Top 5 hospitals in 10 major US cities

If you're selling to hospitals, you already know how important it is to do your research on prospects and market changes.

You need to stay on top of a perpetually consolidating and shifting healthcare landscape. With thousands of hospitals and facilities in play, you also need to be able to triage and prioritize your most strategic accounts.

But there is only so much time in the day. How can you make sure you are really targeting the correct hospitals and key stakeholders?

To help you better navigate the healthcare market, here are the top five hospitals, ranked by net patient revenue, for some of the U.S.' major cities:

Fig. 1 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in New York City?

New York-Presbyterian Hospital/Weill Cornell Medical Center has the highest net patient revenue in New York City, followed by Tisch Hospital. With about $10.1 billion in NPR, it's also the highest-earning hospital in the country.

Both New York-Presbyterian Hospital/Weill Cornell Medical Center and Tisch Hospital are affiliated with prominent colleges. Cornell University and Columbia University are affiliated with New York-Presbyterian Hospital/Weill Cornell Medical Center while Tisch Hospital is affiliated with NYU School of Medicine.

Many college or university-affiliated hospitals and academic medical centers are actively engaged in cutting-edge research that often includes greater access to innovative procedures and quality care, especially since many college hospitals also serve as teaching and academic hospitals.

Memorial Sloan Kettering Cancer takes the third slot. As one of the top cancer centers in the country, patients from across the state and country seek out care there.

Rounding out the top five are two hospitals from the Mount Sinai Health System-one of the prominent integrated delivery networks (IDNs) in the area. Want more even more insights? Discover the top 25 hospitals in New York.

Explore more New York City hospital lists.

Fig. 2 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Los Angeles?

Ronald Reagan UCLA Medical Center tops the list for the hospital with the highest net patient revenue in Los Angeles, with an NPR of about $2.9 billion.

Many of the LA hospitals on the list are academic medical centers or teaching hospitals.

Explore more Los Angeles hospitals.

Fig. 3 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Chicago?

Northwestern Memorial Hospital and UChicago Medicine Mitchell Hospital top the list, both with an approximate NPR of $2.6 billion. These two facilities, as well as Rush University Medical Center, are designated teaching hospitals and academic medical centers.

Additionally, the Ann & Robert H. Lurie Children's Hospital of Chicago makes the list, as it is one of the largest and top-ranked pediatric providers in the region. Want a more comprehensive look? Discover the top hospitals in Illinois.

Explore more Chicago hospitals.

Fig. 4 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in DC?

Two MedStar Health hospitals round out the top three hospitals in the Washington, D.C. area, with MedStar Washington Hospital Center reporting an NPR of $1.6 billion. MedStar Health serves the Washington, D.C. and Baltimore metropolitan area with 10 hospitals, 40 urgent care centers, 31 imaging centers, and 13 ambulatory surgery centers.

Children's National Hospital takes the second spot on the list and is one of the country's top-ranked pediatric medical centers.

Discover more Washington D.C. hospital lists.

Fig. 5 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in San Francisco?

UCSF Helen Diller Medical Center has the most reported net patient revenue on our list of San Francisco hospitals, with an NPR of approximately $6.1 billion, outpacing the other four entries on the list.

Uncover more data on hospitals in California.

Fig. 6 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Boston?

Massachusetts General Hospital Takes the first spot on our list with more than $4.1 billion in NPR. The facility is part of the Mass General Brigham system, one of the top health systems in the Boston area.

Two specialized institutions, the Dana-Faber Cancer Institute and Boston's Children's Hospital make an appearance on our list, with a reported NPR of $2.6 billion and $2.0 billion respectively. Looking to take a deeper dive into MA hospitals? Discover the top 20 hospitals in Massachusetts.

Explore more Boston hospital data.

Fig. 7 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Philadelphia?

The Hospital of the University of Pennsylvania tops the list with nearly $3.7 billion in net patient revenue. Not far behind it is Children's Hospital of Philadelphia with about $3.1 billion in net patient revenue. Looking for more insights? Discover our list of Pennsylvania's largest hospitals.

Discover more Philadelphia hospital data.

Fig. 8 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Miami?

Sylvester Comprehensive Cancer Center generates the highest amount of net patient revenue in Miami, followed by Baptist Hospital and Jackson Memorial Hospital-the latter of which is one of the largest U.S. hospitals by number of staffed beds.

It's not surprising a cancer center takes the top spot as they are often quite profitable, and this particular hospital hosts a large number of clinical trials and is a hub for cancer research as well. See where Miami's hospitals fall on our list of the largest hospitals in Florida.

Explore additional Miami hospitals.

Fig. 9 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Denver?

Denver Health Main Campus comes out far ahead of the other hospitals on the list in the city as its net patient revenue is nearly half a billion more than Presbyterian/St. Luke's Medical Center in second place.

The majority of healthcare facilities in Denver Health's system are Federally Qualified Health Centers. Denver Health serves a third of the city's residents, which likely accounts for its top spot.

Learn how Denver's hospitals rank on our list of top hospitals in Colorado.

Fig. 10 Data from the Definitive Healthcare HospitalView product. Financial and clinical data is from the latest Medicare Cost Report release. Data accessed September 2025.

What hospitals have the highest net patient revenue in Dallas?

The William P. Clements Jr. University Hospital is the top hospital in Dallas, with more than $2.6 billion in net patient revenue. It's also an academic medical center and teaching hospital affiliated with UT Southwestern Medical School.

Behind that, comes Children's Medical Center Dallas, another top-ranked pediatric hospital. Children's Medical Center Dallas is also designated as a Level I Pediatric Trauma Center.

Medical City Dallas, the fourth-place entry in our list, is one of the highest-earning Health Corporation of America hospitals. For more data, discover the largest hospitals in Texas.

Discover how these hospitals compare to other top hospitals in the Dallas-Fort Worth area.

Which type of hospital generates the most revenue in cities?

Based on these rankings, it's clear that there are a few types of hospitals that generate the highest amount of net patient revenue:

• Children's hospitals: The billions of dollars flowing through children's hospitals every year pay for the care of thousands of children, many of them extremely sick or suffering from chronic conditions requiring a lifetime of treatment. Hospital officials say costs are high because the care is complicated, and the technology is expensive. In addition, the hospitals help fund research into the causes and treatment of diseases.
• Teaching hospitals: Affiliated with medical schools and associated with high costs, teaching hospitals are the training grounds for the next generation of physicians. The reason for the expense? Not only does Medicare pay teaching hospitals more, to compensate them for their educational mission, but also these hospitals command higher prices in the commercial market due to the medical-school affiliation.
• Cancer centers: Cancer treatments can be costly due to expensive drugs, cutting-edge treatments, the necessity for experienced doctors with high salaries, and lengthy hospital stays.

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