Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Crouse Steven C. 2. Issuer Name and Ticker or Trading Symbol BIO-TECHNE Corp [TECH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President - Diag & Spatial Bi (Last) (First) (Middle) 614 MCKINLEY PLACE NE 3. Date of Earliest Transaction (Month/Day/Year) 03/02/2026 (Street) MINNEAPOLIS, MN 55413 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 5,894 D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Restricted Stock Units	(1)							(2)	(2)	Common Stock	1,588		1,588	D
Restricted Stock Units	(1)							(3)	(3)	Common Stock	1,800		1,800	D
Restricted Stock Units	(1)							(4)	(4)	Common Stock	1,379		1,379	D
Restricted Stock Units	(1)							(5)	(5)	Common Stock	3,737		3,737	D
Restricted Stock Units	(1)							(6)	(6)	Common Stock	6,529		6,529	D
Stock Option (right to buy)	$97.13							(7)	04/01/2028	Common Stock	3,856		3,856	D
Stock Option (right to buy)	$120.46							(7)	08/06/2028	Common Stock	19,032		19,032	D
Stock Option (right to buy)	$94.52							(8)	08/15/2029	Common Stock	24,560		24,560	D
Stock Option (right to buy)	$84.61							(9)	08/15/2030	Common Stock	12,649		12,649	D
Stock Option (right to buy)	$73.46							(10)	05/01/2031	Common Stock	7,327		7,327	D
Stock Option (right to buy)	$74.91							(11)	08/15/2034	Common Stock	17,133		17,133	D
Stock Option (right to buy)	$48.61							(12)	06/02/2035	Common Stock	5,434		5,434	D
Stock Option (right to buy)	$53.6							(13)	08/15/2035	Common Stock	19,151		19,151	D
Performance Restricted Stock Units	(1)	03/02/2026		A		2,387		(14)	(14)	Common Stock	2,387	$ 0	2,387	D
Restricted Stock Units	(1)	03/02/2026		A		735		(15)	(15)	Common Stock	735	$ 0	735	D
Stock Option (right to buy)	$57.82	03/02/2026		A		1,911		(16)	03/02/2036	Common Stock	1,911	$ 0	1,911	D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Crouse Steven C. 614 MCKINLEY PLACE NE MINNEAPOLIS, MN 55413			President - Diag & Spatial Bi

Signatures

/s/ Andrew Nick as Attorney-in-Fact for Steven C. Crouse pursuant to Power of Attorney previously filed.		03/04/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock.
(2)	794 restricted stock units vest on 5/1/2026 and 5/1/2027.
(3)	600 restricted stock units vest on each of 6/2/2026, 6/2/2027 and 6/2/2028.
(4)	1,379 restricted stock units vest on 8/15/2026.
(5)	1,868 restricted stock units vest on 8/15/2026 and 1,869 restricted stock units vest on 8/15/2027.
(6)	2,176 restricted stock units vest on each of 8/15/2026 and 8/15/2028; and 2,177 restricted stock units vest on 8/15/2027.
(7)	100% vested.
(8)	Options to purchase 6,140 shares vest on each of 8/15/2023, 8/15/2024, 8/15/2025 and 8/15/2026.
(9)	Options to purchase 3,162 shares vest on each of 8/15/2024, 8/15/2026 and 8/15/2027; and options to purchase 3,163 shares vest on 8/15/2025.
(10)	Options to purchase 1,832 shares vest on each of 5/1/2025, 5/1/2026 and 5/1/2028; and options to purchase 1,831 shares vest on 5/1/2027.
(11)	Options to purchase 4,283 shares vest on each of 8/15/2025, 8/15/2027 and 8/15/2028; and options to purchase 4,284 shares vest on 8/15/2026.
(12)	Options to purchase 1,359 shares vest on each of 6/2/2026 and 6/2/2028; and options to purchase 1,358 shares vest on each of 6/2/2027 and 6/2/2029.
(13)	Options to purchase 4,788 shares vest on each of 8/15/2026, 8/15/2027 and 8/15/2029; and options to purchase 4,787 shares vest on 8/15/2028.
(14)	Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator).
(15)	245 restricted stock units vest on 3/2/2027, 3/2/2028 and 3/2/2029.
(16)	Options to purchase 478 shares vest on each of 3/2/2027, 3/2/2028 and 3/2/2030; and options to purchase 477 shares vest on 3/2/2029.

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