transfers of the Company's securities owned by him and his affiliates until April 2027, subject to certain exceptions. Mr. Goldman is also a party to the other agreements entered into by each of the purchasers in the Private Placement. In April 2025, Mr. Goldman purchased $500,000 of Convertible Bridge Notes of the Company, of which $208,761 of principal and $10,614 of interest was applied as consideration in the Private Placement and the balance of his Convertible Bridge Note remains outstanding. See the section of this prospectus entitled, "PROSPECTUS SUMMARY - Private Placement." The number of shares of common stock listed in the second and fourth columns of the table above includes 613,547 shares issuable upon conversion of the unconverted principal and accrued interest on his Convertible Bridge Note at a conversion price of $0.50 per share. The number of shares of common stock listed in the third column of the table above consists of (i) 185,185 Initial Shares and 185,185 Warrant Shares issuable upon exercise of Warrants issued to Mr. Goldman in the Private Placement for cash, and (ii) 812,501 Initial Shares and 812,501 Warrant Shares issuable upon exercise of Warrants issued to Mr. Goldman in the Private Placement upon conversion of his Convertible Bridge Note, for an aggregate of 997,686 Initial Shares and 997,686 Warrant Shares, or an aggregate of 1,995,371 Shares. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

(20) Ms. Casamento has been a member of the Board of Directors of the Company since 2022 and has served as Chairman of the Board of Directors of the Company since December 2025. She is the wife of Mr. Watros, also a selling stockholder. In connection with, and as a condition to closing, the Private Placement, Ms. Casamento entered into a Lock-Up Agreement restricting transfers of the Company's securities owned by her until April 2027, subject to certain exceptions. Ms. Casamento is also a party to the other agreements entered into by each of the purchasers in the Private Placement. In April 2025, Ms. Casamento purchased $200,000 of Convertible Bridge Notes of the Company, of which $83,504 of principal and $4,246 of interest was applied as consideration in the Private Placement and the balance of her Convertible Bridge Note remains outstanding. See the section of this prospectus entitled, "PROSPECTUS SUMMARY - Private Placement." The number of shares of common stock listed in the second and fourth columns of the table above includes 245,419 shares issuable upon conversion of the unconverted principal and accrued interest on her Convertible Bridge Note at a conversion price of $0.50 per share. The number of shares of common stock listed in the third column of the table above consists of 325,000 Initial Shares and 325,000 Warrant Shares issuable upon exercise of Warrants issued to Ms. Casamento in the Private Placement upon conversion of her Convertible Bridge Note, or an aggregate of 650,000 Shares. Ms. Casamento disclaims beneficial ownership of shares owned or offered by her husband, Mr. Watros. She is a natural person who has advised us that she holds sole or shared voting and/or investment control over her securities.

(21) Dr. Demesmin has been a member of the Board of Directors of the Company since 2024. In connection with, and as a condition to closing, the Private Placement, Dr. Demesmin entered into a Lock-Up Agreement restricting transfers of the Company's securities owned by him and his affiliates until April 2027, subject to certain exceptions. Dr. Demesmin is also a party to the other agreements entered into by each of the purchasers in the Private Placement. In April 2025, Dr. Demesmin purchased $100,000 of Convertible Bridge Notes of the Company, of which $41,752 of principal and $2,123 of interest was applied as consideration in the Private Placement and the balance of his Convertible Bridge Note remains outstanding. See the section of this prospectus entitled, "PROSPECTUS SUMMARY - Private Placement." The number of shares of common stock listed in the second and fourth columns of the table above includes 122,710 shares issuable upon conversion of the unconverted principal and accrued interest on his Convertible Bridge Note at a conversion price of $0.50 per share. The number of shares of common stock listed in the third column of the table above consists of 162,500 Initial Shares and 162,500 Warrant Shares issuable upon exercise of Warrants issued to Dr. Demesmin in the Private Placement upon conversion of his Convertible Bridge Note, or an aggregate of 325,000 Shares. He is a natural person who has advised us that he holds sole or shared voting and/or investment control over the securities.

