CompleCure Partners with AGC Biologics’ Chiba Site to Develop Advanced Anti-Cancer Therapeutic Using Pioneering AMDC Technology

AGC Biologics announced today that the companyentered into a strategic service agreementwith CompleCure. The partnership focuseson developing the manufacturing process for a novel anti-cancer therapeutic, which usesAntibody Mimetics Drug Conjugate (AMDC) technology-a groundbreaking advancement in cancer treatment.

AGC Biologics is developing the manufacturing process for the protein component of this new therapeutic at its facility in Chiba, Japan. The AMDC technology represents a significant evolution of Antibody Drug Conjugate (ADC) therapy, offering a potentially promising new approach to cancer treatment by combining a mimetic protein structure with a chemically synthesized drug specifically designed to target and destroy cancer cells.

The therapeutic being developed by CompleCure aims to revolutionize breast cancer treatment. It is designed to achieve complete remission with minimal side effects, thereby significantly improving patient outcomes. The protein component, which is the focus of AGC Biologics' efforts, features a complex tetrameric structure that demands advanced technologies in microbial expression for successful process development and manufacturing-an area where AGC Biologics Chiba has unparalleled expertise.

"AGC Biologics Chiba and our scientists are experts in working with complex proteins and the latest technologies. For this reason, we are an ideal CDMO site to partner with CompleCure on this innovative treatment," said Jun Takami, General Manager, AGC Biologics Chiba Facility. "We look forward to working side by side with the CompleCure team to develop this new therapeutic that could have a revolutionary impact on breast cancer patients across the globe."

CompleCure selected AGC Biologics as its partner based on the company's 30-year track record as a leading CDMO, its ability to rapidly propose innovative development solutions, and its flexible production capabilities. The two companies plan to continue manufacturing the protein component at AGC Biologics' Chiba site,ensuring a seamless transition to production for further steps once the process development is completed.

This collaboration marks a significant milestone in the path toward the commercialization of AMDC-based therapeutics. By combining AGC Biologics' development and manufacturing capabilities with CompleCure's innovative therapeutic approach, the two companies hope to bring this promising treatment to market, ultimately contributing to the improvement of quality of life (QOL) for cancer patients worldwide.

For more information about AGC Biologics Chiba, visit www.agcbio.com/facilities/chiba. To learn more about AGC Biologics' global CDMO services go to www.agcbio.com.

About CompleCure

CompleCure is a start-up developing innovative pharmaceuticals by utilizing cutting-edge biotechnology. We own the intellectual property rights to the "Cupid-Psyche System," utilizing the high affinity and strong binding of proteins and vitamins. Cupid-Psyche System is one of the outcomes of the "Molecularly Designed Antibody Project," a cutting-edge R&D support program led by the Cabinet Office and involving Japan Bioindustry Association, the University of Tokyo, Osaka University, Chugai Pharmaceutical Co., Ltd. and Fujifilm Corporation. The new breast cancer treatment for which AGC would develop manufacturing process under the announced strategic service agreement is the most advanced in development among the AMDC based therapeutics utilizing the Cupid-Psyche system. This therapeutics is being developed in cooperation with the University of Tokyo, Tohoku University, and Chiba University. We will open up new possibilities for fundamental treatment of cancer.