Item 1.01. Entry into a Material Definitive Agreement.

On January 12, 2026, CVRx, Inc. (the "Company") entered into an Open Market Sale Agreement^SM (the "Sale Agreement") with Jefferies LLC (the "Agent"). Pursuant to the terms of the Sale Agreement, the Company may offer and sell shares of the Company's common stock, $0.01 par value per share (the "Shares"), having an aggregate offering amount of up to $50.0 million from time to time through the Agent. The Agent will use its commercially reasonable efforts, subject to the terms of the Sale Agreement, to sell the Shares offered. Sales of the Shares, if any, may be made in sales deemed to be an "at-the-market offering" as defined in Rule 415 under the Securities Act of 1933, as amended (the "Securities Act"). The Agent will be entitled to a commission from the Company of up to 3.0% of the gross proceeds from the sale of Shares sold under the Sale Agreement. In addition, the Company has agreed to pay certain expenses incurred by the Agent in connection with the offering. The Company intends to use any net proceeds from the offering for working capital and general corporate purposes.

The Shares will be sold pursuant to the Company's registration statement on Form S-3 (File No. 333-291309), including the related prospectus, that was filed with the Securities and Exchange Commission, and declared effective on December 15, 2025, as supplemented by a prospectus supplement dated January 12, 2026. This Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state.

The Sale Agreement contains customary representations, warranties, and agreements of the Company and the Agent, indemnification rights and obligations of the parties and termination provisions. The Company is not obligated to make any sales of Shares under the Sale Agreement. The offering of the Shares pursuant to the Sale Agreement will terminate upon the end of the Agency Period (as defined in the Sale Agreement) unless earlier terminated by the parties to the Sale Agreement in accordance with its terms. The foregoing description of the Sale Agreement does not purport to be complete and is qualified in its entirety by reference to the Sale Agreement, which is filed as Exhibit 1.1 to this Current Report on Form 8-K and incorporated herein by reference.

A copy of the opinion of Faegre Drinker Biddle & Reath LLP, counsel to the Company, relating to the legality of the Shares is filed as Exhibit 5.1 to this Current Report on Form 8-K.