09/18/2025 | Press release | Distributed by Public on 09/17/2025 22:06
NCHS Data Brief No. 540, September 2025
PDF Version (673 KB)
Catharine A. Couch, Ph.D., R.D., Rina Mascarenhas, B.S., Bryan Stierman, M.D., M.P.H., and Cheryl D. Fryar, M.S.P.H.
Data from the National Health and Nutrition Examination Survey
Heart disease is the leading cause of mortality in the United States (1,2). The American Heart Association's "Life's Essential 8" (LE8) is a metric with four behavioral factors and four health factors used to assess cardiovascular health (3,4). Blood pressure, blood lipids, blood glucose, and body mass index (BMI), the four health factors of LE8, are cardiovascular disease (CVD) risk factors. Having a greater number of these CVD risk factors is associated with increased risk of CVD and all-cause mortality (3,5). This report presents prevalence estimates for none, one, or two or more of these CVD risk factors (uncontrolled high blood pressure, uncontrolled high blood lipids, uncontrolled high mean blood glucose as measured with hemoglobin A1c, and high BMI) in U.S. adults during August 2021-August 2023.
Keywords: heart disease, blood pressure, lipids, glucose, National Health and Nutrition Examination Survey (NHANES)
Number of CVD risk factors and sex | Sample size | Percent | Standard error |
No CVD risk factors | |||
All | 5,249 | 36.4 | 1.4 |
Men | 2,396 | 34.9 | 1.0 |
Women | 2,853 | 37.8 | 2.2 |
One CVD risk factor | |||
All | 5,249 | 34.9 | 0.9 |
Men | 2,396 | 33.4 | 1.3 |
Women | 2,853 | 36.4 | 1.3 |
Two or more CVD risk factors | |||
All | 5,249 | 28.7 | 1.0 |
Men | 2,396 | 131.7 | 1.4 |
Women | 2,853 | 25.8 | 1.5 |
1Significantly different from women (p < 0.05).
NOTE: Cardiovascular disease (CVD) risk factors include systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 mm Hg; non-high-density lipoprotein cholesterol ≥ 190 mg/dL; A1c ≥ 6.5%; and body mass index ≥ 30.
SOURCE: National Center for Health Statistics, National Health and Nutrition Examination Survey, August 2021-August 2023.
Number of CVD risk factors and age group | Sample size | Percent | Standard error |
No CVD risk factors | |||
20-39 | 1,283 | 53.7 | 2.3 |
40-59 | 1,542 | 29.6 | 1.6 |
60 and older | 2,424 | 124.7 | 1.3 |
One CVD risk factor | |||
20-39 | 1,283 | 27.0 | 1.8 |
40-59 | 1,542 | 35.9 | 1.4 |
60 and older | 2,424 | 242.6 | 1.2 |
Two or more CVD risk factors | |||
20-39 | 1,283 | 319.3 | 1.4 |
40-59 | 1,542 | 34.5 | 1.2 |
60 and older | 2,424 | 32.7 | 1.8 |
1Significant decreasing linear trend with age (p < 0.05).
2Significant increasing linear trend with age (p < 0.05).
3Significantly different from ages 40-59 and 60 and older (p < 0.05).
NOTE: Cardiovascular disease (CVD) risk factors include systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 mm Hg; non-high-density lipoprotein cholesterol ≥ 190 mg/dL; A1c ≥ 6.5%; and body mass index ≥ 30.
SOURCE: National Center for Health Statistics, National Health and Nutrition Examination Survey, August 2021-August 2023.
Number of CVD risk factors and family income level | Sample size | Percent | Standard error |
No CVD risk factors | |||
Less than 130% FPL | 924 | 32.9 | 2.2 |
130%-349% FPL | 1,742 | 33.3 | 1.8 |
350% FPL or more | 1,916 | 138.9 | 2.1 |
One CVD risk factor | |||
Less than 130% FPL | 924 | 35.7 | 1.6 |
130%-349% FPL | 1,742 | 34.1 | 1.1 |
350% FPL or more | 1,916 | 36.4 | 1.5 |
Two or more CVD risk factors | |||
Less than 130% FPL | 924 | 31.3 | 1.7 |
130%-349% FPL | 1,742 | 32.6 | 1.4 |
350% FPL or more | 1,916 | 124.7 | 1.7 |
1Significantly different from less than 130% FPL and 130%-349% FPL (p < 0.05).
NOTES: Cardiovascular disease (CVD) risk factors include systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 mm Hg; non-high-density lipoprotein cholesterol ≥ 190 mg/dL; A1c ≥ 6.5%; and body mass index ≥ 30. Family income is a percentage of the federal poverty level (FPL). Income levels are defined by FPL; 12.8% are missing income information.
SOURCE: National Center for Health Statistics, National Health and Nutrition Examination Survey, August 2021-August 2023.
