Health Advisory: Increase in Diphenhydramine Abuse Among Teens Reported to U.S. Poison Centers

June 12, 2026-America's Poison Centers^® is reporting a concerning rise in cases involving diphenhydramine (commonly found in over-the-counter allergy and sleep medications, e.g., Benadryl^® and Zzzquil^®) among teens ages 13-19.

From 2024 to 2025, total exposure cases to any substance among teens 13-19 increased by 5.1%. During that same time, cases involving diphenhydramine increased much faster, from 10,068 cases in 2024 to 13,284 cases in 2025, a 31.9% increase. Early 2026 data suggest this trend is continuing. In the first five months of 2026, there were 6,179 diphenhydramine-only cases among teens, more than double compared to the same time in 2025, and numbers are still rising.

The increase in exposure appears to be driven by teens using diphenhydramine on purpose to get high rather than accidental medication errors. In 2026, 13.2% of teen diphenhydramine-only cases are linked to intentional abuse, up from 7.3% in 2020.

Diphenhydramine can be dangerous when taken in large amounts or used improperly. High doses can affect the brain and heart and may lead to serious or life-threatening effects.

Symptoms of diphenhydramine poisoning include:

• Drowsiness or extreme sleepiness
• Agitation
• Fast heart rate
• Nausea or vomiting
• Hallucinations
• Seizures
• Dangerous heart rhythm problems
• Loss of consciousness

America's Poison Centers advises the public to:

• Store all medications, including over-the-counter products, up high, out of sight and reach of children and teens.
• Talk with teens about the risks of misusing medications, including serious health effects and poisoning.
• Follow label directions carefully and never take more than the recommended dose.
• Be aware of social media trends or challenges that may encourage unsafe use of medications.
• Contact your local Poison Control Center right away if you suspect misuse or have questions: call 1-800-222-1222 or visit PoisonHelp.org.

Poison Control Centers are available 24/7 for fast, free, confidential, expert medical advice for poison exposures and medication safety.