Post-Effective Amendment to Post-Effective Amendment by Investment Company (Form 485BXT)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-1A

(Check appropriate box or boxes.)

JANUS DETROIT STREET TRUST

(Exact Name of Registrant as Specified in Charter)

151 Detroit Street, Denver, Colorado 80206-4805

(Address of Principal Executive Offices) (Zip Code)

Registrant's Telephone Number, including Area Code: 303-333-3863

Cara Owen

151 Detroit Street

Denver, Colorado 80206-4805

(Name and Address of Agent for Service)

With Copies to:

Eric S. Purple

Stradley Ronon Stevens & Young, LLP

2000 K Street, N.W., Suite 700
Washington, D.C. 20006

Approximate Date of Proposed Public Offering: As soon as practicable after the effective date of this Registration Statement.

EXPLANATORY NOTE

Designation of New Effective Date for Previously Filed Amendment

Post-Effective Amendment No. 71 under the Securities Act of 1933, as amended (the "1933 Act"), and Amendment No. 72 under the Investment Company Act of 1940, as amended (the "1940 Act"), was filed with the Commission pursuant to paragraph (a)(2) of Rule 485 on August 26, 2025 to establish Janus Henderson Residential Mortgage Credit ETF, a new series of the Registrant (the "Amendment"), and pursuant to that paragraph would become effective on November 10, 2025.

This Post-Effective Amendment No. 74 under the 1933 Act and Amendment No. 75 under the 1940 Act is filed pursuant to Rule 485(b)(1)(iii) under the 1933 Act for the sole purpose of designating November 17, 2025 as the new date upon which the Amendment shall become effective.

This Post-Effective Amendment No. 74 incorporates by reference the information contained in Parts A, B, and C of the Post-Effective Amendment No. 71, which was filed on August 26, 2025.

The Registrant is a series fund with multiple series currently established. This Post-Effective Amendment No. 74 is not intended to update or amend the prospectuses or statements of additional information of any series except as described above.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, and the Investment Company Act of 1940, as amended, the Registrant certifies that it meets all of the requirements for effectiveness of this Amendment to its Registration Statement pursuant to Rule 485(b) under the Securities Act of 1933, as amended, and has duly caused this Post-Effective Amendment to its Registration Statement to be signed on its behalf by the undersigned, thereto duly authorized, in the City of Denver, and State of Colorado, on the 7^th day of November, 2025.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following person(s) in the capacities and on the dates indicated.