Statement of Changes in Beneficial Ownership (Form 4)

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Lux Venture Partners V, LLC 2. Issuer Name and Ticker or Trading Symbol Eikon Therapeutics, Inc. [EIKN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 920 BROADWAY, 11TH FLOOR, 3. Date of Earliest Transaction (Month/Day/Year) 02/04/2026 (Street) NEW YORK, NY 10010 4. If Amendment, Date Original Filed (Month/Day/Year) 6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/04/2026 P 138,888 A $18 138,888 I See Footnote(1) Common Stock 02/04/2026 P 138,888 A $18 138,888 I See Footnote(2) Common Stock 02/06/2026 C 2,387,705 A (3)(4) 2,387,705 I See Footnote(5) Common Stock 02/06/2026 C 1,151,540 A (4)(6)(7) 1,290,428 I See Footnote(1) Common Stock 02/06/2026 C 2,155,765 A (6)(7)(8)(9)(10) 2,294,653 I See Footnote(2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Preferred Stock	(3)	02/06/2026		C			10,000,000	(3)	(3)	Common Stock	1,340,878	(3)	0	I	See Footnote(5)
Series A-1 Preferred Stock	(4)	02/06/2026		C			7,807,026	(4)	(4)	Common Stock	1,046,827	(4)	0	I	See Footnote(5)
Series A-1 Preferred Stock	(4)	02/06/2026		C			2,502,252	(4)	(4)	Common Stock	335,521	(4)	0	I	See Footnote(1)
Series B Preferred Stock	(6)	02/06/2026		C			796,380	(6)	(6)	Common Stock	106,785	(6)	0	I	See Footnote(1)
Series B Preferred Stock	(6)	02/06/2026		C			530,920	(6)	(6)	Common Stock	71,190	(6)	0	I	See Footnote(2)
Series B-1 Preferred Stock	(7)	02/06/2026		C			5,289,322	(7)	(7)	Common Stock	709,234	(7)	0	I	See Footnote(1)
Series B-1 Preferred Stock	(7)	02/06/2026		C			3,526,215	(7)	(7)	Common Stock	472,822	(7)	0	I	See Footnote(2)
Series C Preferred Stock	(8)	02/06/2026		C			303,360	(8)	(8)	Common Stock	40,677	(8)	0	I	See Footnote(2)
Series C-1 Preferred Stock	(9)	02/06/2026		C			1,450,614	(9)	(9)	Common Stock	194,510	(9)	0	I	See Footnote(2)
Series D Preferred Stock	(10)	02/06/2026		C			10,266,152	(10)	(10)	Common Stock	1,376,566	(10)	0	I	See Footnote(2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Lux Venture Partners V, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY 10010		X
Wolfe Josh C/O EIKON THERAPEUTICS 230 HARRIET TUBMAN WAY MILLBRAE, CA 94030	X	X
Hebert Peter 920 BROADWAY, 11TH FLOOR NEW YORK, NY 10010		X
Lux Ventures V, L.P. 920 BROADWAY, 11TH FLOOR NEW YORK, NY 10010		X
Lux Co-Invest Opportunities II, L.P. 920 BROADWAY, 11TH FLOOR NEW YORK, NY 10010		X
Lux Total Opportunities, L.P. 920 BROADWAY, 11TH FLOOR NEW YORK, NY 10010		X

Signatures

/s/ Josh Wolfe		02/06/2026
**Signature of Reporting Person		Date
/s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date
Lux Ventures V, L.P., By: Lux Venture Partners V, LLC, its General Partner, By: Peter Hebert, Managing Member /s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date
Lux Venture Partners V, LLC, By: Peter Hebert, Managing Member /s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date
Lux Co-Invest Opportunities II, L.P., By: Lux Co-Invest Partners II, LLC, its General Partner, By: Peter Hebert, Managing Member /s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date
Lux Co-Invest Partners II, LLC, By: Peter Hebert, Managing Member /s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date
Lux Total Opportunities, L.P., By: Lux Total Opportunities Partners, LLC, its General Partner, By: Peter Hebert, Managing Member /s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date
Lux Total Opportunities Partners, LLC, By: Peter Hebert, Managing Member /s/ Peter Hebert		02/06/2026
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These shares are held by Lux Co-Invest Opportunities II, L.P. ("LCIO II"). Lux Co-Invest Partners II, LLC ("LCIP II") is the general partner of LCIO II and exercises voting and dispositive power over the shares noted herein held by LCIO II. Peter Hebert and Josh Wolfe, a member of the Issuer's board of directors (the "Individual Lux Managers"), are the individual managing members of LCIP II. The Individual Lux Managers, and as the sole managers of LCIP II, may be deemed to beneficially own the shares held by LCIO II. Each of LCIP II and the Individual Lux Managers disclaims beneficial ownership over these shares except to the extent of his pecuniary interest therein.
(2)	These shares are held by Lux Total Opportunities, L.P. ("LTO"). Lux Total Opportunities Partners, LLC ("LTOP") is the general partner of LTO and exercises voting and dispositive power over the shares noted herein held by LTO. The Individual Lux Managers are the individual managing members of LTOP. The Individual Lux Managers, as the sole managers of LTOP, may be deemed to beneficially own the shares held by LTO. Each of LTOP and the Individual Lux Managers disclaims beneficial ownership over these shares except to the extent of their pecuniary interest therein.
(3)	The Series A Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's initial public offering ("IPO") on a 1-for-7.4578 basis and had no expiration date.
(4)	The Series A-1 Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's IPO on a 1-for-7.4578 basis and had no expiration date.
(5)	These shares are held by Lux Ventures V, L.P. ("LVV"). Lux Venture Partners V, LLC ("LVPV") is the general partner of LVV and exercises voting and dispositive power over the shares noted herein held by LVV. The Individual Lux Managers are the individual managing members of LVPV. The Individual Lux Managers, as the sole managers of LVPV, may be deemed to beneficially own the shares held by LVV. Each of LVPV and the Individual Lux Managers disclaims beneficial ownership over these shares except to the extent of their pecuniary interest therein.
(6)	The Series B Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's IPO on a 1-for-7.4578 basis and had no expiration date.
(7)	The Series B-1 Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's IPO on a 1-for-7.4578 basis and had no expiration date.
(8)	The Series C Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's IPO on a 1-for-7.4578 basis and had no expiration date.
(9)	The Series C-1 Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's IPO on a 1-for-7.4578 basis and had no expiration date.
(10)	The Series D Preferred Stock converted into Common Stock immediately prior to the closing of the Issuer's IPO on a 1-for-7.4578 basis and had no expiration date.

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