What Frontier healthcare leaders are doing differently with AI

AI is no longer a side experiment in healthcare. It's showing up in exam rooms, call centers, revenue cycles, and security operations. But what's becoming clear is this: some organizations are redesigning how work gets done, and others are still running pilots.

Research we conducted with senior healthcare executives in the United States, published in the New England Journal of Medicine, revealed a growing readiness divide. As some systems build governance, security, and workforce models to scale AI safely, others are still in proof-of-concept mode. The result? Diverging outcomes in productivity, workforce strain, cost-to-serve, and resilience.

The question is no longer whether AI belongs in healthcare. It's how quickly organizations can operationalize it-safely, responsibly, and at scale.

Microsoft works with more than 170,000 healthcare customers globally to move from pilot to production with enterprise-grade security, privacy, and compliance.

So what does Frontier Transformation actually look like? The following examples show how healthcare organizations are embedding AI into core workflows-moving beyond pilots to deliver real, scalable impact with the governance and trust required in clinical environments.

Accelerating discovery and clinical development with AI

Frontier organizations are reinventing discovery by treating AI as an always-on research partner. It compresses the time it takes to find, synthesize, and act on evidence across functions. The result isn't just faster tasks; it's faster decisions and a more scalable path from insight to impact. As these capabilities become table stakes, organizations that can't industrialize knowledge of work will fall behind in speed-to-trial, speed-to-market, and ultimately speed-to-patient.

UCB: Scaling agent-based AI with a secure internal platform

UCB built SKAI, a secure internal platform on Microsoft Azure for generative and agent-based AI, helping teams apply knowledge faster and operationalize AI with governance built in.

Syneos Health: Streamlining complex data to bring therapies to patients faster

Syneos Health is using AI to help teams analyze large, complex data sets across the clinical development lifecycle. With faster, more consistent synthesis of study inputs and operational signals, biopharma customers can make decisions with greater speed and confidence. Syneos Health reported reducing time for clinical trial site activation by about 10%, helping remove friction from a critical step in getting lifesaving therapies to patients. Enhanced predictive modeling and forecasting tools also allow teams to identify risks earlier, model scenarios, and engage customers and clinical partners more effectively.

Advancing care delivery with AI in the flow of clinical work

In care delivery, transformation happens when AI shows up in the flow of work. It reduces cognitive and documentation load and gives time back to clinicians. Frontier organizations use AI to shift capacity toward patients, not screens, while improving consistency and quality. As patient expectations rise and workforce shortages persist, the ability to deliver more care with the same (or fewer) resources is quickly becoming a differentiator.

Intermountain Health: Rehumanizing care by reducing documentation burden

Intermountain Health adopted Microsoft Dragon Copilot to reduce the administrative load that can pull clinicians away from patients. By supporting clinical documentation and automating routine tasks, clinicians at Intermountain Health reported experiencing a 27% reduction in time spent on notes per appointment, reducing cognitive burden and enabling more meaningful patient engagement by incorporating AI as a core part of their clinical workflow.

Cooper University Health Care: Giving clinicians time back in the flow of care

Cooper University Health Care is using AI-powered clinical documentation to reduce the administrative burden that pulls clinicians away from patients. By embedding AI directly into clinical workflows, clinicians at Cooper reported saving more than four minutes per patient visit on documentation, experiencing less burnout, and engaging more meaningfully with patients-demonstrating how AI optimized workflows can rehumanize care at scale.

Mercy: Bringing ambient AI to nursing workflows

Nurses are at the center of care delivery and often at the center of documentation burden. Mercy has been using AI capabilities to transform nursing care. By capturing and structuring information in the flow of work, Mercy reported 8 to 24 minutes saved per shift for high-use nurses, a 21% reduction in documentation latency and a 4.5% increase in patient satisfaction from their initial rollout.

Streamlining operations and experiences across the healthcare organization

Frontier Transformation requires more than point solutions. It takes an AI-ready operating foundation that connects people, processes, and data across the organization. Frontier organizations use copilots and agents to standardize work, automate routine interactions, and deliver more consistent experiences at scale. Those that treat AI as isolated experiments often find themselves outpaced by peers who can improve service levels while bending the cost curve.

Bupa APAC: Building an AI-ready foundation to improve customer experiences

Bupa APAC is streamlining operations, automating routine processes, and making customer experiences more seamless thanks to AI. With an emphasis on AI readiness-skills, governance, and secure access to information-Bupa APAC upskilled its workforce with Microsoft 365 Copilot and GitHub Copilot, generating more than 410,000 lines of AI-assisted code, initiating more than 30,000 Copilot chats, and accelerating more than 100 AI use cases to improve care.

CareSource: Scaling compassionate service with cloud and AI

CareSource is applying AI to support operational scale while keeping a human touch. By modernizing platforms and automating processes that can slow service delivery, CareSource reduced documentation time by 75%, saved over USD125,000 on automation, and boosted developer productivity by up to 30%, helping their teams focus on the needs of members, providers, and communities.

Strengthening cyber resilience with AI

Cyber resilience is a transformation prerequisite. As care becomes more digital, AI must help defenders move at machine speed while maintaining trust and compliance. Frontier organizations use AI to triage, investigate, and report faster-reducing risk and freeing experts for the threats that matter most. In a sector where disruption can compromise patient safety, lagging security maturity can erase hard-won gains in digital transformation.

St. Luke's University Health Network: Saving nearly 200 hours per month with AI-powered security agents

As healthcare expands its digital footprint, cyber defense becomes inseparable from patient safety and trust. St. Luke's University Health Network is using Microsoft Security Copilot agents to accelerate phishing alert triage and to generate incident reports in minutes instead of hours. The organization reported saving nearly 200 hours per month, freeing security teams to focus on higher-value investigations and improving speed to response across its environment.

Act now to lead the future

If you're looking at these examples and wondering where to start, focus on a few moves that help you learn quickly and scale safely.

• Start with workflows, not technology: Identify the highest-friction moments (such as documentation, imaging backlogs, complex data synthesis, member service, and security triage) and design AI interventions that measurably reduce time, effort, and risk.
• Get your foundation right, early: Prioritize secure access, identity, and data governance so copilots and agents have the right context, without compromising privacy or compliance.
• Make it real, and make it stick: Operationalize responsible AI (like oversight, evaluation, and human-in-the-loop), measure quality and safety, and invest in change management so adoption scales beyond early enthusiasts.

Start your Frontier Transformation today

These organizations show what Frontier Transformation looks like in practice-embedding intelligence across clinical, operational, and administrative work to deliver faster insights, reduced burden, strengthen security, and create better experiences at scale. The competitive bar is moving quickly. Waiting to act can mean higher costs, slower throughput, and greater strain on already-stretched teams. With deep healthcare experience and a global customer base, Microsoft can help organizations scale AI responsibly from the first workflow to redesign to enterprise-wide adoption.