Initial Statement of Beneficial Ownership (Form 3)

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Column Group IV GP, LP 2. Date of Event Requiring Statement (Month/Day/Year) 02/04/2026 3. Issuer Name and Ticker or Trading Symbol Eikon Therapeutics, Inc. [EIKN] (Last) (First) (Middle) 1 LETTERMAN DRIVE, BUILDING D, SUITE DM-900 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) 5. If Amendment, Date Original Filed (Month/Day/Year) (Street) SAN FRANCISCO, CA 94129 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 63,691 I See footnote(1) Common Stock 3,352 I See footnote(2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Preferred Stock	(3)	(3)	Common Stock	1,296,629	(3)	I	See footnote(1)
Series A Preferred Stock	(3)	(3)	Common Stock	44,249	(3)	I	See footnote(2)
Series A-1 Preferred Stock	(4)	(4)	Common Stock	1,403,568	(4)	I	See footnote(1)
Series A-1 Preferred Stock	(4)	(4)	Common Stock	47,898	(4)	I	See footnote(2)
Series C-1 Preferred Stock	(5)	(5)	Common Stock	110,928	(5)	I	See footnote(1)
Series C-1 Preferred Stock	(5)	(5)	Common Stock	3,785	(5)	I	See footnote(2)
Series D Preferred Stock	(6)	(6)	Common Stock	688,283	(6)	I	See footnote(7)
Warrant	02/14/2025	02/14/2030	Common Stock	573,569	$43.59	I	See footnote(7)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Column Group IV GP, LP 1 LETTERMAN DRIVE BUILDING D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
Column Group IV-A, LP 1 LETTERMAN DRIVE BUILDING D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
Column Group Opportunity III, LP 1 LETTERMAN DRIVE BUILDING D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
Column Group Opportunity III GP, LP 1 LETTERMAN DRIVE BUILDING D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
TCG Opportunity III GP, LLC 1 LETTERMAN DRIVE BUILDING D, SUITE DM-900 SAN FRANCISCO, CA 94129		X

Signatures

The Column Group IV, LP, by The Column Group IV GP, LP, its general partner, /s/ James Evangelista Attorney-in-Fact		02/04/2026
**Signature of Reporting Person		Date
The Column Group IV-A, LP, by The Column Group IV GP, LP, its general partner, /s/ James Evangelista Attorney-in-Fact		02/04/2026
**Signature of Reporting Person		Date
The Column Group IV GP, LP, /s/ James Evangelista Attorney-in-Fact		02/04/2026
**Signature of Reporting Person		Date
The Column Group Opportunity III, LP, by The Column Group Opportunity GP, LP its general partner, by TCG Opportunity III GP, LLC, its general partner, /s/ James Evangelista Attorney-in-Fact		02/04/2026
**Signature of Reporting Person		Date
The Column Group Opportunity GP, LP, by TCG Opportunity III GP, LLC, its general partner, /s/ James Evangelista Attorney-in-Fact		02/04/2026
**Signature of Reporting Person		Date
TCG Opportunity III GP, LLC, /s/ James Evangelista Attorney-in-Fact		02/04/2026
**Signature of Reporting Person		Date
/s/ James Evangelista, as attorney-in-fact for Tim Kutzkey		02/04/2026
**Signature of Reporting Person		Date
/s/ James Evangelista, as attorney-in-fact for Peter Svennilson		02/04/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The shares are directly held by The Column Group IV, LP ("TCG IV LP"). The Column Group IV GP, LP ("TCG IV GP LP") is the general partner of TCG IV LP and may be deemed to have voting and investment power with respect to shares directly held by TCG IV LP. Peter Svennilson and Tim Kutzkey are the managing partners of TCG IV GP LP and may each be deemed to share voting, investment and dispositive power with respect to securities directly held by TCG IV LP. Each of the Reporting Persons disclaims beneficial ownership of the securities noted herein, except to the extent of its or his pecuniary interest therein.
(2)	The shares are directly held by The Column Group IV-A, LP ("TCG IV-A LP"). TCG IV GP LP is the general partner of the TCG IV-A LP and may be deemed to have voting and investment power with respect to shares directly held by the Reporting Person. Peter Svennilson and Tim Kutzkey are the managing partners of TCG IV GP LP and may each be deemed to share voting, investment and dispositive power with respect to securities directly held by TCG IV-A LP. Each of the Reporting Persons disclaims beneficial ownership of the securities noted herein, except to the extent of its or his pecuniary interest therein.
(3)	The Series A Preferred Stock is convertible into Common Stock on a 1-for-7.4578 basis and has no expiration date. Immediately prior to the closing of the Issuer's initial public offering ("IPO"), all shares of Series A Preferred Stock will be converted into shares of Common Stock of the Issuer.
(4)	The Series A-1 Preferred Stock is convertible into Common Stock on a 1-for-7.4578 basis and has no expiration date. Immediately prior to the closing of the Issuer's IPO, all shares of Series A-1 Preferred Stock will be converted into shares of Common Stock of the Issuer.
(5)	The Series C-1 Preferred Stock is convertible into Common Stock on a 1-for-7.4578 basis and has no expiration date. Immediately prior to the closing of the Issuer's IPO, all shares of Series C-1 Preferred Stock will be converted into shares of Common Stock of the Issuer.
(6)	The Series D Preferred Stock is convertible into Common Stock on a 1-for-7.4578 basis and has no expiration date. Immediately prior to the closing of the Issuer's IPO, all shares of Series C-1 Preferred Stock will be converted into shares of Common Stock of the Issuer.
(7)	The securities are directly held by The Column Group Opportunity III, LP ("TCG Opportunity III LP"). The Column Group Opportunity III GP, LP ("TCG Opportunity III GP LP") is the general partner of TCG Opportunity III LP. TCG Opportunity III GP, LLC is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP. Each of TCG Opportunity III GP LP and TCG Opportunity III GP, LLC may be deemed to have voting, investment and dispositive power with respect to securities directly held by TCG Opportunity III LP. Peter Svennilson and Tim Kutzkey are the managing members of TCG Opportunity III GP, LLC and may each be deemed to share voting, investment and dispositive power with respect to securities directly held by TCG Opportunity III LP. Each of the Reporting Persons disclaims beneficial ownership of the securities noted herein, except to the extent of its or his pecuniary interest therein.

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