Failure to Satisfy Listing Rule (Form 8-K)

Item 3.01 - Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

On October 8, 2025, Milestone Scientific Inc. ("the Company") received a letter from NYSE American LLC ("NYSE American" or the "Exchange") stating that the Company is not in compliance with the continued listing standards as outlined in Section(s) 1003(a)(ii), and (iii) of the NYSE American Company Guide (the "Company Guide"). To maintain its listing, the Company must submit a plan of compliance by November 7, 2025, outlining the actions it has taken or will take to regain compliance. If the plan is accepted, the Company may be able to continue its listing but will be subject to periodic reviews by the Exchange. If the plan is not accepted or if it is accepted but the Company fails to comply with the continued listing standards by April 8, 2027, or if the Company does not make progress consistent with the plan, the Exchange will initiate delisting procedures as appropriate. The Company's management is pursuing options to address the deficiency and intends to submit a compliance plan on or before the deadline set by the Exchange.