George Mason public health researchers enter new phase of NIH funded research

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Dr. Kathi Huddleston, PhD, MSN

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Scientists, nurses, and researchers in George Mason University's College of Public Health(CPH) have successfully progressedto the third phase of a National Institutes of Health (NIH) program studying a broad range of early life exposures on child health.

The NIH grant provides more than $157 million in awards for Environmental Influences on Child Health Outcomes(ECHO), and George Mason will receive $1.35 million annually until 2030 to conduct the study.

ECHO researcher working with one of the participants in the Population Health Center. Photo by Evan Cantwell/Office of University Branding.

George Mason is one of 45 research sites across the country gathering longitudinal data on more than 30,000 children; 1,059 of those children are enrolled in George Mason's ECHO program. The research is conducted in George Mason's Population Health Center, the only clinical site in Virginia.

"For this phase of ECHO, we're gathering information on novel chemical exposures, preconception behaviors, early exposures, and the consequences of regional and social determinants of health," said Kathi Huddleston, PhD '08, principal investigator and CPH associate professor. "Following our large and diverse ECHO population will enhance the ability to go from society to biology to more positive health outcomes."

George Mason faculty and students working on the project include alumni Grace Lawrence, PhD '18, Daisy Posada, MA '18, Megan Bayne, MA '18, Shiva Zarean, BS '24, and Alma Fuller, Lynda Ashie, and Bruna Mayen, a senior biology major who also acts as the project and lab manager.

The project has followed these families since their 2012 to 2019 pregnancy.

"Many of the families sharing their health information to help the next generation include George Mason alumni," Huddleston added.

While the project tracks changes in child health over time, the study had to adapt during the pandemic when researchers moved to remote data collection. Since then, ECHO has been instrumental in advancing remote research study activities.

ECHO researcher working with one of the participants in the Population Health Center. Photo by Evan Cantwell/Office of University Branding.

"When the kids were babies, we received surveys and sample kits in the mail to provide teeth and hair samples that we would send back. Now we come into the center once a year for check-ups," said Susy Ashkar, a mother of three boys, ages 9, 6, and 4, who participate in the ECHO study.

"After quality assurance and review determined the validity and veracity of the data, we are now continuing many of these remote practices to decrease the study burden on our families," said Huddleston.

This has added to Mayen's role as lab manager as she collects teeth and hair samples as well as basic anthropometric measurements to assess the health and well-being of our children as they grow.

"As a biobank, we provide high-quality, well-documented biological samples ensuring they remain viable and uncontaminated, for long-term preservation under controlled conditions so they can be used for future analyses, thereby serving as a research-enabling platform that advances science," said Mayen.

"From the research we've conducted during this phase, we can see that groups of children who share a common characteristic or experience. For example, those born in the same year give us the advantage to see development and change over time, help identify patterns, trends, and predictors. All that is possible because of the work we do every day in collecting biospecimens, anthropometrics, and many surveys in the participating ECHO families," Mayen said.

"We have tapped on a wonderful resource of families willing to share of their time to help science to improve population health, and in that act are demonstrating to their children that citizen science matters," Huddleston said. "I can't wait to see some of these young ECHO participants enroll at George Mason and bring with them that spirit of public health."