Insight Guru Inc.
10/06/2026 | Press release | Distributed by Public on 10/05/2026 23:45
Market Movers | Winners: PTC, PCVX, RXO | Losers: SPHR, CAPR, CHRW
The S&P 500 rose 0.7% on Monday, October 5, while the Nasdaq-100 gained 0.9% and the Dow Jones Industrial Average inched up 0.2%. The S&P 500 is now up 1.2% over five trading days and up 0.3% over the past month.
Within the Trefis coverage universe, 1,995 stocks rose and 2,101 fell. At the extremes, PTC gained 33.5% and Sphere Entertainment (SPHR) fell 13.6%.
Monday's Market Winners
The 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the highest returns on Monday:
| # | Ticker | Company Name |
1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | PTC | PTC | 33.5% | 10.4% |
| 2 | PCVX | Vaxcyte | 30.7% | 60.0% |
| 3 | RXO | RXO | 22.5% | 126.7% |
| 4 | DNA | Ginkgo Bioworks | 21.3% | 80.3% |
| 5 | NVAX | Novavax | 20.1% | 86.9% |
| 6 | RXRX | Recursion Pharmaceuticals | 16.0% | 16.9% |
| 7 | EBS | Emergent BioSolutions | 14.4% | -41.4% |
| 8 | PACB | Pacific Biosciences of California | 13.0% | 53.5% |
| 9 | QDEL | QuidelOrtho | 12.7% | -57.5% |
| 10 | ARCT | Arcturus Therapeutics | 12.5% | 139.2% |
Monday's Market Losers
And the 10 US-listed stocks in the Trefis coverage universe worth at least $300 million with the lowest returns on Monday:
| # | Ticker | Company Name |
1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | SPHR | Sphere Entertainment | -13.6% | 16.5% |
| 2 | CAPR | Capricor Therapeutics | -13.1% | n/a |
| 3 | CHRW | C.H. Robinson Worldwide | -10.8% | -11.6% |
| 4 | SECZ | Securitize | -9.9% | n/a |
| 5 | PGEN | Precigen | -9.4% | 85.2% |
| 6 | AADX | Applied Aerospace & Defense | -8.9% | n/a |
| 7 | ACMR | ACM Research | -8.6% | 93.1% |
| 8 | HYLN | Hyliion | -8.6% | 125.0% |
| 9 | DFH | Dream Finders Homes | -8.1% | -42.2% |
| 10 | YSS | York Space Systems | -7.5% | n/a |
For A Few Names, Monday Extended A Monthly Trend
The 21.3% gain in Ginkgo Bioworks (DNA) on Monday was not a one-off: the stock is up 115.5% over the past month, and up 77.7% over the sessions before Monday.
Pacific Biosciences of California (PACB) appears on both the one-day and one-month winners lists. It rose 13.0% on Monday and is up 120.8% over the past month; excluding Monday, it had already gained 95.4% over the other sessions.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name |
1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | PACB | Pacific Biosciences of California | 67.8% | 53.5% |
| 2 | DNA | Ginkgo Bioworks | 43.2% | 80.3% |
| 3 | RXO | RXO | 42.2% | 126.7% |
| 4 | OPTX | Syntec Optics | 38.2% | 242.7% |
| 5 | PTC | PTC | 37.6% | 10.4% |
| 6 | RXRX | Recursion Pharmaceuticals | 29.2% | 16.9% |
| 7 | IOVA | Iovance Biotherapeutics | 28.8% | 418.3% |
| 8 | PCVX | Vaxcyte | 26.7% | 60.0% |
| 9 | AAOI | Applied Optoelectronics | 25.6% | 248.7% |
| 10 | AZTA | Azenta | 24.8% | 28.5% |
Losers
| # | Ticker | Company Name |
1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | LQDA | Liquidia | -62.5% | -19.9% |
| 2 | QURE | uniQure | -41.7% | -4.7% |
| 3 | EMAT | Evolution Metals & Technologies | -35.8% | n/a |
| 4 | NKTR | Nektar Therapeutics | -30.1% | -0.1% |
| 5 | SECZ | Securitize | -29.6% | n/a |
| 6 | QNC | Quantum eMotion | -25.5% | n/a |
| 7 | CLPT | ClearPoint Neuro | -24.8% | -15.8% |
| 8 | KDK | Kodiak AI | -23.8% | -84.2% |
| 9 | GLAS | Glass House Brands | -21.9% | n/a |
| 10 | ACRS | Aclaris Therapeutics | -21.4% | 41.9% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name |
1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | PACB | Pacific Biosciences of California | 120.8% | 53.5% |
| 2 | DNA | Ginkgo Bioworks | 115.5% | 80.3% |
| 3 | GRAL | GRAIL | 91.1% | n/a |
| 4 | BNC | BNB Standard | 84.5% | -5.5% |
| 5 | MXL | MaxLinear | 77.4% | 505.2% |
| 6 | VICR | Vicor | 71.0% | 178.8% |
| 7 | SVIA | Silvia | 70.0% | n/a |
| 8 | SECZ | Securitize | 64.8% | n/a |
| 9 | IOVA | Iovance Biotherapeutics | 62.6% | 418.3% |
| 10 | COHU | COHU | 60.4% | 216.8% |
Losers
| # | Ticker | Company Name |
1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | LQDA | Liquidia | -59.7% | -19.9% |
| 2 | KDK | Kodiak AI | -53.0% | -84.2% |
| 3 | QURE | uniQure | -49.2% | -4.7% |
| 4 | NKTR | Nektar Therapeutics | -44.7% | -0.1% |
| 5 | CABA | Cabaletta Bio | -40.2% | -5.0% |
| 6 | ALMS | Alumis | -39.8% | -29.9% |
| 7 | FICO | Fair Isaac | -38.4% | -59.2% |
| 8 | DYN | Dyne Therapeutics | -38.1% | -21.1% |
| 9 | SWRD | Stewards | -38.0% | -54.1% |
| 10 | XENE | Xenon Pharmaceuticals | -37.8% | -16.2% |
Today's Winner Is Tomorrow's Loser Often Enough
The movers list is the most honest picture of single-stock risk the market prints each day: the same volatility that makes the winners column also fills the losers column, and no one reliably knows which side a stock lands on next.
That is the case for owning a disciplined basket instead of chasing the tape. The Trefis High Quality (HQ) Portfolio holds roughly 30 businesses selected for consistent cash generation, strong margins, and resilient balance sheets, sized and rebalanced with rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Watch the movers for information; let the portfolio do the compounding.
Insight Guru Inc. published this content on October 06, 2026, and is solely responsible for the information contained herein. Distributed via Public Technologies (PUBT), unedited and unaltered, on October 06, 2026 at 05:45 UTC. If you believe the information included in the content is inaccurate or outdated and requires editing or removal, please contact us at [email protected]