ImmunoGenesis Announces Poster Presentation at AACR 2026 Annual Meeting

Presentation details the IND-enabling work for IMGS-203, a potent Stimulator of Interferon Genes (STING) Agonist, for the treatment of Glioblastoma Multiforme (GBM)

Houston, Texas, April 15, 2026 /PR Newswire/- ImmunoGenesis, a clinical-stage biotech company developing innovative, science-driven immunotherapies, today announced that it will present a poster at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2026, which is being held from April 17-22, 2026, in San Diego, CA.

The poster presentation will include details around the IND-enabling activities for the company's potent STING Agonist, IMGS-203, for the treatment of GBM. This therapy is designed for intratumoral delivery, enabling localized immune activation with minimal systemic exposure. In orthotopic GBM models, IMGS-203 demonstrated robust anti-tumor activity and significant survival benefit. The data support a clear translational path, with pharmacologic activity confirmed across multiple species and pilot toxicology studies informing dose and delivery parameters for the GLP toxicology study and eventual clinical trial.

"IMGS-203 combines potent STING activation with a localized delivery approach designed to overcome the immunosuppressive tumor microenvironment in GBM" said Dr. Federica Pericle, Chief Scientific Officer of ImmunoGenesis. "These data support the advancement of IMGS-203 toward clinical development."

IMGS-203 Presentation Details:

GBM is a lethal malignancy with a highly immunosuppressive tumor microenvironment (TME) enriched in myeloid-derived suppressor cells, tumor-associated macrophages, and tumor-associated neutrophils. IMGS-203 is a potent STING agonist developed for intratumoral (IT) delivery, a route of administration (ROA) particularly suited for GBM, a tumor that rarely metastasizes and is readily accessible for local delivery during standard procedures such as biopsy. In vitro assays and preclinical murine studies, including a humanized model with epigenetically silenced STING, demonstrated the antitumor efficacy, specificity, and mechanism of action of IMGS-203. These studies also provided pharmacokinetic data and supported its translational potential for local delivery.

Title: IND-enabling development of a novel STING agonist, IMGS-203, for the treatment of glioblastoma

Abstract Number: 4300

Date and Time: Tuesday, April 21, 2026, 9:00 AM - 12:00 PM PT

Session: Immunomodulatory Agents

Location: Poster Section 8, Poster Board Number 4

For more information and to view the Company's abstract, visit the AACR Annual Meeting website.

About ImmunoGenesis

ImmunoGenesis is a clinical-stage biotech company dedicated to transforming immuno-oncology by targeting key mechanisms of immune resistance. The company's lead product, IMGS-001, is a cytotoxic immune checkpoint inhibitor targeting PD-L1 and PD-L2. IMGS-001 is currently in a phase 1a/b clinical trial for the treatment of immune-excluded tumors, which account for more than half of all cancers. In addition to its lead program, the company is developing a multi-mechanism strategy aimed at addressing the pathology of immune-excluded tumors by overcoming immune exclusion to enable a robust immune response in the tumor microenvironment. For more information, visit immunogenesis.com.

Contacts:

Investors:

James Barlow, President and CEO

[email protected]