Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Hippel James 2. Issuer Name and Ticker or Trading Symbol BIO-TECHNE Corp [TECH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) CFO (Last) (First) (Middle) 614 MCKINLEY PLACE NE 3. Date of Earliest Transaction (Month/Day/Year) 11/03/2025 (Street) MINNEAPOLIS, MN 55413 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/03/2025 M 13,159 A $ 0 143,042 D Common Stock 11/03/2025 M 11,545 A $ 0 154,587 D Common Stock 11/03/2025 F 11,865 D $62.57 142,722 D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Options (Right to Buy)	$47.6							(1)	08/07/2026	Common Stock	186,068		186,068	D
Stock Options (Right to Buy)	$66.97							(1)	08/05/2027	Common Stock	167,328		167,328	D
Stock Options (Right to Buy)	$120.46							(1)	08/06/2028	Common Stock	40,536		40,536	D
Stock Options (Right to Buy)	$94.52							(3)	08/15/2029	Common Stock	45,220		45,220	D
Performance Restricted Stock Units	(2)							(4)	(4)	Common Stock	13,865		13,865	D
Performance Stock Options (Right to Buy)	$84.61							(4)	08/15/2030	Common Stock	37,314		37,314	D
Stock Options (Right to Buy)	$84.61							(5)	08/15/2030	Common Stock	45,923		45,923	D
Restricted Stock Units	(2)	11/03/2025		M			13,159	(6)	(6)	Common Stock	13,159	$ 0	0	D
Performance Restricted Stock Units	(2)							(7)	(7)	Common Stock	24,062		24,062	D
Restricted Stock Units	(2)							(8)	(8)	Common Stock	4,010		8,021	D
Stock Options (Right to Buy)	$74.91							(9)	08/15/2034	Common Stock	32,417		32,417	D
Restricted Stock Units	(2)	11/03/2025		M			11,545	(10)	(10)	Common Stock	11,545	$ 0	23,089	D
Performance Restricted Stock Units	(2)							(11)	(11)	Common Stock	29,420		29,420	D
Restricted Stock Units	(2)							(12)	(12)	Common Stock	14,710		14,710	D
Stock Options (Right to Buy)	$53.6							(13)	08/15/2035	Common Stock	37,632		37,632	D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Hippel James 614 MCKINLEY PLACE NE MINNEAPOLIS, MN 55413			CFO

Signatures

/s/ Andrew Nick as Attorney-in-Fact for James Hippel pursuant to Power of Attorney previously filed		11/05/2025
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Fully exercisable.
(2)	Each restricted stock unit represents a contingent right to receive one share of Bio-Techne Corporation common stock.
(3)	Options to purchase 11,305 shares vest on each of 8/15/2023, 8/15/2024, 8/15/2025 and 8/15/2026.
(4)	Vests in full or in part on 8/15/2026 if certain performance goals are achieved (or such later date as performance is certified by the Administrator).
(5)	Options to purchase 11,481 shares vest on each of 8/15/2024, 8/15/2025 and 8/15/2027, and options to purchase 11,480 shares vest on 8/15/2026.
(6)	13,159 restricted stock units vest on 11/1/2025.
(7)	Vests in full or in part on 8/15/2027 if certain performance goals are achieved (or such later date as performance is certified by the Administrator).
(8)	4,010 restricted stock units vest on each of 8/15/2025 and 8/15/2026, and 4,011 restricted stock units vest on 8/15/2027.
(9)	Options to purchase 8,104 shares vest on each of 8/15/2025, 8/15/2026 and 8/15/2027, and options to purchase 8,105 shares vest on 8/15/2028.
(10)	11,545 restricted stock units vest on each of 11/1/2025 and 11/1/2026; and 11,544 restricted stock units vest on 11/1/2027.
(11)	Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator).
(12)	4,903 restricted stock units vest on each of 8/15/2026 and 8/15/2027, and 4,904 restricted stock units vest on 8/15/2028.
(13)	Options to purchase 12,544 shares vest on each of 8/15/2026, 8/15/2027 and 8/15/2028.

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