Material Agreement (Form 8-K)

Item 1.01. Entry into a Material Definitive Agreement.

On March 20, 2026, Profusa, Inc. (the "Company") entered into an amendment (the "Amendment") to the Amended and Restated Promissory Note, dated May 31, 2024 (the "Promissory Note"), issued by the Company (formerly known as NorthView Acquisition Corporation) to NorthView Sponsor I LLC. Pursuant to the Amendment, the maturity date of the Promissory Note was extended to December 31, 2026.

The foregoing description of the Amendment is a summary only, does not purport to be complete, and is qualified in its entirety by reference to the full text of the agreement, a copy of which is filed herewith as Exhibit 10.1 and is incorporated herein by reference.