November 2025: What's New from the Fertility and Sterility Family of Journals

November 2025: What's New from the Fertility and Sterility Family of Journals

Here's a peek at this month's issues from our family of journals! As an ASRM Member, you can access all of our journals.

From Fertility and Sterility

Human Embryo Testing: Phased Validation: from Innovation to Practice.

The field of embryo diagnostics has undergone a remarkable transformation over the past few decades, evolving from rudimentary assessments of morphology to sophisticated genomic, morphokinetic, and molecular analyses. Preimplantation testing of human embryos-once a specialized adjunct to in vitro fertilization-is now a rapidly expanding domain with profound implications for reproductive decision-making, clinical outcomes, and ethical discourse. Yet, with these advances comes a challenge: how do we ensure that innovation translates into meaningful, evidence-based improvement in patient care? This special issue of Fertility and Sterility brings together leading investigators, clinicians, laboratory scientists, statisticians, ethicists, and patient voices to provide a comprehensive examination of embryo diagnostics from conceptual foundation to clinical application and postimplementation oversight.

A randomized controlled trial of counseling and educational methods on preimplantation genetic testing for aneuploidy for patients pursuing in vitro fertilization

This randomized controlled trial prospectively compares methods of education and counseling on preimplantation genetic testing for aneuploidy. Patients were randomized in a 1:1:1 ratio to one of three groups: reproductive endocrinology and infertility (REI) provider counseling only (reference group), REI provider counseling and a handout, or REI provider counseling, a handout, and a brief genetic counseling intervention. Patient and partner knowledge improved with educational handouts and brief genetic counseling interventions

From F&S Reports

Outcomes of assisted reproductive technology after radical abdominal trachelectomy for early-stage cervical cancer

This paper investigates clinical characteristics and in vitro fertilization (IVF) outcomes in patients after radical abdominal trachelectomy (RAT) for early-stage cervical cancer. The live birth rate in the RAT group was comparable to that in the age-matched control group, indicating that RAT does not negatively impact assisted reproductive technologies outcomes. Age at first oocyte retrieval, number of oocytes retrieved, presence of cervical stenosis, and endometrial thickness at ET may influence IVF outcomes after RAT.

From F&S Science

Euploid but failing to implant? Insights from trophectoderm transcriptomics of euploid blastocysts using an in vitro model

This study investigates transcriptomic differences in mural trophectoderm (TE) cells of euploid human blastocysts on the basis of their ability to remain attached in extended in vitro culture and to identify gene expression profiles associated with competence for implantation. The study demonstrates that mural TE gene expression differs significantly between euploid blastocysts that attach and those that do not, highlighting molecular pathways potentially linked to implantation success. Despite human implantation typically occurring through the polar TE, mural TE transcriptomic profiles may provide predictive value for embryo selection and deepen our understanding of early implantation biology.

From F&S Reviews

Immunocompetent mouse models of endometriosis: a systematic review and meta-analysis

This review synthesizes and compares the measurable parameters that researchers have used in various immunocompetent mouse models of endometriosis. The degree of heterogeneity, risk of bias, and low quality of evidence emphasize the need for a call to action. Model standardization, agreed on by the clinical and translational research community, would improve reproducibility and allow for evidenced-based translational outcomes, especially in the setting of preclinical endometriosis studies.

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