Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * Venrock Healthcare Capital Partners III, L.P. 2. Issuer Name and Ticker or Trading Symbol Lycia Therapeutics, Inc. [LYCA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O VENROCK, 7 BRYANT PARK, 23RD FLOOR 3. Date of Earliest Transaction (Month/Day/Year) 10/28/2026 (Street) NEW YORK, NY 10018 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 10/28/2026 P 10,570(1) A $25.23(2) 6,835,803(3) I By Funds(4)(5)(6) Common Stock 10/28/2026 P 4,430(7) A $25.97(8) 6,840,233(9) I By Funds(4)(5)(6) Common Stock 10/29/2026 P 1,000(10) A $26.33(11) 6,841,233(12) I By Funds(4)(5)(6) Common Stock 10/30/2026 P 8,804(13) A $26.27(14) 6,850,037(15) I By Funds(4)(5)(6) Common Stock 10/30/2026 P 200(16) A $26.86(17) 6,850,237(18) I By Funds(4)(5)(6)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Venrock Healthcare Capital Partners III, L.P. C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
VHCP Co-Investment Holdings III, LLC C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
VHCP Management III, LLC C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
Venrock Healthcare Capital Partners EG, L.P. C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
VHCP Management EG, LLC C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
Venrock Healthcare Capital Partners XP, L.P. C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
VHCP Management XP, LLC C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
Koh Bong Y C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X
Shah Nimish P C/O VENROCK 7 BRYANT PARK, 23RD FLOOR NEW YORK, NY 10018		X

Signatures

Venrock Healthcare Capital Partners III, L.P., By: VHCP Management III, LLC, Its: General Partner, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
VHCP Co-Investment Holdings III, LLC, By: VHCP Management III, LLC, Its: Manager, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
VHCP Management III, LLC, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
Venrock Healthcare Capital Partners EG, L.P., By: VHCP Management EG, LLC, Its: General Partner, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
VHCP Management EG, LLC, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
Venrock Healthcare Capital Partners XP, L.P., By: VHCP Management XP, LLC, Its: General Partner, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
VHCP Management XP, LLC, By: /s/ Sherman G. Souther, Authorized Signatory		10/30/2026
**Signature of Reporting Person		Date
Bong Y. Koh, By: /s/ Sherman G. Souther, Attorney-in-Fact		10/30/2026
**Signature of Reporting Person		Date
Nimish P. Shah, By: /s/ Sherman G. Souther, Attorney-in-Fact		10/30/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Consists of (i) 4,804 shares held by Venrock Healthcare Capital Partners III, L.P. ("VHCP3"); (ii) 481 shares held by VHCP Co-Investment Holdings III,LLC ("VHCP Co-3"); and (iii) 5,285 shares held by Venrock Healthcare Capital Partners EG, L.P. ("VHCP EG").
(2)	The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $24.77 to $25.50 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.
(3)	Consists of (i) 1,762,936 shares held by VHCP3; (ii) 176,435 shares held by VHCP Co-3; (iii) 4,244,642 shares held by VHCP EG; and (iv) 651,790 shares held by Venrock Healthcare Capital Partners XP, L.P. ("VHCP XP").
(4)	VHCP Management III, LLC ("VHCPM3") is the general partner of VHCP3 and the manager of VHCP Co-3 and may be deemed to beneficially own the shares held by VHCP3 and VHCP Co-3. Bong Koh and Nimish Shah are the voting members of VHCPM3 and may be deemed to beneficially own these shares. Each of VHCPM3 and Messrs. Koh and Shah expressly disclaims beneficial ownership over these shares except to the extent of its or his indirect pecuniary interest therein.
(5)	VHCP Management EG, LLC ("VHCPMEG") is the general partner of VHCP EG and may be deemed to beneficially own the shares held by VHCP EG. Bong Koh and Nimish Shah are the voting members of VHCPMEG and may be deemed to beneficially own these shares. Each of VHCPMEG and Messrs. Koh and Shah expressly disclaims beneficial ownership over these shares except to the extent of its or his indirect pecuniary interest therein.
(6)	VHCP Management XP, LLC ("VHCPMXP") is the general partner of VHCP XP and may be deemed to beneficially own the shares held by VHCP XP. Bong Koh and Nimish Shah are the voting members of VHCPMXP and may be deemed to beneficially own these shares. Each of VHCPMXP and Messrs. Koh and Shah expressly disclaims beneficial ownership over these shares except to the extent of its or his indirect pecuniary interest therein.
(7)	Consists of (i) 2,013 shares held by VHCP3; (ii) 202 shares held by VHCP Co-3; and (iii) 2,215 shares held by VHCP EG.
(8)	The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $25.88 to $26.00 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.
(9)	Consists of (i) 1,764,949 shares held by VHCP3; (ii) 176,637 shares held by VHCP Co-3; (iii) 4,246,857 shares held by VHCP EG; and (iv) 651,790 shares held by VHCP XP.
(10)	Consists of (i) 455 shares held by VHCP3; (ii) 45 shares held by VHCP Co-3; and (iii) 500 shares held by VHCP EG.
(11)	The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $26.26 to $26.40 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.
(12)	Consists of (i) 1,765,404 shares held by VHCP3; (ii) 176,682 shares held by VHCP Co-3; (iii) 4,247,357 shares held by VHCP EG; and (iv) 651,790 shares held by VHCP XP.
(13)	Consists of (i) 4,001 shares held by VHCP3; (ii) 401 shares held by VHCP Co-3; and (iii) 4,402 shares held by VHCP EG.
(14)	The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $25.70 to $26.64 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.
(15)	Consists of (i) 1,769,405 shares held by VHCP3; (ii) 177,083 shares held by VHCP Co-3; (iii) 4,251,759 shares held by VHCP EG; and (iv) 651,790 shares held by VHCP XP.
(16)	Consists of (i) 91 shares held by VHCP3; (ii) 9 shares held by VHCP Co-3; and (iii) 100 shares held by VHCP EG.
(17)	The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $26.84 to $26.87 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.
(18)	Consists of (i) 1,769,496 shares held by VHCP3; (ii) 177,092 shares held by VHCP Co-3; (iii) 4,251,859 shares held by VHCP EG; and (iv) 651,790 shares held by VHCP XP.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.