Material Agreement, Termination of Material Agreement (Form 8-K)

Item 1.01

Entry into a Material Definitive Agreement.

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On March 31, 2025, MeiraGTx, LLC ("Tenant"), a Delaware limited liability company and a wholly-owned subsidiary of MeiraGTx Holdings plc, entered into a Lease Agreement (the "Lease") with ARE-East River Science Park, LLC (the "Landlord") for 14,235 square feet of laboratory and related office facilities at 450 East 29^th Street, New York, NY. The Lease is expected to commence on or prior to August 1, 2025 pending completion of the Landlord's work, but not before July 1, 2025 (the "Commencement Date"). Tenant shall not be obligated to pay the base rent for the applicable premises for four months after the Commencement Date and for the period beginning on the first anniversary of the Commencement Date and ending three months thereafter. The initial term of the Lease begins on the Commencement Date and ends seven years and seven months from the first day of the first full calendar month of the term of the Lease, and Tenant has an option to extend the Lease for an additional term of five years. As of the Commencement Date, the base rent under the Lease will be $111.00 per square foot per year, plus certain operating expenses and taxes. The base rent is subject to scheduled annual increases of 3% on the anniversary of the first day of the first full calendar month of the term of the Lease. In addition, the Landlord will contribute $50.00 per square foot toward the cost of construction and tenant improvements for the premises.

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The foregoing description of the terms of the Lease does not purport to be complete and is qualified in its entirety by reference to the full text of the Lease, which will be filed with the Company's Quarterly Report on Form 10-Q for the period ended March 31, 2025.

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Item 1.02Termination of a Material Definitive Agreement.

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In connection with entering into the Lease described in Item 1.01 of this Current Report on Form 8-K, which description is incorporated by reference into this Item 1.02, on April 2, 2025, Tenant elected to accelerate the termination of that certain Agreement of Sublease, dated May 31, 2019, between MeiraGTx, LLC and ImClone Systems, LLC (the "Sublease") relating to the office and laboratory space MeiraGTx, LLC currently occupies at 450 East 29^thStreet, New York, NY, which Sublease was scheduled to terminate on October 31, 2026. The Sublease is expected to terminate on or around August 31, 2025.

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