PLAN OF DISTRIBUTION

Each selling stockholder of the securities and any of their pledgees, assignees and successors-in-interest may, from time to time, sell any or all of their securities covered hereby on the NYSE American or any other stock exchange, market or trading facility on which the securities are traded or in private transactions. These sales may be at fixed or negotiated prices. A selling stockholder may use any one or more of the following methods when selling securities:

	●	ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;
	●	block trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block as principal to facilitate the transaction;
	●	purchases by a broker-dealer as principal and resale by the broker-dealer for its account;
	●	an exchange distribution in accordance with the rules of the applicable exchange;
	●	privately negotiated transactions;
	●	settlement of short sales;
	●	in transactions through broker-dealers that agree with the selling stockholders to sell a specified number of such securities at a stipulated price per security;
	●	through the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise;
	●	a combination of any such methods of sale; or
	●	any other method permitted pursuant to applicable law.

The selling stockholders may also sell securities under Rule 144 or any other exemption from registration under the Securities Act of 1933, as amended (the "Securities Act"), if available, rather than under this prospectus.

Broker-dealers engaged by the selling stockholders may arrange for other broker-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the selling stockholders (or, if any broker-dealer acts as agent for the purchaser of securities, from the purchaser) in amounts to be negotiated, but, except as set forth in a supplement to this Prospectus, in the case of an agency transaction not in excess of a customary brokerage commission in compliance with FINRA Rule 2121; and in the case of a principal transaction a markup or markdown in compliance with FINRA Rule 2121.

In connection with the sale of the securities or interests therein, the selling stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the securities in the course of hedging the positions they assume. The selling stockholders may also sell securities short and deliver these securities to close out their short positions, or loan or pledge the securities to broker-dealers that in turn may sell these securities. The selling stockholders may also enter into option or other transactions with broker-dealers or other financial institutions or create one or more derivative securities which require the delivery to such broker-dealer or other financial institution of securities offered by this prospectus, which securities such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction).

The selling stockholders and any broker-dealers or agents that are involved in selling the securities may be deemed to be "underwriters" within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the securities purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. Each selling stockholder has informed the Company that it does not have any written or oral agreement or understanding, directly or indirectly, with any person to distribute the securities.

The Company is required to pay certain fees and expenses incurred by the Company incident to the registration of the securities. The Company has agreed to indemnify the selling stockholders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act.

We agreed to keep this prospectus effective until the earlier of (i) the date on which the securities may be resold by the selling stockholders without registration and without regard to any volume or manner-of-sale limitations by reason of Rule 144, without the requirement for the Company to be in compliance with the current public information under Rule 144 under the Securities Act or any other rule of similar effect or (ii) all of the securities have been sold pursuant to this prospectus or Rule 144 under the Securities Act or any other rule of similar effect. The resale securities will be sold only through registered or licensed brokers or dealers if required under applicable state securities laws. In addition, in certain states, the resale securities covered hereby may not be sold unless they have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and is complied with.

Under applicable rules and regulations under the Exchange Act, any person engaged in the distribution of the resale securities may not simultaneously engage in market making activities with respect to the common stock for the applicable restricted period, as defined in Regulation M, prior to the commencement of the distribution. In addition, the selling stockholders will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of the common stock by the selling stockholders or any other person. We will make copies of this prospectus available to the selling stockholders and have informed them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale (including by compliance with Rule 172 under the Securities Act).

LEGAL MATTERS

The validity and legality of the securities offered hereby and certain other legal matters will be passed upon for the Company by Tarter Krinsky & Drogin LLP, New York, New York.

EXPERTS

The consolidated financial statements of the Company incorporated in this prospectus by reference from the Annual Report on Form 10-K of the Company for the year ended December 31, 2025 have been audited by CBIZ CPAs P.C. ("CBIZ CPAs"), an independent registered public accounting firm, as stated in their report (which report expresses an unqualified opinion and includes an explanatory paragraph relating to a going concern uncertainty). Such consolidated financial statements have been so incorporated by reference in reliance upon the report of such firm given their authority as experts in accounting and auditing.