Survey year | Sample size | No CVD risk factors | One CVD risk factor |
Two or more CVD risk factors |
|||
Percent | Standard error | Percent | Standard error | Percent | Standard error | ||
2013-2014 | 5,054 | 42.1 | 0.9 | 34.1 | 0.8 | 23.7 | 0.4 |
2015-2016 | 4,916 | 37.8 | 1.4 | 36.5 | 0.8 | 25.8 | 0.9 |
2017-March 2020 | 7,026 | 36.1 | 1.3 | 37.2 | 0.8 | 26.7 | 1.2 |
August 2021-August 2023 | 5,249 | 138.0 | 1.4 | 133.9 | 1.0 | 228.1 | 1.0 |
1Significant quadratic trend (p < 0.05).
2Significant increasing linear trend (p < 0.05).
NOTES: Cardiovascular disease (CVD) risk factors include systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 mm Hg; non-high-density lipoprotein cholesterol ≥ 190 mg/dL; A1c ≥ 6.5%; and body mass index ≥ 30. Estimates are age adjusted by the direct method to the U.S. Census 2000 population using age groups 20-39, 40-59, and 60 and older.
SOURCE: National Center for Health Statistics, National Health and Nutrition Examination Survey, 2013-2014 through August 2021-August 2023.
During August 2021-August 2023, nearly two-thirds of adults in the United States had at least one CVD risk factor (uncontrolled high blood pressure, uncontrolled high blood lipids, uncontrolled high mean blood glucose, or high BMI), and differences were observed by sex, age group, and family income. Men were more likely to have two or more CVD risk factors compared with women. The percentage of adults with two or more CVD risk factors was higher among older age groups. The percentage of adults with no CVD risk factors was highest and the percentage of adults with two or more CVD risk factors was lowest among those in the highest income category. From 2013-2014 to August 2021-August 2023, the percentage of adults with two or more CVD risk factors increased.
Continued monitoring of the prevalence of CVD risk factors will provide information on the cardiovascular health of adults in the United States.
Uncontrolled high blood pressure: A measured systolic blood pressure of 130 mm Hg or more or a diastolic blood pressure of 80 mm Hg or more (6), based on the average of three measurements. People defined as having high blood pressure may or may not have been taking medication to lower their blood pressure.
Uncontrolled high blood lipids: Non-high-density lipoprotein cholesterol greater than or equal to 190 mg/dL (3,7). People defined as having high blood lipids may or may not have been taking cholesterol-lowering medication.
Uncontrolled high mean blood glucose: Hemoglobin A1c greater than or equal to 6.5% (8). People defined as having high blood glucose may or may not have been taking medication to control blood glucose.
High body mass index (BMI): Calculated as weight in kilograms divided by height in meters squared. High BMI is defined as BMI of 30.0 or more, corresponding with the definition of obesity (3,9).
Federal poverty level (FPL): The ratio of annual family income to the federal poverty guidelines, expressed as a percentage. Federal poverty guidelines are defined by the U.S. Department of Health and Human Services to account for inflation, family size, and geographic location (10).
The National Health and Nutrition Examination Survey (NHANES) is a cross-sectional, nationally representative sample of the U.S. civilian noninstitutionalized population. NHANES consists of home interviews and health examinations and laboratory tests in mobile examination centers. The sample is selected through a complex, multistage probability design. NHANES was conducted continuously from 1999 through March 2020, when data collection was paused due to the COVID-19 pandemic. In August 2021, NHANES resumed data collection with revised operations and procedures. Details on these changes can be found elsewhere (11).
In the present analysis, data from the August 2021-August 2023 NHANES were used to estimate the prevalence of no, one, and two or more CVD risk factors and to test for differences between subgroups. Four NHANES cycles (2013-2014, 2015-2016, 2017-March 2020, and August
2021-August 2023) were used to assess trends in the prevalence of no, one, and two or more CVD risk factors.
All participants age 20 and older with complete CVD risk factor data (blood pressure, blood lipids, mean blood glucose as measured with hemoglobin A1c, and BMI) were included. Pregnant women were excluded. Prevalence estimates were weighted using phlebotomy (blood draw) sample weights for August 2021-August 2023 and examination sample weights for cycles 2013-2014, 2015-2016, and 2017-March 2020 to account for the survey's complex, multistage probability design. Sample sizes are unweighted. Standard errors of prevalence estimates were calculated using Taylor series linearization. For August 2021-August 2023, differences in estimates between subgroups were tested using t tests. Polynomial regression models were used to test for linear and quadratic trends, accounting for unequal spacing and lengths of survey cycles. Statistical significance was set at p < 0.05 level. Statistical analyses were conducted using R version 4.4.1 and the R survey package.
Catharine A. Couch, Rina Mascarenhas, Bryan Stierman, and Cheryl D. Fryar are with the National Center for Health Statistics, Division of Health and Nutrition Examination Surveys.
Couch CA, Mascarenhas R, Stierman B, Fryar CD. Prevalence of cardiovascular disease risk factors in adults: United States, August 2021-August 2023. NCHS Data Brief. 2025 Sep;(540):1-9. DOI: https://dx.doi.org/10.15620/cdc/174623.
All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.
Brian C. Moyer, Ph.D., Director
Amy M. Branum, Ph.D., Associate Director for Science
Alan E. Simon, M.D., Director
Lara J. Akinbami, M.D., Associate Director for Science