Material Agreement, Management Change/Compensation, Termination of Material Agreement (Form 8-K)

Amendment to Employment Agreements

On October 17, 2025, Rezolute, Inc. (the "Company"), Nevan C. Elam, the Company's Chief Executive Officer, Brian Roberts, the Company's Chief Medical Officer, Daron Evans, the Company's Chief Financial Officer and Sunil Karnawat, the Company's Chief Commercial Officer each entered into amendments to their respective employment agreements to entitle each to a full gross-up payment (the "Gross-up Payment") for any excise tax and other local, state and federal taxes imposed as a result of any excess parachute payment to be paid in connection with a change of control event as determined under Section 280G of the Internal Revenue Code. The determination of the Gross-Up Payment amount will be made by the Company in its sole discretion. The terms of the respective employment agreements remain unchanged and the amendments will be filed with the Company's next Quarterly Report on Form 10-Q.