Additional Proxy Soliciting Materials (Form DEFA14A)

Your Vote Counts! Smartphone users Point your camera here and vote without entering a control number For complete information and to vote, visit www.ProxyVote.com Control # V96780-P47550 *Please check the meeting materials for any special requirements for meeting attendance. OCULAR THERAPEUTIX, INC. 14 CROSBY DRIVE, 3RD FLOOR BEDFORD, MA 01730 OCULAR THERAPEUTIX, INC. Important Notice Regarding the Availability of Proxy Materials for the Stockholders Meeting to Be Held on June 10, 2026 2026 Annual Meeting June 10, 2026 8:30 AM ET Virtual Meeting Site: www.virtualshareholdermeeting.com/OCUL2026 You invested in OCULAR THERAPEUTIX, INC. and it's time to vote! You have the right to vote on proposals being presented at the Annual Meeting. Get informed before you vote View the Notice and Proxy Statement and the 2025 Annual Report online by visiting www.ProxyVote.com OR you can receive a free paper or email copy of the materials by requesting prior to May 27, 2026 to ensure timely delivery. If you would like to request a copy of the materials for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to [email protected]. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Vote in Advance of the Meeting Vote by June 9, 2026 11:59 PM ET. Visit www.ProxyVote.com Vote Virtually at the Meeting* June 10, 2026 8:30 AM ET Visit www.virtualshareholdermeeting.com/OCUL2026

Vote at www.ProxyVote.com Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click "Delivery Settings". Voting Items Board Recommends V96781-P47550 THIS IS NOT A VOTABLE BALLOT This is an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. Please follow the instructions on the reverse side to vote these important matters. 1. To elect two Class III directors, each to serve until the 2029 Annual Meeting of Stockholders and until his or her successor is duly elected and qualified. Nominees: For 01) Pravin U. Dugel, M.D. 02) Merilee Raines 2. To approve an advisory vote on named executive officer compensation. For 3. To approve, on a non-binding, advisory basis, the frequency of future advisory votes to approve named executive officer compensation. 1 Year 4. To approve an amendment to the Ocular Therapeutix, Inc. 2021 Stock Incentive Plan, as amended, to increase the number of shares of common stock issuable thereunder by 10,000,000 shares. For 5. To ratify the appointment of PricewaterhouseCoopers LLP as Ocular Therapeutix's independent registered public accounting firm for the fiscal year ending December 31, 2026. For NOTE: The shares represented by this proxy will be voted by the proxy holders, in their discretion, upon such other business as may properly come before the meeting or any adjournment or postponement thereof.