Proxy Statement (Form 8-K)

The board of directors (the "Board") of Predictive Oncology, a Delaware corporation (the "Company"), has determined that the Company's 2025 annual meeting of stockholders (the "Annual Meeting") will be held on November 25, 2025, at the offices of DLA Piper LLP (US) at 1001 Liberty Avenue, Suite 500, Pittsburgh, Pennsylvania 15222. The record date for determining stockholders entitled to notice of, and to vote at, the Annual Meeting will be October 24, 2025.

The Annual Meeting is more than 30 days from the date of the Company's 2024 annual meeting of stockholders. In accordance with the Company's bylaws and the rules and regulations of the Securities and Exchange Commission, stockholders will have until October 26, 2025 (the "Proposal Deadline") to submit stockholder proposals and request proxy access with respect to any business to be considered at the Annual Meeting. To be eligible for inclusion, any such proposal should be directed to the following address:

Predictive Oncology Inc.

Attention: Secretary

91 43rd Street, Suite 110

Pittsburgh, Pennsylvania 15201

The Company anticipates mailing definitive proxy materials for the Annual Meeting on or about November 3, 2025. Under the rules and regulations of the Securities and Exchange Commission, the Company undertakes to supplement such materials (and, if necessary, postpone the Annual Meeting) to address any stockholder proposals timely received before the Proposal Deadline.