J. Craig Venter Institute Inc.
08/24/2026 | Press release | Archived content
Genetic liability to addiction underlies comorbid bipolar and substance use disorders
Biological psychiatry. 2026-08-24;
Genetic liability to addiction underlies comorbid bipolar and substance use disorders
Ystaas LAR, Parekh P, Parker N, Akkouh I, Birkenæs V, Sønderby IE, Koch E, Hagen E, Frei O, Shadrin A, Andreassen OA, O'Connell KS
PMID: 42636965
Abstract
Bipolar disorder (BIP) frequently co-occurs with heightened substance use (SU) and substance use disorders (SUDs). Although the strong co-occurrence of these heritable traits points to shared genetic susceptibility, the extent to which there are differences in how SU and SUD overlap with BIP genetic architecture remains unclear.
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