Additional Proxy Soliciting Materials (Form DEFA14A)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

SCHEDULE 14A

(Rule 14a-101)

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

(Amendment No. )

Check the appropriate box:

Biodesix, Inc.

(Name of Registrant as Specified in its Charter)

(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):

P.O. BOX 8016, CARY, NC 27512-9903 Your vote matters! Meeting Materials: Notice of Meeting and Proxy Statement & Annual Report on Form 10-K Important Notice Regarding the Availability Biodesix, Inc. of Proxy Materials For stockholders of record as of March 23, 2026 Annual Meeting of Stockholders To order paper materials, use one of the Tuesday, May 19, 2026 1:00 PM, Mountain Time Annual meeting to be held virtually via the internet - please visit www.proxydocs.com/BDSX for following methods. more details. You must register to attend the meeting online and/or participate at www.proxydocs.com/BDSX Internet: For a convenient way to view proxy materials, VOTE, and obtain www.investorelections.com/BDSX directions to attend the meeting go to www.proxydocs.com/BDSX To vote your proxy while visiting this site, you will need the 12 digit control number in the box below. Call: 1-866-648-8133 This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting. Email: [email protected] Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the If requesting material by e-mail, please send a blank e-mail with the internet. 12-digit control number (located below) in the subject line. No other requests, instructions OR other inquiries should be included with your If you want to receive a paper or e-mail copy of the proxy materials, you must request one. e-mail requesting material. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year's meeting, you must make this request on or before May 8, 2026. Your control number Have the 12-digit control number located in the box above available when you access the website and follow the instructions. SEE REVERSE FOR FULL AGENDA Copyright © 2026 BetaNXT, Inc. or its affiliates. All Rights Reserved

Biodesix, Inc. Annual Meeting of Stockholders THE BOARD OF DIRECTORS RECOMMENDS A VOTE: FOR ALL OF THE NOMINEES LISTED IN PROPOSAL 1 AND ON PROPOSALS 2 & 4 THE BOARD RECOMMENDS THAT AN ADVISORY VOTE ON THE COMPENSATION FOR NAMED EXECUTIVE OFFICERS BE HELD EVERY 1 YEAR ON PROPOSAL 3. PROPOSAL 1. To elect the two Class III directors named in this proxy statement to hold office until the 2029 annual meeting of stockholders; 1.01 Jean Franchi 1.02 Hany Massarany 2. To approve, on a non-binding advisory basis, the compensation of our named executive officers; 3. To approve, on a non-binding advisory basis, the frequency of solicitation of advisory votes to approve named executive officer compensation; 4. To ratify the appointment of KPMG LLP as our independent registered public accounting firm for the year ending December 31, 2026; NOTE: Such other business properly brought before the Annual Meeting, or any adjournment or postponement thereof.