Telomir Pharmaceuticals Inc.

05/07/2025 | Press release | Distributed by Public on 05/07/2025 05:30

Material Event (Form 8-K)

Item 8.01 Other Events

Telomir Pharmaceuticals Demonstrates Telomir-1 Reverses Key Drivers of Cellular Decline in Human Cell Lines Supporting Therapeutic Potential in Autism and Spasmodic Dysphonia

Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ("Telomir"), a leader in age-reversal science, today announced new preclinical data showing that its lead oral drug candidate, Telomir-1, reverses multiple hallmarks of cellular decline across several human cell lines. The findings include improved mitochondrial activity, reduced oxidative stress, restored calcium balance, and protection from toxic metal effects-offering a mechanistic foundation for the Company's new research initiatives in autism spectrum disorder (ASD) and spasmodic dysphonia (SD).

The in vitro studies, conducted in collaboration with SmartAssays, demonstrated Telomir-1's ability to:

● Improve cell viability under stress, particularly in dividing cell populations.
Maintaining cell survival is critical for tissue repair, immune defense, and slowing the progression of degenerative conditions.
● Boost mitochondrial function, indicating stronger energy production.
Healthy mitochondria are essential for powering cells and preventing energy loss that drives aging and diseases like Alzheimer's, Parkinson's, and autism.
● Reduce reactive oxygen species (ROS), limiting oxidative damage.
Excess ROS contributes to DNA damage, inflammation, neurodegeneration and cell death, all of which accelerate aging and chronic diseases.
● Restore calcium signaling, helping maintain healthy cellular functions and communication.
Disrupted calcium balance impairs brain, muscle, and heart function and is a known trigger of cellular death and neurodegeneration.
● Protect cells from metal-induced toxicity, including iron and copper-both linked to ROS formation, calcium dysregulation and accelerated cellular aging and death.
Iron and copper accumulation drive oxidative stress and mitochondrial failure.

These results suggest that Telomir-1 may address fundamental cellular stress mechanisms associated with aging and chronic disease.

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