Initial Registration Statement for Employee Benefit Plan (Form S-8)

As filed with the United States Securities and Exchange Commission on May 7, 2026

Registration No. 333-

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

Under

THE SECURITIES ACT OF 1933

INSPIRE MEDICAL SYSTEMS, INC.

(Exact Name of Registrant as Specified in its Charter)

Delaware						26-1377674
(State or other jurisdiction of incorporation or organization)						(I.R.S. Employer Identification No.)

5500 Wayzata Blvd., Suite 1600

Golden Valley, MN 55416

(Address of Principal Executive Offices) (Zip Code)

INSPIRE MEDICAL SYSTEMS, INC. AMENDED AND RESTATED 2018 INCENTIVE AWARD PLAN

(Full Title of the Plan)

Timothy P. Herbert

President and Chief Executive Officer

5500 Wayzata Blvd., Suite 1600

Golden Valley, MN 55416

(Name and Address of Agent for Service)

(844) 672-4357

(Telephone Number, including Area Code, of Agent for Service)

Copies to:

B. Shayne Kennedy

Nathan Ajiashvili

Latham & Watkins LLP

650 Town Center Drive, 20th Floor

Costa Mesa, CA 92626

(714) 540-1235

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer

x

Accelerated filer

o

Non-accelerated filer

o

Smaller reporting company

o

Emerging growth company

o

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨

EXPLANATORY NOTE

This Registration Statement on Form S-8 is being filed for the purpose of registering 2,600,000 shares of the Registrant's common stock, par value $0.001 per share, to be issued pursuant to the Inspire Medical Systems, Inc. Amended and Restated 2018 Incentive Award Plan (the "A&R Plan"). On April 30, 2026, the Registrant's stockholders approved the amendment and restatement of the Inspire Medical Systems, Inc. 2018 Incentive Award Plan (the "2018 Plan") to, among other things, authorize the issuance of 9,903,857 shares of the Registrant's common stock for awards under the A&R Plan, which includes 7,303,857 shares previously authorized for issuance under the 2018 Plan plus an increase of 2,600,000 shares, and extend the term of the 2018 Plan to March 6, 2036.

INCORPORATION BY REFERENCE OF CONTENTS OF

REGISTRATION STATEMENTS ON FORM S-8

The contents of the Registration Statement on Form S-8 (File No. 333-224731), including any amendments thereto, filed with the Securities and Exchange Commission, relating to the A&R Plan (as an amendment and restatement of the 2018 Plan), are incorporated by reference herein.

Item 8. Exhibits.

The following documents are filed as exhibits to this Registration Statement:

Exhibit Number						Description of Exhibit
4.1						Seventh Amended and Restated Certificate of Incorporation of Inspire Medical Systems, Inc. (incorporated herein by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K (File No. 001-38468) filed on May 7, 2018)
4.2						Certificate of Amendment to the Seventh Amended and Restated Certificate of Incorporation of Inspire Medical Systems, Inc. (incorporated herein by reference to Exhibit 3.2 to the Company's Quarterly Report on Form 10-Q (File No. 001-38468) filed on May 4, 2026)
4.3						Amended and Restated Bylaws of Inspire Medical Systems, Inc. (incorporated herein by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K (File No. 001-38468) filed on February 11, 2026)
4.4						Form of Certificate of Common Stock (incorporated herein by reference to Exhibit 4.1 to the Company's Registration Statement on Form S-1 (File No. 333-224176) filed on April 23, 2018)
10.1						Inspire Medical Systems, Inc. Amended and Restated 2018 Incentive Award Plan (incorporated herein by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K (File No. 001-38468) filed on May 5, 2026)
5.1*						Opinion of Latham & Watkins LLP, counsel to the Registrant
23.1*						Consent of Ernst & Young LLP, independent registered public accounting firm for Inspire Medical Systems, Inc.
23.3*						Consent of Latham & Watkins LLP (contained in Exhibit 5.1)
24.1*						Powers of Attorney (included on the signature page of the Registration Statement)
107*						Filing Fee Table

* Filed herewith.

SIGNATURES

Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Golden Valley, State of Minnesota, on this 7th day of May, 2026.

			INSPIRE MEDICAL SYSTEMS, INC.
By:			/s/ Timothy P. Herbert
			Timothy P. Herbert
			Chief Executive Officer and President

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Timothy P. Herbert and Matthew J. Osberg, and each of them, as his or her true and lawful attorney-in-fact and agent with full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments or any abbreviated registration statement and any amendments thereto filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, increasing the number of securities for which registration is sought), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact, proxy, and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact, proxy and agent, or his substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

Signature

Title

Date

/s/ Timothy P. Herbert

Chief Executive Officer (principal executive officer), President and Chair of the Board of Directors

May 7, 2026

Timothy P. Herbert

/s/ Matthew J. Osberg

Chief Financial Officer (principal financial and accounting officer)

May 7, 2026

Matthew J. Osberg

/s/ Shelley G. Broader

May 7, 2026

Shelley G. Broader

Director

/s/ Cynthia B. Burks

May 7, 2026

Cynthia B. Burks

Director

/s/ Myriam J. Curet, M.D.

May 7, 2026

Myriam J. Curet, M.D.

Director

/s/ Gary L. Ellis

May 7, 2026

Gary L. Ellis

Director

/s/ Georgia Melenikiotou

May 7, 2026

Georgia Melenikiotou

Director

/s/ Dana G. Mead, Jr.

May 7, 2026

Dana G. Mead, Jr.

Director

/s/ Shawn T McCormick

May 7, 2026

Shawn T McCormick

Director

/s/ Casey Tansey

May 7, 2026

Casey Tansey

Director