Material Agreement (Form 8-K)

Item 1.01 - Entry into a Material Agreement

On January 15, 2026, Milestone Scientific Inc. ("the Company") entered into an Amended and Restated Memorandum of Understanding (the "MOU") with Innovest S.p.A., as the holder of certain consent/blockage rights with respect to BP4 S.r.l., a society' a responsibility' limitation in liquidation ("BP4"). According to BP4, it was then the owner of 11.31% of the outstanding shares of common stock of the Company. BP4 agreed, among other things, subject to certain conditions, including approval by its shareholders, not to sell or transfer any of its shares of the Company for a period of twelve months (the "Lock-Up" and such a period, the "Lock-Up Period") following consummation of a $2.5 million offering by the Company. The BP4 Lock-Up, in addition to customary underwriter exceptions, permits transfers of Lock-Up securities prior to the 12-month Lock-Up Period terminating, as follows:

● If the Company's stock closes above $0.50 for 10 consecutive trading days, then BP4 may distribute to its shareholders up to 33.33% of the Lock-Up securities; and

● If the Company's stock closes above $0.70 for 10 consecutive trading days, then BP4 may distribute to its shareholders up to an additional 33.3% of the Lock-Up securities (or up to 66.66% of the Lock-Up securities on a cumulative basis); and

● If the Company's stock closes above $0.90 for 10 consecutive trading days, then BP4 may distribute to its shareholders up to an additional 33.3% of the Lock-Up securities (or up to 100% of the Lock-Up securities on a cumulative basis).

The MOU was approved by BP4's shareholders at on January 15, 2026.

A copy of the MOU is attached hereto as Exhibit 1.1 and is incorporated herein by reference.

The foregoing description of the material terms of the MOU does not purport to be complete and is qualified in its entirety by reference to such an exhibit.