Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * CLARK IAN T 2. Issuer Name and Ticker or Trading Symbol Guardant Health, Inc. [GH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 3100 HANOVER STREET 3. Date of Earliest Transaction (Month/Day/Year) 12/05/2025 (Street) PALO ALTO, CA 94304 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/05/2025 M 9,105 A $38.42 18,956 I By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account Common Stock 12/05/2025 M 8,803 A $38.005 27,759 I By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account Common Stock 12/05/2025 M 10,703 A $31.84 38,462 I By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account Common Stock 12/05/2025 S 8,156 D $106.666(1) 30,306 I By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account Common Stock 12/05/2025 S 17,055 D $107.2703(2) 13,251 I By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account Common Stock 12/05/2025 S 3,400 D $108.0454(3) 9,851 I By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (Right to Buy)

$38.42

12/05/2025

M

9,105

(4)

06/15/2032

Common Stock

9,105

$ 0

0

D

Stock Option (Right to Buy)

$38.005

12/05/2025

M

8,803

(5)

06/14/2033

Common Stock

8,803

$ 0

0

D

Stock Option (Right to Buy)

$31.84

12/05/2025

M

10,703

(6)

06/12/2034

Common Stock

10,703

$ 0

0

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
CLARK IAN T 3100 HANOVER STREET PALO ALTO, CA 94304	X

Signatures

/s/ John G. Saia, as attorney-in-fact for Ian T. Clark		12/08/2025
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $105.88 to $106.87. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
(2)	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.88 to $107.87. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
(3)	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $107.885 to $108.480. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
(4)	The Stock Options vest in full on the one-year anniversary of the grant date, June 15, 2022 or the date of the next year annual stockholders meeting, whichever is earlier.
(5)	The stock option vests in full on the one-year anniversary of the grant date, June 14, 2023 or the date of the next year annual stockholders meeting, whichever is earlier.
(6)	The stock option vests in full on the one-year anniversary of the grant date, June 12, 2024 or the date of the next year annual stockholders meeting, whichever is earlier.

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