The consolidated financial statements of the Company incorporated in this prospectus by reference from the Annual Report on Form 10-K of the Company for the year ended December 31, 2024 have been audited by Marcum LLP ("Marcum"), an independent registered public accounting firm, as stated in their report. Such consolidated financial statements have been so incorporated by reference in reliance upon the report of such firm given their authority as experts in accounting and auditing.

Changes in Registrant's Certifying Accountant.

As previously reported by the Company in its current report on Form 8-K filed April 22, 2025, on November 1, 2024, CBIZ CPAs acquired the attest business of Marcum, effective November 1, 2024, and Marcum continued to serve as the Company's independent registered public accounting firm through April 22, 2025, subsequent to the filing of the Annual Report of the Company on Form 10-K containing the audited consolidated financial statements of the Company for the fiscal year ended December 31, 2024. On April 22, 2025, Marcum resigned as the Company's independent registered public accounting firm and, with the approval of the Audit Committee of the Board of Directors of the Company, CBIZ CPAs was engaged as the Company's independent registered public accounting firm for the fiscal year ended December 31, 2025.

As previously reported by the Company in its current report on Form 8-K filed May 6, 2026, on April 30, 2026, the Board of Directors of Company approved the dismissal of CBIZ CPAs P.C. ("CBIZ CPAs") as the independent registered public accounting firm to the Company effective as of May 15, 2026 (after the filing by the Company of its quarterly report on Form 10-Q for the quarter ended March 31, 2026), and the Company entered into an engagement agreement with Grassi & Co. Certified Public Accountants, PC ("Grassi"), as its new independent registered public accounting firm effective May 15, 2026. Grassi did not audit the Company's financial statements for the year ended December 31, 2025 or the quarter ended March 31, 2026.

WHERE YOU CAN FIND MORE INFORMATION

We file annual reports, quarterly reports, current reports, proxy statements and other information with the SEC under the Exchange Act. You can read our SEC filings, including the registration statement, at the SEC's website at www.sec.gov, which contains reports, proxy and information statements and other information regarding issuers that file electronically with the SEC. Our website is located at www.milestonescientific.com. The information contained on, or that may be obtained from, our website is not, and shall not be deemed to be, a part of this prospectus.

We will provide, upon written or oral request, without charge to you, including any beneficial owner to whom this prospectus is delivered, a copy of any or all of the documents incorporated herein by reference other than the exhibits to those documents, unless the exhibits are specifically incorporated by reference into the information that this prospectus incorporates. You should direct a request for copies to Milestone Scientific at 425 Eagle Rock Ave., Ste 403, Roseland, NJ 07068; Attention: Keisha Harcum; telephone number (973) 535-2717.

INCORPORATION BY REFERENCE

The SEC permits us to "incorporate by reference" the information and reports we file with it. This means that we can disclose important information to you by referring to another document. The information that we incorporate by reference is considered to be part of this prospectus, and later information that we file with the SEC automatically updates and supersedes this information. We incorporate by reference the documents listed below, except to the extent information in those documents is different from the information contained in this prospectus, and all future documents filed with the SEC under Sections 13(a), 13(c), 14, or 15(d) of the Exchange Act until we terminate the offering of these securities:

● Our Annual Report on Form 10-K for the year ended December 31, 2025, which was filed on March 31, 2026 (as amended by Form 10-K/A filed May 5, 2026);

● Our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2026, which was filed on May 13, 2026;

● Our Current Reports on Form 8-K filed April 2, 2026, April 21, 2026, May 6, 2026 and May 6, 2026;

● The information contained in our definitive proxy statement on Schedule 14A for our 2025 annual meeting of stockholders filed with the SEC on November 12, 2025, to the extent incorporated by reference in Part III of the Form 10-K; and

● The description of the Registrant's common stock contained in the Registrant's Registration Statement on Form 8-A, originally filed with the SEC pursuant to Section 12(b) of the Exchange Act on May 28, 2015, including any further amendment or report filed hereafter for the purpose of updating such description.

All reports and other documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date hereof, and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be part hereof from the date of filing of such reports and documents.

Any statement contained herein or in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated herein by reference modifies or supersedes such earlier statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

We will furnish without charge to you, on written or oral request, a copy of any or all of the documents incorporated by reference, including exhibits to these documents. You should direct any requests for documents to:

Milestone Scientific Inc.

