06/30/2025 | Press release | Distributed by Public on 06/30/2025 08:03
Principal Investigator: Joe Lo, Mechanical Engineering
Project Title: Influence of hypoxia on the antiviral functions of human intestinal epithelial cells
Sponsor: National Institutes of Health subaward (via University of Florida)
Amount: $283,010
The low oxygen environment (hypoxia) in the gastro-intestinal tract is fundamental for the preservation of the commensal microbiota and the maintenance of gut homeostasis. How hypoxia impacts the ability of intestinal epithelial cells to respond to enteric viruses is unknown and this constitutes the core question of this project. In collaboration with the University of Florida, Lo's team at UM-Dearborn will develop a radial microfluidic gradient platform for modeling gut villi hypoxia. The device will be verified using a conventional fiberoptic oxygen probe for the initial design. The results of this study will inform the development of novel therapeutics targeting cellular responses to hypoxia to treat enteric pathogens, as well as for the treatment of inflammatory bowel diseases which is accompanied by oxygen-dysregulation in the gut.
New Research Security Training Requirement for Certain Proposals
Effective May 1, 2025, certain sponsors (e.g., Department of Defense, Department of Energy) require research security training to be completed within 12 months prior to submittinga funding proposal (check the terms and conditions of the proposal for any such training requirements.) Follow this link to complete the Research Security Training course requirement (UMICH login and password required.)
Research security training is listed as one of four elements of a Research Security Program required by National Security Presidential Memorandum 33, issued on Jan. 14, 2021, to safeguard our research ecosystem. The "CHIPS and Science Act of 2022," Section 10634, codifies the requirement for research security training for federal research award personnel in public law. See more at the Department of Energy's website: https://www.energy.gov/ia/research-security-training-requirement
Research Events in July
Every month, the Office of Research features a resource and/or tool that is available for researchers. This month we are featuring iThenticate.
To help the U-M research community foster and uphold the highest ethical standards in research and creative practice, the Office of the Vice President for Research (OVPR) secured an institutional license for iThenticate. U-M Dearborn researchers can use the plagiarism detection software to help ensure that, in the process of advancing their research and creative practice, they do not inadvertently source others' work without appropriate reference or repurpose their previously published work in a way that violates publication license.
iThenticate compares submissions against a comprehensive database of web and scholarly content, including 190 million subscription sources and 81,000 journal articles. OVPR is pleased to provide free access to this tool to the Ann Arbor, Dearborn, and Flint campuses. Information about accessing iThenticate can be found on the research compliance website.
The Office of Research maintains a list of selected funding opportunities, organized by college on our website under Announcements. In addition, we encourage you to check out the Hanover Research subject area calendars with funding opportunities which we upload on a regular basis to our website.
Please refer to OVPR's Tracking Federal Changes 2025 pagefor more information and updates related to the Trump administration's changes to federal research funding.
Use the updated U-M Research Commonsto look up internal (to U-M) funding opportunities and Limited Submission opportunities open to Dearborn researchers.
Contact the UM-Dearborn Office of Research if you would like more information about submitting a proposal to any of the programs.