Prospectus Certification by Investment Company (Form 497J)

Mutual Fund Series Trust

Re: Mutual Fund Series Trust (the "Registrant");

File Nos. 333-132541 and 811-21872

Ladies and Gentlemen:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, the undersigned certifies (i) that the form of Prospectus that would have been filed under paragraph (c) of Rule 497 on behalf of the AlphaCentric Income Opportunities Fund, AlphaCentric Life Sciences and Healthcare Fund, AlphaCentric Premium Opportunity Fund, AlphaCentric Robotics and Automation Fund, AlphaCentric Symmetry Strategy Fund and AlphaCentric Real Income Fund, does not differ from that contained in the Registrant's Post-Effective Amendment No. 546, which was filed with the Commission on July 28, 2026 and (ii) that Post-Effective Amendment No. 546 has been filed electronically with the Commission.

Very truly yours,

_/s/ Jennifer Bailey_________

Jennifer Bailey

Secretary