425 Eagle Rock Road, Ste 403

Roseland, NJ 07068

Attention: Keisha Harcum

Telephone: (973) 535-2717

We have authorized no one to provide you with any information that differs from that contained in this prospectus. Accordingly, you should not rely on any information that is not contained or incorporated by reference in this prospectus. You should not assume that the information in this prospectus is accurate as of any date other than the date of the front cover of this prospectus.

Our reports and documents incorporated by reference herein may also be found in the "Investors" section of our website at https://www.milestonescientific.com/investors/sec-filings/all-sec-filings. The content of our website and any information that is linked to or accessible from our website (other than our filings with the SEC that are incorporated by reference, as set forth under "Incorporation by Reference") is not incorporated by reference into this prospectus or any applicable prospectus supplement and you should not consider it a part of this prospectus, any applicable prospectus supplement, or the registration statement.

Up to 15,925,926 Shares of Common Stock Offered by the Selling Stockholders

PROSPECTUS

June 2, 2026

We have not authorized any dealer, salesperson or other person to give any information or represent anything not contained in this prospectus. You must not rely on any unauthorized information. If anyone provides you with different or inconsistent information, you should not rely on it. This prospectus does not offer to sell any securities in any jurisdiction where it is unlawful. Neither the delivery of this prospectus, nor any sale made hereunder, shall create any implication that the information in this prospectus is correct after the date hereof.

PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution.

The following is an itemized statement of expenses of the Company in connection with the issuance and delivery of the securities being registered hereby, other than underwriting discounts and commissions.

SEC Registration Fee		$	792
Accounting Fees and Expenses		$	25,000
Legal Fees and Expenses		$	65,000
Miscellaneous		$	4,208
Total		$	95,000

Item 15. Indemnification of Directors and Officers.

We are incorporated under the laws of the State of Delaware. Section 102(b)(7) of the DGCL allows a corporation to provide in its certificate of incorporation that a director of the corporation will not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except where the director breached the duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained an improper personal benefit. The Company's Certificate of Incorporation provides for this limitation of liability.

Section 145 of the DGCL, or Section 145, provides that a Delaware corporation may indemnify any person who was, is or is threatened to be made, party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent of such corporation or is or was serving at the request of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, provided such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation's best interests and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal. A Delaware corporation may indemnify any persons who were or are a party to any threatened, pending or completed action or suit by or in the right of the corporation by reason of the fact that such person is or was a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees) actually and reasonably incurred by such person in connection with the defense or settlement of such action or suit, provided such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation's best interests, provided that no indemnification is permitted without judicial approval if the officer, director, employee or agent is adjudged to be liable to the corporation. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him against the expenses which such officer or director has actually and reasonably incurred.

Section 145 further authorizes a corporation to purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation or enterprise, against any liability asserted against him and incurred by him in any such capacity, or arising out of his or her status as such, whether or not the corporation would otherwise have the power to indemnify him under Section 145.

The Company's Certificate of Incorporation provides that the liability of directors for monetary damages shall be eliminated to the fullest extent authorized by the DGCL. The Company's By-laws state that the Company shall indemnify every director or officer of the Company for all liabilities, costs and expenses incurred in connection with such directorship or office and any actions taken or omitted in such capacity to the greatest extent permitted under the DGCL and other applicable laws at the time of such indemnification, reimbursement or advance payment.

Expenses incurred by any present or former director or officer of the Company in defending any civil, criminal, administrative, or investigative action, suit, or proceeding, shall be paid by the Company in advance of the final disposition of such action, suit, or proceeding upon receipt of an undertaking in writing by or on behalf of such person to repay such amount if it shall ultimately be determined that such person is not entitled to indemnification.

Other than discussed above, neither the Company's By-laws nor its Certificate of Incorporation includes any specific indemnification provisions for the Company's officers or directors against liability under the Securities Act. The Company has also purchased insurance providing for indemnification of its directors and officers. Additionally, insofar as

indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Company pursuant to the foregoing provisions, or otherwise, the Company has been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.

Item 16. Exhibits.

