Amendment to Statement of Changes in Beneficial Ownership (Form 4/A)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Oelschlager Kristen M 2. Issuer Name and Ticker or Trading Symbol CASTLE BIOSCIENCES INC [CSTL] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chief Operating Officer (Last) (First) (Middle) C/O CASTLE BIOSCIENCES, INC., 505 S FRIENDSWOOD DRIVE, SUITE 401 3. Date of Earliest Transaction (Month/Day/Year) 08/27/2025 (Street) FRIENDSWOOD, TX 77546 4. If Amendment, Date Original Filed (Month/Day/Year) 08/29/2025 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 08/27/2025 S 18,007 D $21.69(1) 100,937(2) I The Fritz Shorter Trust(3) Common Stock 52,924(2) D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Oelschlager Kristen M C/O CASTLE BIOSCIENCES, INC. 505 S FRIENDSWOOD DRIVE, SUITE 401 FRIENDSWOOD, TX 77546			Chief Operating Officer

Signatures

/s/ Frank Stokes, Attorney-in-fact		11/04/2025
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	This transaction was executed in multiple trades at prices ranging from $21.24 to $21.94, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(2)	On August 29, 2025, the Reporting Person filed a Form 4 which inadvertently reported that shares were sold by the Reporting Person directly. In fact, as reported in this amendment, the shares were sold by the Fritz Shorter Trust (the "Trust"). The original Form 4 also mistakenly indicated the wrong number of shares held by the Reporting Person directly and indirectly through the Trust. In fact, following this sale, the Reporting Person held 52,924 shares of common stock directly and 100,937 shares of common stock indirectly through the Trust. In addition, following a reconciliation of the reporting person's holdings, it was determined that the balance previously reported was understated by 68 shares, and the holdings reported herein have been adjusted accordingly.
(3)	On March 19, 2025 and on August 22, 2025, the Reporting Person transferred 96,322 and 22,622 shares to the Trust. The transfer was not a change in beneficial ownership because the Reporting Person and her spouse are the trustees and sole beneficiaries of the Trust, the Trust is revocable and the Reporting Person has voting and investment power over the shares held by the Trust.

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