Elanco Australia Receives APVMA Approval for Advocate™ Ultra Chew: The Broadest Spectrum Parasite Protection* for Dogs in Australia

Sydney, Australia - February 20, 2026 - Elanco Animal Health Incorporated today announced that the Australian Pesticides and Veterinary Medicines Authority (APVMA) has registered Advocate™ Ultra Chew (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets). Launching in April 2026, this approval introduces the broadest spectrum parasite protection* available for Australian dogs in a single monthly dose.

Known in the U.S. as Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets), the Australian approval marks the first geographic expansion for the product. This innovation will launch in Australia under the trusted Advocate™ brand name. Advocate Ultra Chew combines four well-established active ingredients in a tasty chew, delivering the broadest protection* of any all-in-one product against fleas, ticks (including paralysis ticks), heartworm and intestinal worms, including tapeworms. For Australian dog owners, the Paralysis Tick (Ixodes holocyclus), which occurs mainly along the eastern coast of Australia, is a primary concern due to the potentially fatal toxicosis it causes.

The broadest parasite protection in one single dose*

Importantly, Advocate Ultra Chew is the only all-in-one product that kills tapeworms, including those that are zoonotic and pose a serious risk to human health, like hydatid tapeworm (Echinococcus granulosus).

"Parasites are not just a nuisance; they pose health risks to dogs and their families. In a time where the bond between humans and pets is closer than ever, the risk of zoonotic diseases cannot be ignored," said Dr. Liisa Ahlstrom, Technical Services Veterinarian, Pet Health Parasiticides at Elanco Australia. "Advocate Ultra Chew offers dog owners convenience and peace of mind by providing the broadest spectrum protection* available in a single monthly tasty chew. By adding tapeworm, we are elevating the zoonotic coverage and offering a new standard of care to protect the health of dogs and their families."

A New Frontier for a Trusted Brand

"We are incredibly proud to bring this global innovation to Australian veterinarians and pet owners under the Advocate name - a brand that has stood for trust and comprehensive protection in this market for years," said Lance Williams, Vice President, Pacific Rim at Elanco. "With Advocate Ultra Chew, we are delivering the same breakthrough 4-in-1 product that is revolutionizing the U.S. market, tailored to meet the challenging demands of the Australian environment."

Safety and Availability

Advocate Ultra Chew has been shown to be safe for use in dogs and puppies from 8 weeks of age and weighing 2 kg or greater. Safety has been demonstrated in heartworm-positive dogs and across various breeds, including avermectin-sensitive Collies.

Advocate Ultra Chew will be available from April 2026.

For more information about Advocate™ Ultra Chew in Australia, visit https://www.elanco.com/en-au. Always read and follow label directions.

*Of all canine endectocides, based on number of parasite species controlled.

CREDELIO QUATTRO IMPORTANT SAFETY INFORMATION

Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, incoordination, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult heartworms. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For complete safety information, please see the Credelio Quattro product label or ask your veterinarian.

Credelio Quattro, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Other company and product names are trademarks of their respective owners.

© 2026 Elanco or its affiliates

ABOUT ELANCO​

Elanco Animal Health Incorporated is a global leader in animal health dedicated to innovating and delivering products and services to prevent and treat disease in farm animals and pets, creating value for farmers, pet owners, veterinarians, stakeholders and society as a whole. With 70 years of animal health heritage, we are committed to breaking boundaries and going beyond to help our customers improve the health of animals in their care, while also making a meaningful impact on our local and global communities. At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose - all to Go Beyond for Animals, Customers, Society and Our People. Learn more at https://www.elanco.com.