EXHIBIT INDEX

Exhibit Number		Description
3.1		Restated Certificate of Incorporation of the Registrant as amended (incorporated by reference to Exhibit 3.1 to the Company's Annual Report on Form 10-K filed on March 31, 2026, as amended).
3.2		Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.4 to the Company's Current Report on Form 10-K filed on April 1, 2019).
4.1		Specimen Certificate representing shares of common stock of the Registrant (incorporated by reference to Amendment No. 1 to the Company's Registration Statement on Form 10-KSB for the year ended May 15, 1995).
4.3		Form of Warrant (incorporated by reference to Exhibit 4.1 to the Company's Current Report on Form 8-K filed on April 21, 2026).
10.1		Form of Securities Purchase Agreement, dated April 20, 2026 (incorporated by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K filed on April 21, 2026).
10.2		Form of Registration Rights Agreement (incorporated by reference to Exhibit 10.2 to the Company's Current Report on Form 8-K filed on April 21, 2026).
10.3		Form of Lock-up Agreement (incorporated by reference to Exhibit 10.3 to the Company's Current Report on Form 8-K filed on April 21, 2026).
10.4		Form of Omnibus Signature Page (incorporated by reference to Exhibit 10.5 to the Company's Current Report on Form 8-K filed on April 21, 2026).
5.1		Opinion of Tarter Krinsky & Drogin LLP (filed herewith).
23.1		Consent of CBIZ CPAs P.C., independent registered public accounting firm (filed herewith).
23.2		Consent of Marcum LLP, independent registered public accounting firm (filed herewith).
23.3		Consent of Tarter Krinsky & Drogin LLP (contained in Exhibit 5.1 to the registration statement and filed herewith).
24.1		Power of attorney (set forth on the signature page of this registration statement).
107		Filing Fee Table (filed herewith).

Item 17. Undertakings.

(a) The undersigned Registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933, as amended (the "Securities Act");

(ii) To reflect in the prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this registration statement. Notwithstanding the foregoing, any increase or decrease in the volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Securities and Exchange Commission (the "SEC"), pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement; and

(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in this registration statement;

(2) provided, however, that paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the SEC by this registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") that are incorporated by reference in this registration statement, or, as to a registration statement on Form S-3, Form SF-3 or Form F-3, is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of this registration statement.

(b) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at the time shall be deemed to be the initial bona fide offering thereof.

(c) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(d) That, for the purpose of determining liability under the Securities Act to any purchaser:

(1) each prospectus filed by the Registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and

(2) each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof; provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date.

(e) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(f) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the indemnification provisions described herein, or otherwise, the Registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Borough of Roseland, State of New Jersey, on this 2nd day of June, 2026.

	Milestone Scientific Inc.
	/s/ Eric Hines
	Eric Hines
	Chief Executive Officer
	(Principal Executive Officer) and Director

	Milestone Scientific Inc.
	/s/ Keisha Harcum
	Keisha Harcum
	Vice President of Finance
	(Principal Accounting Officer)

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Benedetta Casamento and Eric Hines, or any of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and re-substitution, for such person and in his or her name, place and stead, in any and all capacities, to sign any or all amendments (including all pre-effective and post-effective amendments, exhibits thereto and other documents in connection therewith) to this registration statement and any subsequent registration statement filed by the registrant pursuant to Rule 462(b) and to file the same, with all exhibits thereto, and other documents in connection therewith, with the SEC, granting unto said attorneys-in-fact and agents or any one of them full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully as to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents, or any of them, or his or her substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated on June 2, 2026.

Signature		Title
/s/ Eric Hines		Chief Executive Officer
Eric Hines		(Principal Executive Officer) and Director
/s/ Keisha Harcum		Vice President of Finance
Keisha Harcum		(Principal Accounting Officer)
/s/Benedetta Casamento		Chairman of the Board
Benedetta Casamento
/s/ Neal Goldman		Director
Neal Goldman
/s/ Shanth Thiyagalingam		Director
Shanth Thiyagalingam
/s/ Dr. Didier Dememin		Director
Dr. Didier Demesmin
/s/ Dr. Dawood Sayed		Director
Dr. Dawood Sayed