Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * GOLDSMITH MARK A 2. Issuer Name and Ticker or Trading Symbol Revolution Medicines, Inc. [RVMD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) See Remarks (Last) (First) (Middle) C/O REVOLUTION MEDICINES, INC., 700 SAGINAW DRIVE 3. Date of Earliest Transaction (Month/Day/Year) 03/01/2026 (Street) REDWOOD CITY, CA 94063 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 03/01/2026 A 57,100 A $ 0 289,569(1)(2) D Common Stock 03/02/2026 M(3) 30,000 A $4.09 319,569(1) D Common Stock 03/02/2026 S(3) 700 D $98.1708(4) 318,869(1) D Common Stock 03/02/2026 S(3) 3,500 D $99.7572(5) 315,369(1) D Common Stock 03/02/2026 S(3) 3,620 D $100.7346(6) 311,749(1) D Common Stock 03/02/2026 S(3) 21,329 D $101.6023(7) 290,420(1) D Common Stock 03/02/2026 S(3) 851 D $102.1994(8) 289,569(1) D Common Stock 594,060(2) I Trust(9) Common Stock 03/02/2026 S 100 D $98.31 67,324 I Trust(10) Common Stock 03/02/2026 S 400 D $100.1225(11) 66,924 I Trust(10) Common Stock 03/02/2026 S 1,700 D $101.4743(12) 65,224 I Trust(10) Common Stock 03/02/2026 S 800 D $101.9983(13) 64,424 I Trust(10) Common Stock 03/02/2026 S 100 D $98.29 67,324 I Trust(14) Common Stock 03/02/2026 S 600 D $100.1933(15) 66,724 I Trust(14) Common Stock 03/02/2026 S 2,100 D $101.6341(16) 64,624 I Trust(14) Common Stock 03/02/2026 S 200 D $102.08 64,424 I Trust(14)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (Right to Buy)

$102.02

03/01/2026

A

128,600

(17)

02/28/2036

Common Stock

128,600

$ 0

128,600

D

Stock Option (Right to Buy)

$4.09

03/02/2026

M(1)

30,000

03/13/2023

03/12/2029

Common Stock

30,000

$ 0

47,708

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
GOLDSMITH MARK A C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY, CA 94063	X		See Remarks

Signatures

/s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith		03/03/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Includes 225,863 restricted stock units.
(2)	Reflects the transfer of 24,010 shares to the Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust.
(3)	Transaction made pursuant to a 10b5-1 trading plan adopted by Mark A. Goldsmith on December 19, 2024.
(4)	This transaction was executed in multiple trades at prices ranging from $97.83 to $98.38. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(5)	This transaction was executed in multiple trades at prices ranging from $99.12 to $100.07. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(6)	This transaction was executed in multiple trades at prices ranging from $100.14 to $101.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(7)	This transaction was executed in multiple trades at prices ranging from $101.14 to $102.11. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(8)	This transaction was executed in multiple trades at prices ranging from $102.14 to $102.32. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(9)	Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust.
(10)	Held by Jonathan Goldsmith Revocable Trust.
(11)	This transaction was executed in multiple trades at prices ranging from $99.79 to $100.71. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(12)	This transaction was executed in multiple trades at prices ranging from $100.81 to $101.79. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(13)	This transaction was executed in multiple trades at prices ranging from $101.82 to $102.14. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(14)	Held by Rebecca Goldsmith Revocable Trust.
(15)	This transaction was executed in multiple trades at prices ranging from $99.80 to $100.71. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(16)	This transaction was executed in multiple trades at prices ranging from $101.07 to $102.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
(17)	One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2026 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.
Remarks: President and Chief Executive Officer

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