Material Agreement (Form 8-K)

Item 1.01 Entry into a Material Definitive Agreement.

Third Amendment to Loan and Security Agreement

On September 30, 2025 (the "Amendment Date"), Sight Sciences, Inc. (the "Company") entered into a third amendment (the "Amendment") to its Loan and Security Agreement (as amended, the "Hercules Loan Agreement") with Hercules Capital, Inc. ("Hercules") and certain of its affiliates (collectively with Hercules, the "Lenders") entered into in January 2024. The Hercules Loan Agreement provides for a senior secured term loan facility in the aggregate principal amount of up to $65.0 million. The Amendment was approved by all of the Lenders.

The Amendment amends the Hercules Loan Agreement to provide for an additional six-month extension of the interest only period, to now extend to February 1, 2027.

The Hercules Loan Agreement provided for the availability of additional tranches to the Company, contingent upon the achievement of certain performance milestones. The Amendment amends the Hercules Loan Agreement to reallocate an undrawn and unavailable $10.0 million tranche by increasing from $15.0 million to $25.0 million the amount available to draw through the interest only period in minimum increments of $5.0 million, subject to the sole approval of Hercules' investment committee, maintaining the maximum $65.0 million credit facility.

Pursuant to the Amendment, as consideration for the above amendments to the Hercules Loan Agreement, the Company paid Hercules a fee of $50,000, for the benefit of the lenders, plus certain costs and expenses.

The description of the Amendment does not purport to be complete and is qualified in its entirety by reference to the full text of the Amendment, a copy of which is attached as Exhibit 10.1 to this Current Report on Form 8-K (this "Current Report") and is incorporated herein by reference.