Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * COLUMN GROUP III GP, LP 2. Issuer Name and Ticker or Trading Symbol Surrozen, Inc./DE [SRZN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1 LETTERMAN DR., BLDG D, SUITE DM-900 3. Date of Earliest Transaction (Month/Day/Year) 10/20/2026 (Street) SAN FRANCISCO, CA 94129 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/20/2026 X(1) 485,830 A $11.60(2) 1,386,122 I By The Column Group III, LP(3) Common Stock 10/20/2026 X(1) 548,653 A $11.60(2) 1,565,311 I By The Column Group III-A, LP(4) Common Stock 10/20/2026 X(1) 517,241 A $11.60(2) 862,068 I By The Column Group Opportunity III, LP(5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Second Tranche Units (Right to Buy)	$11.60(2)	10/20/2026		X(1)			728,745(6)	(1)	(1)	Common Stock	728,745(6)	(1)	0	I	By The Column Group III, LP(3)
Second Tranche Units (Right to Buy)	$11.60(2)	10/20/2026		X(1)			822,980(7)	(1)	(1)	Common Stock	822,980(7)	(1)	0	I	By The Column Group III-A, LP(4)
Second Tranche Units (Right to Buy)	$11.60(2)	10/20/2026		X(1)			775,861(8)	(1)	(1)	Common Stock	775,861(8)	(1)	0	I	By The Column Group Opportunity III, LP(5)
Series E Common Warrants	$11.54	10/20/2026		X(1)		242,915		(9)	(9)	Common Stock	242,915	(9)	404,858	I	By The Column Group III, LP(3)
Series E Common Warrants	$11.54	10/20/2026		X(1)		274,327		(9)	(9)	Common Stock	274,327	(9)	457,211	I	By The Column Group III-A, LP(4)
Series E Common Warrants	$11.54	10/20/2026		X(1)		258,620		(9)	(9)	Common Stock	258,620	(9)	431,034	I	By The Column Group Opportunity III, LP(5)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
COLUMN GROUP III GP, LP 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
COLUMN GROUP III-A, LP 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
COLUMN GROUP III, LP 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
Column Group Opportunity III, LP 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
Column Group Opportunity III GP, LP 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
TCG Opportunity III GP, LLC 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X
Svennilson Peter 1 LETTERMAN DR., BLDG D, SUITE DM-900 SAN FRANCISCO, CA 94129		X

Signatures

/s/ The Column Group III GP, LP by /s/ James Evangelista, Attorney-in-Fact		10/22/2026
**Signature of Reporting Person		Date
/s/ The Column Group III-A, LP by The Column Group III GP, LP, its general partner /s/ James Evangelista, Attorney-in-Fact		10/22/2026
**Signature of Reporting Person		Date
/s/ The Column Group III, LP by The Column Group III GP, LP, its general partner /s/ James Evangelista, Attorney-in-Fact		10/22/2026
**Signature of Reporting Person		Date
/s/ The Column Group Opportunity III, LP by /s/ James Evangelista, Attorney-in-Fact		10/22/2026
**Signature of Reporting Person		Date
/s/ The Column Group Opportunity III GP, LP by /s/ James Evangelista, Attorney-in-Fact		10/22/2026
**Signature of Reporting Person		Date
/s/ TCG Opportunity III GP, LLC by /s/ James Evangelista, Attorney-in-Fact		10/22/2026
**Signature of Reporting Person		Date
/s/ James Evangelista, as attorney-in-fact for Peter Svennilson		10/22/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each Second Tranche Unit consists of (a) one share of the Issuer's Common Stock and (b) one half of a Series E Common Warrant to purchase shares of Common Stock. The Second Tranche Units were purchased in the Issuer's private placement on October 20, 2026 (the "2026 Private Placement").
(2)	Represents a price per unit, consisting of (i) $11.5375 per share of the Issuer's Common Stock and (ii) $0.0625 attributable to accompanying warrants to purchase shares of the Issuer's Common Stock, which The Column Group III, LP ("TCG III LP"), The Column Group III-A, LP ("TCG III-A LP") and The Column Group Opportunity III, LP ("TCG Opportunity III LP") purchased in the Issuer's 2026 Private Placement.
(3)	The securities are directly held by The Column Group III, LP ("TCG III LP"). The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are Peter Svennilson and Tim Kutzkey, a member of the Issuer's board of directors (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such securities. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.
(4)	The securities are directly held by The Column Group III-A, LP ("TCG III-A LP"). TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such securities. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.
(5)	The securities are directly held by The Column Group Opportunity III, LP ("TCG Opportunity III LP"). The Column Group Opportunity III GP, LP ("TCG Opportunity III GP LP") is the general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. TCG Opportunity III GP, LLC ("TCG Opportunity III GP LLC") is the general partner of TCG Opportunity III GP LP and the ultimate general partner of TCG Opportunity III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing members of TCG Opportunity III GP LLC are the Managing Partners. TCG Opportunity III GP LP, TCG Opportunity III GP LLC and each of the Managing Partners disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.
(6)	Consists of (a) 485,830 shares of the Issuer's Common Stock and (b) 242,915 Series E Common Warrants to purchase shares of the Issuer's Common Stock.
(7)	Consists of (a) 548,653 shares of the Issuer's Common Stock and (b) 274,327 Series E Common Warrants to purchase shares of the Issuer's Common Stock.
(8)	Consists of (a) 517,241 shares of the Issuer's Common Stock and (b) 258,620 Series E Common Warrants to purchase shares of the Issuer's Common Stock.
(9)	These Series E Common Warrants are exercisable immediately and will not expire until exercised in full (subject to certain beneficial ownership limitations).

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