UC Irvine discovery leads to TIME-honored memory device

A groundbreaking discovery by UC Irvine neurobiologist Michael Leon has led to the development of Memory Air. This scent-based device enhances memory - and it has just been named one of TIME's Best Inventions of 2025 in the Health & Wellness category.

Leon's research revealed that stimulating the sense-of-smell center of the brain during sleep can dramatically improve memory consolidation.

Recognizing the potential of this innovation, UC Irvine's Beall Applied Innovation office worked with Leon to patent the technology in 2020 under the title "Cognition and Memory Enhancement via Multiple Odorant Stimulation." The patent covers methods and devices that deliver scent sequences to stimulate neural activity, particularly during sleep.

To bring the invention to market, Leon partnered with longtime colleague Alan Bernstein to form Science Lab 3, a startup focused on translating the research into a consumer-ready product. UC Irvine granted Science Lab 3 an exclusive license to the patented technology, enabling the company to attract investors and begin development.

The result is Memory Air, an over-the-counter device that delivers a curated sequence of 40 scents throughout the night. Designed to be non-invasive and easy to use, the device stimulates the brain's olfactory system to promote memory formation - especially beneficial for aging adults and those experiencing cognitive decline.

Science Lab 3 received foundational support from UC Irvine's entrepreneurial ecosystem, including guidance from Beall Applied Innovation's licensing team and access to resources such as prototyping referrals and grant programs.

Leon's journey from lab to market exemplifies UC Irvine's commitment to research translation and innovation. With centralized support and streamlined licensing, the university empowers faculty to turn discoveries into life-changing products.

The makers of Memory Air received foundational support from UC Irvine's entrepreneurial ecosystem, including guidance from Beall Applied Innovation's licensing team.