Regional Situation: In epidemiological week 22, influenza activity in the Region of the Americas remains stable. In North America and the Caribbean, a downward trend is observed, with low levels of circulation. In contrast, Brazil and the Southern Cone are experiencing a sustained increase in activity, with a progressive rise in the number of detections and a positivity rate of 13.9% in EW22. Central America continues to show moderate activity, with a positivity rate of 10%, while the Andean Region continues to decline, with a positivity rate of 5.5%. At the regional level, influenza A remains the predominant virus among subtyped samples, with A(H3N2) as the dominant subtype in the Southern Hemisphere. The seasonal influenza activity index RSV shows an upward trend in most subregions, except for North America. Meanwhile, SARS-CoV-2 circulation remains stable and at low levels. Hospitalizations for acute respiratory infections (SARI) and outpatient visits for respiratory tract infections (ILI) are showing a downward trend in the Northern Hemisphere. In contrast, they remain high in the Andean Region, Brazil, and the Southern Cone, primarily associated with the circulation of influenza and RSV.