Amendments to Bylaws (Form 8-K)

Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year.

On October 26, 2026, Lycia Therapeutics, Inc. (the "Company") filed its Amended and Restated Certificate of Incorporation (the "Charter") with the Secretary of State of the State of Delaware and its Amended and Restated Bylaws (the "Bylaws") became effective in connection with the closing of the initial public offering (the "Offering") of shares of the Company's common stock, par value $0.0001 per share. As described in the final prospectus, dated October 22, 2026 (the "Prospectus"), relating to the Registration Statement on Form S-1 (File No. 333-299300, as amended), filed with the Securities and Exchange Commission pursuant to Rule 424(b) under the Securities Act of 1933, as amended, the Company's board of directors and stockholders previously approved the amendment and restatement of these documents to be effective immediately prior to the closing of the Company's Offering. A description of certain provisions of the Charter and the Bylaws is set forth in the section titled "Description of Capital Stock" in the Prospectus. The foregoing description of the Charter and the Bylaws is qualified in its entirety by reference to (1) the Charter filed as Exhibit 3.1 hereto and (2) the Bylaws filed as Exhibit 3.2 hereto, each of which is incorporated herein by reference.